Targeted Drug Delivery (표적 가능한 약물 전달 연구)

The biological barriers such as cell membrane, blood brain barrier, mucosa, etc are the main hurdles that interfere with the intracellular transportation of biomolecules and small molecular drugs. It is reported that more than 90% of clinical drug candidates fail in development due to their poor cellular uptake and tissue penetration.

We intend to synthesize and develop a novel drug delivery vector that can not only deliver the drug into cells but also target the drug to a specific cell or subcellular organelle. For this aim, we have synthesized molecular transporters having multiple guanidines that can internalize efficiently into cells, and heterobifunctional linkers for efficient binding between the drug carrier and the payload.