Publications
Embedded Files
Book chapters
BC6. Application of Copper Chelators in Cancer Therapeutics
Luís M. T. Frija
In Science for Sustainability, Edited by A. J. L. Pombeiro et. al. (25 pages), World Scientific, 2025
Multivolume book (5 volumes, 44 chapters) celebrating the 20th anniversary of the European Academy of Sciences (EurASc)
Selected as “A World Science Reference”.
(under production)
BC5. Synthesis of non-symmetrical 1,2,4,5-tetraoxanes: Past and current routes
Patrícia S. M. Amado, Luís M. T. Frija, Paul M. O’Neill and Maria L. S. Cristiano*
In Synthesis and Applications in Chemistry and Materials, Edited by A. J. L. Pombeiro. pp. 113-159, World Scientific, 2024
https://doi.org/10.1142/9789811283215_0016
BC4. 1,2-Benzisothiazole 1,1-Dioxide (Saccharinate)-Based Compounds: Synthesis, Reactivity and Applications
Luís M. T. Frija*, André L. Fernandes, Bruno Guerreiro and M. Lurdes S. Cristiano
In More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, Vol. 3, ch. 19, Edited by Ana M. Phillips. United Kingdom, Wiley, 2022
https://doi.org/10.1002/9781119757153.ch19
BC3. Catalytic Alkane Amidation and Related Reactions
Dmytro S. Nesterov, Luís M. T. Frija, Armando J. L. Pombeiro and Maximilian N. Kopylovich
In Alkane Functionalization, 1st Edition, Chapter 19, 427-448. Eds. A. J. L. Pombeiro and M. F. C. Guedes da Silva, John Wiley & Sons Ltd., 2019
https://doi.org/10.1002/9781119379256.ch19
BC2. Isolation and manipulation of a diterpene from the Portuguese Flora
Carlos A. M. Afonso* and Luís M. T. Frija*
In 100 Organic Chemistry Experiments, IST Press, 25-28, 2011 (ISBN: 978-989-8481-09-2)
istpress.tecnico.ulisboa.pt/produto/100-experiencias-de-quimica-organica/
BC1. Photochemistry of Tetrazole Derivatives in Cryogenic Rare Gas Matrices
A. Gómez-Zavaglia, I. D. Reva, Luís M. T. Frija, M. L. S. Cristiano and R. Fausto*
In Photochemistry Research Progress, Chapter 9, 295-324. Editors: Alejandro Sánchez and Sergio J. Gutierrez. Nova Science Publishers, Inc., NY, USA. 2008
https://www.novapublishers.com/catalog/product_info.php?products_id=7189
Journal articles (peer-reviewed)
39. Understanding synergistic bridging of MOFs in mechanical energy harvesting through triboelectric generation
Brij Mohan, Bakhtiyar Najafov, Hongli Wen, Luís M. T. Frija, Alexander A. Solovev, Gurjaspreet Singh,* Armando J. L. Pombeiro, Rakesh K. Gupta,* and Wei Sun*; Journal of Energy Chemistry 2026, 113, 1030-1047
https://doi.org/10.1016/j.jechem.2025.10.004
38. Unanticipated Reactivity Towards Nucleophilic Attack in the Synthesis of Saccharyl-1,3,4-Thiadiazolyl Conjugates: Structure and Mechanistic Insights
Bruno E. C. Guerreiro, Daniel Carvalho, Jaime A. S. Coelho, José A. Paixão, Luís M. T. Frija* and Maria L. S. Cristiano*; J. Org. Chem. 2025 (Accepted)
37. Synthesis and structure of novel pyrimidine-thioethers: structural effects on reactivity along with an unpredicted dimethylamination reaction
Inês C. C. Costa, Luís M. T. Frija, André F. Augusto, José A. Paixão* and Maria L. S. Cristiano*; ChemPhysChem 2025, 26, e202500308
https://doi.org/10.1002/cphc.202500308 HOT PAPER
36. A convenient TBHP/Cu(NO3)2∙2.5H2O-mediated oxidation of secundary and benzyl alcohols under microwave irradiation
Luís M. T. Frija*; J. Chem. Sci. 2025, 137, 60
doi.org/10.1007/s12039-025-02370-1
35. Hybrid azole-based conjugates as upcoming anticancer and antimicrobial agents
Luís M. T. Frija*, Bruno E. C. Guerreiro, Inês C. C. Costa, Vera M. S. Isca, Lucília Saraiva, Beatriz G. Neves, Mariana Magalhães, Célia Cabral, Maria L. S. Cristiano and Patrícia Rijo*; Exploration of Drug Science 2023, 1, 420-434
https://doi.org/10.37349/eds.2023.00028
34. In an era where the Chemistry has to be green! Red Alert!
Luís M. T. Frija*; Insights in Chemistry & Biochemistry 2023, 2(4), 1
http://dx.doi.org/10.33552/ICBC.2023.02.000542
33. Synthesis of non-symmetrical dispiro 1,2,4,5-tetraoxanes and 1,2,4-trioxanes catalyzed by Silica Sulfuric Acid
Patrícia S. M. Amado, Luís M. T. Frija, Jaime A. S. Coelho, Paul M. O’Neill* and Maria L. S. Cristiano*; J. Org. Chem. 2021, 86, 10608-10620
https://doi.org/10.1021/acs.joc.1c01258
32. Solvent-free Oxidation of Benzyl Alcohols Catalysed by a Tetrazole-saccharinate Zn(II) Complex under Microwave Radiation: the role of the Ligand and the Reaction Mechanism
Luís M. T. Frija*, André L. Fernandes, M. Lurdes S. Cristiano and Armando J. L. Pombeiro; J. Mol. Struct. 2020, 1222, 128831
https://doi.org/10.1016/j.molstruc.2020.128831
31. Well-defined Nickel(II) Tetrazole-saccharinate Complex as Homogeneous Catalyst on the Reduction of Aldehydes: Scope and Reaction Mechanism
Luís M. T. Frija*, Bruno G. M. Rocha, Maxim L. Kuznetsov, Lília I. L. Cabral, M. Lurdes S. Cristiano and Armando J. L. Pombeiro; Pure & Applied Chemistry 2020, 92, 151-166
https://doi.org/10.1515/pac-2019-0220
30. In vitro Assessment of Antimicrobial, Antioxidant and Cytotoxic Properties of Saccharin‑Tetrazolyl and ‑Thiadiazolyl Derivatives; The Simple Dependence of the pH Value on Antimicrobial Activity
Luís M. T. Frija*, Epole Ntungwe, Przemysław Sitarek, Joana M. Andrade, Monika Toma, Tomasz Śliwiński, Lília Cabral, M. Lurdes S. Cristiano, Patrícia Rijo* and Armando J. L. Pombeiro; Pharmaceuticals 2019, 12, 167
http://dx.doi.org/10.3390/ph12040167
29. Synthesis, Structure and Cytotoxicity of a Novel Sulphanyl-Bridged Thiadiazolyl-Saccharinate Conjugate: The Relevance of S...N Interaction
L. Cabral, E. Brás, M. Henriques, C. Marques, Luís M. T. Frija, L. Barreira, José A. Paixão, R. Fausto*, Maria L. S. Cristiano*; Chem. Eur. J. 2018, 24, 3251-3262
https://doi.org/10.1002/chem.201705319 HOT PAPER
28. Organocatalyzed oxidation of benzyl alcohols by a tetrazole-amino-saccharin: A combined experimental and theoretical (DFT) study
Luís M. T. Frija*, Maxim L. Kuznetsov, Bruno G.M. Rocha, Lília Cabral, M. Lurdes S. Cristiano, Maximilian N. Kopylovich, Armando J. L. Pombeiro; Molecular Catalysis 2017, 442, 57-65
http://dx.doi.org/10.1016/j.mcat.2017.09.003
27. Proteomic insights on the metabolism of Penicillium janczewskii during the biotransformation of the plant terpenoid labdanolic acid
Isabel Martins, Adélia Varela, Luís M. T. Frija, Mónica A. S. Estevão, Sébastien Planchon, Jenny Renaut, Carlos A. M. Afonso and Cristina S. Pereira*; Front. Bioeng. Biotechnol. 2017, 5:45, 1-12
https://doi.org/10.3389/fbioe.2017.00045
26. Building 1,2,4-Thiadiazole: Ten Years of Progress
Luís M. T. Frija*, Armando J. L. Pombeiro and Maximilian N. Kopylovich*; Eur. J. Org. Chem. 2017, 2670-2682
https://doi.org/10.1002/ejoc.201601642
25. Copper(II) and cobalt(II) tetrazole-saccharinate complexes as effective catalysts for oxidation of secondary alcohols
Luís M. T. Frija*, E. C. B. A. Alegria, M. Sutradhar, M. Lurdes S. Cristiano, A. Ismael, M. N. Kopylovich and A. J. L. Pombeiro*; J. Mol. Catal. A: Chem. 2016, 425, 283-290
http://dx.doi.org/10.1016/j.molcata.2016.10.023
24. Coordination Chemistry of Thiazoles, Isothiazoles and Thiadiazoles
Luís M. T. Frija*, Armando J. L. Pombeiro and Maximilian N. Kopylovich*; Coord. Chem. Rev. 2016, 308, 32-55
https://doi.org/10.1016/j.ccr.2015.10.003
23. Supported Acid-catalyzed Flash Vacuum Thermolysis on the Valorisation of Labdanum Resin
Luís M. T. Frija* and Carlos A. M. Afonso*; Biomass & Bioenergy 2014, 71, 363-369
https://doi.org/10.1016/j.biombioe.2014.09.020
22. Isolation, analytical quantification and seasonal variation of labdanolic acid from the Portuguese-grown Cistus ladaniferus
André N. C. Martins, Svilen P. Simeonov, Luis M. T. Frija*, Raquel Viveiros, Anita Lourenço, Mara S. da Silva, Teresa Casimiro and Carlos A. M. Afonso*; Ind. Crop. Prod. 2014, 60, 226-232
https://doi.org/10.1016/j.indcrop.2014.06.012
21. Genesis of rare molecules using light-induced reactions of matrix-isolated tetrazoles
Luís M. T. Frija*, M. L. S. Cristiano, A. Gómez-Zavaglia, I. D. Reva and R. Fausto; J. Photochem. Photobiol. C: Photochem Rev. 2014, 18, 71-90
https://doi.org/10.1016/j.jphotochemrev.2013.09.001
20. Short Synthesis of the Natural Product 3beta-Hydroxy-labd-8 (17)-en-15-oic Acid via Microbial Transformation of Labdanolic Acid
Luís M. T. Frija*, Helga Garcia, Cátia Rodrigues, Isabel Martins, Nuno R. Candeias, Vânia André, M. Teresa Duarte, Cristina Silva Pereira* and Carlos A. M. Afonso*; Phytochem. Lett. 2013, 6, 165-169
https://doi.org/10.1016/j.phytol.2012.12.005
19. Amberlyst®-15: a Reusable Heterogeneous Catalyst for the Dehydration of Tertiary Alcohols
Luís M. T. Frija* and Carlos A. M. Afonso*; Tetrahedron 2012, 68, 7414-7421
https://doi.org/10.1016/j.tet.2012.06.083
18. Sigmatropic Rearrangements in 5-Allyloxytetrazoles
Luís M. T. Frija, I. Reva, D. V. Coelho, A. Ismael, R. Fausto and M. L. S. Cristiano*; Org. Biomol. Chem. 2011, 9, 6040-6054
https://doi.org/10.1039/C1OB05460K
17. Isolation, Chemical and Bio-transformation Routes of Labdane-type Diterpenes
Luís M. T. Frija*, Raquel F. M. Frade* and Carlos A. M. Afonso*, Chemical Reviews 2011, 111, 4418-4452
https://doi.org/10.1021/cr100258k
16. Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis
Luís M. T. Frija, Amin Ismael and M. L. S. Cristiano*; Molecules 2010, 15, 3757-3774
https://doi.org/10.3390/molecules15053757
15. Synthesis and Structure of Novel Benzisothiazole-tetrazolyl Derivatives for Potential Application as Nitrogen Ligands
Luís M. T. Frija, R. Fausto, Rui M. S. Loureiro and M. L. S. Cristiano*; J. Mol. Catal. A: Chem. 2009, 305, 142-146
https://doi.org/10.1016/j.molcata.2008.12.007
14. Photochemistry of Tetrazole Derivatives in Cryogenic Rare Gas Matrices
A. Gómez-Zavaglia, I. D. Reva, Luís M. T. Frija, M. L. S. Cristiano and R. Fausto*; Chemical Physics Research Journal 2009, 1(4), 221-250
http://www.novapublishers.org/catalog/product_info.php?products_id=7195
13. Photochemistry of 5-Allyloxy-tetrazoles: Steady-state and Laser Flash-Photolysis Study
Luís M. T. Frija, I. V. Khmelinskii, I. D. Reva, C. Serpa, R. Fausto and M. L. S. Cristiano*; Org. Biomol. Chem. 2008, 6, 1046-1055
https://doi.org/10.1039/B718104C
12. UV-Induced Photochemistry of Matrix-Isolated 1-Phenyl-4-Allyl-Tetrazolone
Luís M. T. Frija, I. D. Reva, A. Gómez-Zavaglia, M. L. S. Cristiano and R. Fausto*; Photochem. Photobiol. Sci. 2007, 6, 1170-1176
https://doi.org/10.1039/B703961A
11. Photochemistry and Vibrational Spectra of Matrix-Isolated 5-Ethoxy-1-Phenyl-1H-Tetrazole
Luís M. T. Frija, I. D. Reva, A. Gómez-Zavaglia, M. L. S. Cristiano and R. Fausto; J. Phys. Chem. A. 2007, 111, 2879-2888
https://doi.org/10.1021/jp068556h
10. Photochemical Ring-opening and Intramolecular Hydrogen Shift Reactions in Sulfur Analogues of α-Pyrone
S. Breda, I. Reva, L. Lapinski, M. L. Cristiano, L. Frija and R. Fausto*; J. Phys. Chem. A. 2006, 110, 6415-6425
https://doi.org/10.1021/jp061139k
9. Infrared Spectrum and UV-Induced Photochemistry of 5-Methoxy-1-Phenyl-Tetrazole Isolated in Solid Argon
A. Gómez-Zavaglia, I. D. Reva, L. Frija, M. L. Cristiano and R. Fausto*; J. Photochem. Photobiol. A: Chem. 2006, 180, 175-183
https://doi.org/10.1016/j.jphotochem.2005.10.012
8. Molecular Structure, Vibrational Spectra and Photochemistry of 5-Mercapto-1-Methyltetrazole in Solid Argon
A. Gómez-Zavaglia, I. D. Reva, L. Frija, M. L. Cristiano and R. Fausto*; J. Mol. Struct. 2006, 786, 182-192
https://doi.org/10.1016/j.molstruc.2005.08.019
7. Mechanistic Investigations into the Photochemistry of 4-Allyl-tetrazolones in Solution; A New Approach to the Synthesis of 3,4-Dihydro-pyrimidinones
Luís M. T. Frija, Igor V. Khmelinskii and M. Lurdes S. Cristiano*; J. Org. Chem. 2006, 71, 3583-3591
https://doi.org/10.1021/jo060164j
6. Photochemistry of 1-Phenyl-Tetrazolone Isolated in Solid Argon
A. Gómez-Zavaglia, I. D. Reva, L. Frija, M. L. Cristiano and R. Fausto*; J. Photochem. Photobiol. A: Chem. 2006, 179, 243-255
https://doi.org/10.1016/j.jphotochem.2005.08.021
5. Palladium-catalysed Reduction of Heteroaromatic Naphthyl Ethers: Structural Effects on Reactivity
Luís M. T. Frija, M. Lurdes S. Cristiano*, Emanuel M. O. Guimarães, Nélson C. Martins and J. F. Bickley; J. Mol. Catal. A: Chem. 2005, 242, 241-250
https://doi.org/10.1016/j.molcata.2005.08.022
4. Novel Efficient Synthesis of 3,4-Dihydro-6-substituted-3-phenylpyrimidin-2(1H)-ones
Luís M. T. Frija, Igor V. Khmelinskii and M. Lurdes S. Cristiano*; Tetrahedron Lett. 2005, 46, 6757-6760
https://doi.org/10.1016/j.tetlet.2005.07.101
3. Molecular Structure, Vibrational Spectra and Photochemistry of 2-Methyl-2H-Tetrazol-5-Amine in Solid Argon
A. Gómez-Zavaglia, I. D. Reva, L. Frija, M. L. Cristiano and R. Fausto*; J. Phys. Chem. A. 2005, 109, 7967-7976
https://doi.org/10.1021/jp0517706
2. Heteroaromatic Benzyl Ethers as Intermediates for Heterogeneous Catalytic Transfer Hydrogenolysis of Benzyl Alcohols
Nuna C. P. Araújo, Amadeu F. Brigas*, M. Lurdes S. Cristiano*, Luís M. T. Frija, Emanuel M. O. Guimarães and Rui M. S. Loureiro; J. Mol. Catal. A: Chem. 2004, 215, 113-120
https://doi.org/10.1016/j.molcata.2003.12.033
1. Vibrational Spectra and Structure of 1-Phenyltetrazole and 5-Chloro-1-Phenyltetrazole. A Combined Study by Low Temperature Matrix Isolation and Solid State FTIR Spectroscopy and DFT Calculations
Susana C. S. Bugalho, Leszek Lapinski, M. Lurdes S. Cristiano, Luís M. T. Frija and Rui Fausto*; Vib. Spectrosc. 2002, 30, 213-225
https://doi.org/10.1016/S0924-2031(02)00028-0
Theses
T2. Investigation of Structural Effects on the Reactivity of Heterocyclic Bioactive Compounds
Luís Miguel Teodoro Frija, Ph.D. Thesis, Chemistry – Organic Chemistry, University of Algarve, 2008
http://hdl.handle.net/10400.1/856
T1. Design and Synthesis of Compounds with Potential Biological Activity
Luís Miguel Teodoro Frija, Scientific Final Project Thesis, Degree in Chemistry (Tese de projecto final da Licenciatura em Química), University of Algarve, 2001
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