Teaching

From 2016/17 to 2024/25 Bio-, Photo-, Eletro-Catalysis (Photodynamic catalysis lectures); PhD Program in Chemistry (CATSUS), University  of Lisbon, (IST)

2016-2017 Laboratórios de Especialização I (Projecto); Mestrado em Química; University of Lisbon (IST)

2015-2016 Bio-, Photo-, Eletro-Catalysis (Photodynamic catalysis, lectures); PhD Program in Chemistry (CATSUS), University of Lisbon, (IST)          

2013-2014 Organic Chemistry II (Lab. component); Master Degree in Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon (FF-UL)

2012-2013 Physical-Chemistry (Lab. component); Master Degree in Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon (FF-UL)

2011-2012 Physical-Chemistry (Lab. component); Master Degree in Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon (FF-UL)

2002-2003 Organic Chemistry II (Lab. component); Degree in Biotechnologic Engineering, Faculty of Engineering of Natural Resources (FERN), University of Algarve (UAlg) 

Student's and Researchers Supervision

Co-supervision of Final Degree project: 5 students (Degree in Chemistry)

Scientific Traineeships: 3 students (Master Degree in Pharmaceutical Sciences, Project II, FFUL)

Co-supervision of Master Dissertation: 2 students (Master Degree in Chemistry; Organic chemistry)

Co-supervision of PhD Thesis: 2 students (PhD in Chemistry)

Referee Activity to International Publications

• Journal of Molecular Structure / Chemical Physics / Tetrahedron Letters / Arabian Journal of Chemistry / Molecular Catalysis / Green Synthesis and Catalysis (Elsevier)

• Molecules / Pharmaceuticals / Antibiotics / International Journal of Molecular Sciences / Biology and Life Sciences Forum (MDPI) 

• European Journal of Organic Chemistry / Advanced Synthesis & Catalysis / ChemCatChem / Zeitschrift fur Anorganische und Allgemeine Chemie / ChemistrySelect (Wiley)

• Pure and Applied Chemistry (IUPAC)

• The Journal of Physical Chemistry (ACS)

• Polycyclic Aromatic Compounds (Taylor & Francis Group)

• Scientific Reports / Reaction Kinetics, Mechanisms and Catalysis / Chemistry Central Journal / BMC Chemistry (Springer Nature) 

Conferences and Scientific Meetings

Oral Communications

• Structure and Reactivity of Heteroaromatic Allyl Tetrazolyl and Isothiazolyl Ethers
  M. Lurdes S. Cristiano, Luís M. T. Frija, Rui M. S. Loureiro and Amadeu F. Brigas; XVIth International Conference on Physical Organic Chemistry (ICPOC 16), San Diego, CA, USA, 2002, LC9.

• Mechanistic Investigation into the Thermal Decomposition of Urethanes
  M. Lurdes S. Cristiano, Sharon Dowd, John Davies, Luís M. T. Frija, Robert A. W. Johnstone and Rui M. S. Loureiro; ESOR IX, European Symposium on Organic Reactivity, Oslo, July, 2003, OR17.

• Photochemistry of 5-Allyl-tetrazoles and 4-Allyl-tetrazolones in Solution
  M. Lurdes S. Cristiano, Luís M. T. Frija and Igor V. Khmelinskii; Twelfth FECHEM conference on Heterocycles in Bio-organic Chemistry, Siena, July, 2004.

• Photochemistry of 4-Allyl-tetrazolones in Solution
  Lurdes S. Cristiano, Luís M. T. Frija and Igor V. Khmelinskii;  ESOR X, European Symposium on Organic Reactivity, Roma, July, 2005.

• Photochemistry of Allylic Derivatives of Tetrazole and Benzisothiazole
  M. Lurdes S. Cristiano, Luís M. T. Frija, Daniela V. Coelho, Igor V. Khmelinskii and Rui Fausto; Transmediterranean Colloquium on Heterocyclic Chemistry, Aveiro, June, 2006.

• Catalytic Reduction of Heteroaromatic Naphthyl Ethers: Structural Effects on Reactivity
  M. Lurdes S. Cristiano, Nuna Araújo, Paula Pena and Luís M. T. Frija; XVIIIth International Conference on Physical Organic Chemistry (ICPOC 18), Warsaw, Poland, 2006.

• Structure and Photochemistry of Tetrazoles
  Luís M. T. Frija, M. Lurdes S. Cristiano and Rui Fausto; 8º Encontro Nacional de Química-Física da SPQ, Luso-Coimbra, June, 2007.

• Isomerizations in Heteroaromatic Allyl Ethers: Selectivity and Mechanisms
  Lurdes S. Cristiano, A. Ismael, Luís M. T. Frija, R. Fausto and I. Reva; XXth International Conference on Physical Organic Chemistry (ICPOC 20), Busan, South Korea, August, 22-28, 2010 (O18).

• Synthetic and bio-transformations of portuguese natural resources derived from Cistus ladaniferus
  Luís M. T. Frija, Carlos A. M. Afonso, Cátia Rodrigues, Helga Garcia, Isabel Martins and Cristina Silva Pereira; XVI Encontro Luso-Galego de Química, Aveiro, November 10-12, 2010.

• Chemistry of diterpenes… an intense challenge!
  Luís M. T. Frija; University of Algarve, DQF, Doctoral program in Chemistry: Seminars, Faro, June 23, 2014. (Invited)

• Organocatalyzed Oxidation of Benzyl Alcohols by a Tetrazole-Amino-Saccharinate: A Combined Experimental and Theoretical (DFT) Study
  Bruno G. M. Rocha, Luís M. T. Frija, Maximilian N. Kopylovich, Maxim L. Kuznetsov, Lília Cabral, M. Lurdes S. Cristiano, Armando J. L. Pombeiro; International Symposium on Synthesis and Catalysis (ISySyCat), Évora, September 5-8, 2017.

• Synthesis of novel tetrazolyl-benzisothiazole derivatives and their application as catalysts on the oxidation of alcohols
  Luís M. T. Frija, B. G. M. Rocha, L. Cabral, M. L. S. Cristiano, M. N. Kopylovich, A. J. L. Pombeiro; 3.º Encontro do Colégio de Química, ULisboa: Chemistry at ULisboa & 2018 Summer School, Lisboa, June 27-29, 2018.

• Broad-spectrum Azole-based Molecules: From Strong Ligands in Coordination Chemistry to Organocatalysts
  Luís M. T. Frija, B. G. M. Rocha, L. Cabral, M. L. S. Cristiano, M. N. Kopylovich, A. J. L. Pombeiro; 24th IUPAC International Conference on Physical Organic Chemistry (ICPOC24), Faro, July 1-6, 2018.

• Antimicrobial, antioxidant and cytotoxic activities of saccharin-tetrazolyl and -thiadiazolyl derivatives
  Luís M. T. Frija, Epole Ntungwe, Przemysław Sitarek, Joana M. Andrade, Monika Toma, Tomasz Śliwiński, Lília Cabral, M. Lurdes S. Cristiano, Patrícia Rijo, Armando J. L. Pombeiro; Chemistry: Shaping the Future, 4º Encontro do Colégio de Química, ULisboa, Lisboa, July 16-19, 2019.

• Nickel(II) tetrazole-saccharinate complex as homogeneous catalyst on the reduction of aldehydes: scope and reaction mechanism
  Bruno G. M. Rocha, Luís M. T. Frija, Maxim L. Kuznetsov, Lília Cabral, M. Lurdes S. Cristiano, Armando J. L. Pombeiro; 1st International Conference on Noncovalent Interactions (ICNI-2019), Lisboa, September 2-6, 2019.

• Hybrid Azoles: Mutual Effectiveness as Catalysts and Probes on Cancer Therapy
  Luís M. T. Frija, ChemForum, 2024 Autumn Edition, IST-UL, Lisboa, October 16, 2024. (Invited)

Panel Communications (poster)

• Vibrational Spectra and Structure of 1-Phenyltetrazole and 5-Chloro-1-Phenyltetrazole; Susana C. S. Bugalho, Leszek Lapinski, M. Lurdes S. Cristiano, Luís M. T. Frija and Rui Fausto; XXVI European Congress on Molecular Spectroscopy (EUCMOS XXVI), Villeneuve d’Ascq, 2002.

• Estrutura e Reactividade de Éteres Alílicos Heteroaromáticos: Isomerização Térmica do 3-(Ciclohex-2-eniloxi)-1,2-benzisotiazol 1,1-dióxido e 5-(Ciclohex-2-eniloxi)-1-fenil-1H-tetrazol; Luís M. T. Frija e Amadeu F. Brigas; 5º Encontro Nacional de Química Orgânica & 1º Simpósio Luso-Japonês, SPQ, Aveiro, 2003.

• Mechanistic Investigation of Sigmatropic Isomerizations in Allyl Isothiazolyl Ethers; Luís M. T. Frija, M. Lurdes S. Cristiano, Daniela Coelho and Rui M. S. Loureiro; 6º Encontro Nacional de Química Física, SPQ, Lisboa, 2003.

• Theoretical Approach to the Comprehension of Intermolecular Radical Addition to 2H-Azirines; Luís M. T. Frija, Emanuel Guimarães and Américo Lemos; XIX Encontro da Sociedade Portuguesa de Química, Coimbra, 2003.

• Structure and Reactivity of Isothiazolyl Ethers; Luís M. T. Frija, M. Lurdes S. Cristiano and Daniela Coelho; XIX Encontro da Sociedade Portuguesa de Química, Coimbra, 2003.

• Photochemistry in Rare Gas Matrix Isolated Derivatives of Tetrazole; A. Gómez-Zavaglia, I. D. Reva, Luís M. T. Frija, M. Lurdes S. Cristiano and R. Fausto; XX IUPAC SYMPOSIUM IN PHOTOCHEMISTRY, Granada, July, 2004.

• Mechanistic Studies on the Photorearrangement of o-Nitrobenzyl Compounds; Luís M. T. Frija, M. Lurdes S. Cristiano, José P. Da Silva and Luís F. Vieira Ferreira; XX IUPAC SYMPOSIUM IN PHOTOCHEMISTRY, Granada, July, 2004.

• Investigations Into the Mechanism of Thermolysis of Lithographically Useful Urethanes; M. Lurdes S. Cristiano, Moya McCarron, John Davies, Luís M. T. Frija, Robert A. W. Johnstone and Rui M. S. Loureiro; RSC - Reaction Mechanisms VII, University College Dublin, July, 2004.

• Molecular Structure, Vibrational Spectra and Photochemistry of 1-Phenyl-4H-Tetrazolone Isolated in Solid Argon; Gómez-Zavaglia, A., Reva, I. D., Frija, L., Cristiano, M. L. and Fausto R.; 7º Encontro Nacional de Química-Física, SPQ, Porto, May 5-7, 2005. (Best Poster Award)

• Síntese e Estudo da Reactividade de Carbamatos com Aplicação em Processos Litográficos; Luís M. T. Frija, Rui M. S. Loureiro, Moya McCarron, Robert A. W. Johnstone, M. Lurdes S. Cristiano; Encontro Química ao Sul – Interacção Universidade/Empresas, Faro, May, 2005.

• Síntese e Reactividade de Compostos Heterocíclicos com Potencial Actividade Biológica; Luís M. T. Frija, M. Lurdes S. Cristiano, Edite M. G. Veríssimo, Daniela Coelho, Emanuel Morgado, Amin Ismael; Encontro Química ao Sul – Interacção Universidade/Empresas, Faro, May, 2005.

• Vibrational Spectra and Photochemistry of 5-Mercapto-1-methyltetrazole in Solid Argon; A. Gómez-Zavaglia, I. D. Reva, L. Frija, M. L. Cristiano and R. Fausto; Molecular Structure, Matrix 2005- The Physics and Chemistry of Matrix Isolated Species, Funchal, July 24-29, 2005.

• Vibrational Spectra and Photochemistry of 2-Methyl-2H-tetrazol-5-amine in Solid Argon; R. Fausto, I. D. Reva, L. Frija, M. L. Cristiano and A. Gómez-Zavaglia; Molecular Structure, Matrix 2005-The Physics and Chemistry of Matrix Isolated Species, Funchal, July 24-29, 2005.

• Kinetics and Mechanism of Thermolysis of Carbamates; Luís M. T. Frija, Rui M. S. Loureiro, Moya McCarron, Robert A. W. Johnstone, M. Lurdes S. Cristiano; ESOR X, European Symposium on Organic Reactivity, Roma, July, 2005.

• Mechanistic Studies on the Photolysis of Tetrazole Derivatives in Solution; Luís M. T. Frija, Igor V. Khmelinskii, M. Lurdes S. Cristiano; 8º Encontro Nacional de Fotoquímica, SPQ, Coimbra, December 16-17, 2005.

• Infrared Spectrum and UV-Induced Photochemistry of Matrix-Isolated 5-Methoxy-1-Phenyl-Tetrazole; A. Gómez-Zavaglia, I. D. Reva, L. Frija, M. L. Cristiano and R. Fausto; 8º Encontro Nacional de Fotoquímica, SPQ, Coimbra, December 16-17, 2005.

• Matrix-isolated 5-Ethoxy-1-Phenyl-Tetrazole: Photochemistry and Vibrational Spectra; Luís M. T. Frija, I. D. Reva, A. Gómez-Zavaglia, M. L. S. Cristiano, R. Fausto; Transmediterranean Colloquium on Heterocyclic Chemistry, Aveiro, June 23-27, 2006.

• Mechanistic Investigations into the Photochemistry of 5-Allyloxy-1-phenyl-1H-tetrazoles in Solution; Luís M. T. Frija, I. V. Khmelinskii, M. Lurdes S. Cristiano, C. Serpa and R. Fausto; ESOR XI, European Symposium on Organic Reactivity, Faro, July 1-6, 2007.

• Novel Benzisothiazole-tetrazolyl Derivatives as Potential Nitrogen Ligands; Luís M. T. Frija, M. Lurdes S. Cristiano and R. Fausto; 7º Encontro Nacional de Química Orgânica, SPQ, Lisboa, July, 2007.

• Recent Advances in the Synthesis and Applications of New Saccharinate-tetrazoles as Multidentate Ligands; Luís M. T. Frija, R. M. S. Loureiro, R. Fausto and M. L. S. Cristiano; XIXth International Conference on Physical Organic Chemistry (ICPOC 19), Santiago de Compostela, July, 2008.

• Synthetic Transformation of Portuguese Natural Resources Derived from Cistus ladaniferus; Luís M. T. Frija, R. P. R. C. Carvalho and C. A. M. Afonso; 10th Tetrahedron Symposium, Paris, June, 2009.

• Amberlyst®: an Efficient and Recyclable Catalyst for the Regioselective Dehydration of Tertiary Alcohols; Luís M. T. Frija and C. A. M. Afonso; 2PYCheM, SPQ, Aveiro, April 22-24, 2010.

• More environmentally approach for the isolation of labdanolic acid from Cistus ladaniferus; André N. C. Martins, Luís M. T. Frija, S. Simeonov, Carlos A. M. Afonso; XXII Encontro Nacional da SPQ, Braga, 3-6, July, 2011.

• Isolation and quantification of labdanolic acid from Cistus ladaniferus; André N. C. Martins, Luís M. T. Frija, S. Simeonov, Carlos A. M. Afonso; 3PYCheM, SPQ, Porto, May 9-11, 2012.

• Valorization of Diterpenes Isolated from Cistus ladaniferus; Luís M. T. Frija, H. Garcia, C. Rodrigues, I. Martins, N. R. Candeias, V. André, M. T. Duarte, C. S. Pereira, C. A. M. Afonso, R. Frade, P. Fernandes; 10º Encontro Nacional de Química Orgânica, SPQ, Lisboa, September 4-6, 2013.

• A new chromatographic method for analysis of labdanolic acid; André N. C. Martins, Luís M. T. Frija, S. Simeonov, Carlos A. M. Afonso; 10º Encontro Nacional de Química Orgânica, SPQ, Lisboa, September 4-6, 2013.

• Isolation, quantification and seasonal variation of labdanolic acid from Cistus ladaniferus; André N. C. Martins, Svilen Simeonov, Luís M. T. Frija, Carlos A. M. Afonso; International Conference on Natural Products Utilization (ICNPU), Bansko, Bulgaria, 3-6 November, pp. 116, 2013.

• In an era where the chemistry has to be green…; Luís M. T. Frija; A Química na investigação da ULisboa – 1.º Encontro do Colégio de Química, Lisboa, July 20-21, 2017.

• Tetrazole-Saccharins: Ligands, Catalysts and Mutual Function; L. M. T. Frija, B. G. M. Rocha, L. Cabral, M. L. S. Cristiano, M. N. Kopylovich, A. J. L. Pombeiro; 12º Encontro Nacional de Química Orgânica, SPQ, Coimbra, January 17-19, 2018. 

• Tetrazolyl- and Thiadiazolyl-Benzisothiazole Derivatives: from Dynamic Multidentate Nitrogen Ligands in Catalysis to Selective Chelating Agents for Metals in Biological Medium; L. M. T. Frija, L. I. L. Cabral, M. L. S. Cristiano, M. N. Kopylovich, A. J. L. Pombeiro; 7th EuCheMS Conference on Nitrogen Ligands, Lisboa, September 4-7, 2018.

• 3-((2-Methyl-2H-tetrazol-5-yl)amino)benzisothiazole 1,1-dioxide: A Simple but Efficent Organocatalyst for Benzyl Alcohols Oxidation under Smooth Conditions; Bruno G. M. Rocha, Luís M. T. Frija, Maximilian N. Kopylovich, Maxim L. Kuznetsov, Lília Cabral, M. Lurdes S. Cristiano, Armando J. L. Pombeiro; 7th EuCheMS Conference on Nitrogen Ligands, Lisboa, September 4-7, 2018.

• Design, Synthesis and Application of novel Tetrazolyl- and Thiadiazolyl-Benzisothiazole Derivatives as Dynamic Multidentate Nitrogen Ligands in Catalysis and Selective Chelating Agents for Metals in Biological Medium; Luís M. T. Frija and Armando J. L. Pombeiro; CQE Days Spring Meeting, Lisboa, May 30-31, 2019.

• Nickel(II) Tetrazole-saccharinate Complex as Homogeneous Catalyst on the Reduction of Aldehydes: Scope and Reaction Mechanism; Bruno G. M. Rocha, Luís M. T. Frija, Maxim L. Kuznetsov, Lília I. L. Cabral, M. Lurdes S. Cristiano and Armando J. L. Pombeiro; Chemistry: Shaping the Future, 4º Encontro do Colégio de Química, ULisboa, Lisboa, July 16-19, 2019.

• Understanding the Molecular Structure of 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1,2-benzothiazole 1,1-dioxide. The Importance of S…N Interaction in a Thiadiazolyl-Saccharinate Derivative; L. M. T. Frija, L. I. L. Cabral, E. M. Brás, M. S. C. Henriques, C. Marques, L. Barreira, J. A. Paixão, R. Fausto and M. L. S. Cristiano; 1st International Conference on Noncovalent Interactions (ICNI-2019), Lisboa, September 2-6, 2019.

• A Facile, Efficient, and Reusable Silica Sulfuric Acid (SSA) Catalysed Synthesis of Non-Symmetrical 1,2,4,5-Tetraoxanes and 1,2,4-Trioxanes; Patrícia S. M. Amado, Luís M. T. Frija, Paul M. O’Neill, Maria L. S. Cristiano; 7PYCheM, SPQ, Bragança, May 19-21, 2021.

• A novel tetrazole-saccharinate Zn(II) catalyst acting on selective oxidation of benzyl alcohols; The role of the ligand and the reaction mechanism; Luís M. T. Frija, M. Lurdes S. Cristiano, André L. Fernandes, Armando J. L. Pombeiro; CQE Days 2021, Spring Meeting, Lisboa, May 27-28, 2021.

• Synthesis of non-symmetrical dispiro 1,2,4,5-tetraoxanes and 1,2,4-trioxanes catalyzed by Silica Sulfuric Acid; Patrícia S. M. Amado, Luís M. T. Frija, Jaime A. S. Coelho, Paul M. O’Neill and Maria L. S. Cristiano; 18th European Symposium on Organic Reactivity (ESOR2021), Online, Vrije Universiteit Amsterdam, September 21-23, 2021. (Best Poster Award)

• Solvent-free oxidation of 1-phenylethanol to acetophenone catalyzed by Cu(NO3 )2 ·2.5H2O: a fine laboratory experiment for undergraduate students; Luís Frija, Bruno G. M. Rocha, Armando J. L. Pombeiro;  CQE Days 2022, Lisboa 2022.

• Synthesis of original tetrazole-saccharinate ligands - the study of coordination properties towards different metal ions and their application in homogeneous catalytic protocols at a laboratory scale; Luís M. T. Frija; A. J. L. Pombeiro; XXII International Symposium on Homogeneous Catalysis, Lisbon, 2022.

• Hybrid azole conjugates as viable anticancer and antimicrobial agents: a preliminary biological evaluation; Luís M. T. Frija; Bruno Guerreiro; Inês Costa; Isca, Vera M. S.; Lucília Saraiva; Beatriz Neves; Mariana Magalhães; et al.; CQE Days 2023, Lisboa 2023.

• Synthesis and structure of pyrimidine-aryl-thioethers with potential antiparasitic activity: reaction mechanism and an unexpected dimethylamination of the pyrimidine heterocycle from N,N-dimethylformamide; Luís M. T. Frija, Inês C. C. Costa, André F. Augusto, José A. Paixão, Maria L. S. Cristiano; CQE Days 2024, Lisboa 2024.

• Design and Synthesis of new Hybrid Azole-type Ligands as Potencial Copper Chelators for Cancer Therapeutics; Armando J. L. Pombeiro, Luís M. T. Frija; 8th EuChems Conference on Nitrogen Ligands, Cassis (France), 3-7 June, 2024.

• A Case of Serendipity: Unexpected Reactivity in the Synthesis of a Saccharin-1,3,4-Thiadiazole Thioether;  B. Guerreiro, D. Carvalho, J. A. S. Coelho, J. A. Paixão, M. L. S. Cristiano, L. M. T. Frija; CQE Days 2025, Lisboa, May 12-13, 2025.