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ANR Project (2011-2015)
ANR Project (2011-2015)
Abstract
Abstract
Alzheimer's disease (AD) and related disorders cause cognitive changes that affect the behavior of the patient gradually limiting the activities and participation to the social life. This gradual loss of autonomy, has a close relationship with praxic disorders, especially tool use disorders, and questions the standing at home, as soon as difficulties to interact securely with the technical environment occur (ex: home appliances, hand tools). These tool use disorders can be expressed in different ways: clumsiness during manipulation (ex take the knife by the blade), use of an object instead of another (ex: use a spoon to cut meat), or doing an action at the wrong sequence moment (ex: butter a slice without putting butter on the knife). In this context, our project concerns the comprehension and the evaluation of praxic disorders. Indeed, the decision of standing at home or placement in institutions, require the existence of specific and validated tests, evaluating the nature and the severity of the disorders. If we do not question the clinical relevance that the few apraxia batteries may have, it does not exist, at the national and international level, a battery allowing the evaluation of the effective use of tools. Yet, this evaluation of the effective use of tools remains the best way to examine the difficulties of the patients at home. On the basis of the theoretical model that we developed, we propose to reconsider the assessment method of these disturbances in patients. To do this, we will built a protocol for the clinical examination containing 15 tasks, among which 6 are of effective use, divided into 6 dimensions corresponding to the different component of equipped activities. This protocol will be validated with a sample of normal subjects, and 3 patients groups: AD, semantic dementia and corticobasal degeneration, chosen for their relevance to the topic of tool use. Each subject will be evaluated 2 times at one year interval. This clinical work has two objectives. First, there is a need to specify the nature and the severity of praxis disorder in AD and related disorders, and, secondly, to propose a battery for the clinical use allowing a better diagnostic and difficulties monitoring and/or contribute to the placement in institution decision.
Project team
Project team
Didier Le Gall* (PI), Frédérique Etcharry-Bouyx*, & François Osiurak**
*Université d'Angers, Angers, France
**Université Lyon 2, Lyon, France
Other members: Christophe Jarry, Josselin Baumard, & Mathieu Lesourd
Publications linked to this project
Publications linked to this project
Baumard, J., Lesourd, M., Jarry, C., Merck, C., Etcharry-Bouyx, F., Chauviré, V., Belliard, S., Osiurak, F., & Le Gall, D. (sous presse). Knowing “What for”, but not “Where”: Dissociation between functional and contextual tool knowledge in healthy individuals and patients with dementia. Journal of the International Neuropsychological Society.
Baumard, J., Lesourd, M., Remigereau, C., Jarry, C., Etcharry-Bouyx, F., Chauviré, V., Osiurak, F., & Le Gall, D. (sous presse). Sensory integration deficits in neurodegenerative diseases: Implications for apraxia. Archives of Clinical Neuropsychology.
Baumard, J., Lesourd, M., Remigereau, C., Laurent, L., Jarry, C., Etcharry-Bouyx, F., Chauviré, V., Osiurak, F., & Le Gall, D. (2023). Meaningless imitation in neurodegenerative diseases: Effects of body part, bimanual imitation, asymmetry, and body midline crossing. Cognitive Neuropsychology, 39, 227-248.
Baumard, J., Lesourd, M., Guezouli, L., & Osiurak, F. (2021). Physical understanding in neurodegenerative diseases. Cognitive Neuropsychology, 38, 490-514.
Jarry, C., Osiurak, F., Baumard, J., Lesourd, M., Merck, C., Etxcharry-Bouyx, F., Chauviré V., Belliard, S., Moreaud, O., Croisile, B., & Le Gall, D. (2021). Daily life activities in patients with Alzheimer’s disease or semantic dementia: Multitasking assessment. Neuropsychologia, 150, 107714.
Baumard, J., Remigereau, C., Lesourd, M., Lucas, C., Jarry, C., Osiurak, F., & Le Gall, D. (2020). Imitation of meaningless gestures in normal aging. Aging, Neuropsychology, & Cognition, 27, 729-747.
Baumard, J., Lesourd, M., Remigereau, C., Merck, C., Jarry, C., Etcharry-Bouyx, F., Chauviré, V., Belliard, S., Moreaud, O., Osiurak, F., & Le Gall, D. (2019). The – weak – role of memory in tool use: Evidence from neurodegenerative diseases. Neuropsychologia, 129, 117-132.
Baumard, J., Lesourd, M., Jarry, C., Merck, C., Etcharry-Bouyx, F., Chauviré, V., Belliard, S., Moreaud, O., Croisile, B., Osiurak, F., & Le Gall, D. (2018). Tool use in neurodegenerative diseases: Planning or technical reasoning? Journal of Neuropsychology, 12, 409-426.
Lesourd, M., Baumard, J., Jarry, C., Le Gall, D., & Osiurak, F. (2017). A cognitive-based model of tool use in normal aging. Aging, Neuropsychology, & Cognition, 24, 363-386.
Lesourd, M., Baumard, J., Jarry, C., Etcharry-Bouyx, F., Belliard, S., Moreaud, O., Croisile, B., Chauviré, V., Granjon, M., Le Gall, D., & Osiurak, F. (2017). Rethinking the cognitive mechanisms underlying pantomime of tool use: Evidence from Alzheimer’s disease and semantic dementia. Journal of the International Neuropsychological Society, 23, 128-138.
Baumard, J., Lesourd, M., Jarry, C., Merck, C., Etcharry-Bouyx, F., Chauviré, V., Belliard, S., Moreaud, O., Croisile, B., Osiurak, F., & Le Gall, D. (2016). Tool use disorders in neurodegenerative diseases. Roles of semantic memory and technical reasoning. Cortex, 82, 119-132.
Lesourd, M., Baumard, J., Jarry, C., Etcharry-Bouyx, F., Belliard, S., Moreaud, O., Croisile, B., Chauviré, V., Granjon, M., Le Gall, D., & Osiurak, F. (2016). Mechanical problem-solving in Alzheimer’s disease and semantic dementia. Neuropsychology, 30, 612-623.
Le Gall, D., Jarry, C., Besnard, J., Etcharry-Bouyx, F., Baumard, J., Lesourd, M., & Osiurak, F. (2016). L’apraxie dans les pathologies neurodégénératives. Revue de Neuropsychologie, 8, 77-85.
Jarry, C., Osiurak, F., Baumard, J., Lesourd, M., Croisile, B., Etcharry-Bouyx, F., Chauviré, V., & Le Gall, D. (2016). Tool use in left brain damage and Alzheimer’s disease. What about function and manipulation knowledge? Journal of Neuropsychology, 10, 154-159.
Lesourd, M., Le Gall, D., Baumard, J., Croisile, B., Jarry, C., & Osiurak, F. (2013). Apraxie et maladie d’Alzheimer. Revue de Neuropsychologie, 5, 213-222.
Lesourd, M., Le Gall, D., Baumard, J., Croisile, B., Jarry, C., & Osiurak, F. (2013). Apraxia and Alzheimer’s disease: Review and perspectives. Neuropsychology Review, 23, 234-256.
Bohlhalter, S., & Osiurak, F. (2013). Limb apraxia in neurodegenerative diseases. Neurodegenerative Disease Management, 3, 353-361.
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