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The Infinity 2.0 Beta Pack is 3.8 GB of samples for hip hop, r&b, dancehall, and more. Inside you will find a bunch of folders containing different types of samples - melodies, vocals, drums, fx, and a folder of 96 percussion samples we recorded in a symphony concert hall.

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The most tantalizing One-Shot Log drum bass tones for Amapiano are combined in Amapiano Log Drum Bass Sample Pack. The likes of Kabza De Smallz, DJ Maphorisa, Virgo Deep, Lady Du, Focalistic, DJ Major League, and many others have inspired the careful creation of these Log Drum tones. This sample pack is royalty-free and compatible with all DAWs, samplers, and devices that support the.WAV &.MIDI file formats.

Thank you to everyone who contributed original samples over the last two years. I've listened to every sample (over 20GB of uploads in total) so as to organize and integrate only the very best 500 MB of these sounds.

The preanalytic phase has been recognized to have a substantialrole for the quality and reliability of analytical results, which very muchdepend on the type and quality of specimens provided. There are severalunique challenges to select and collect specimens for postmortem toxicologyinvestigation. Postmortem specimens may be numerous, and sample quality maybe quite variable. An overview is given on specimens routinely collected aswell as on alternative specimens that may provide additional information onthe route of administration, a long term or a recent use/exposure to a drugor poison. Autolytic and putrefactive changes limit the selection and utilityof specimens. Some data from case reports as well as experimentalinvestigations on drug degradation and/or formation during putrefaction arediscussed. Diffusion processes as well as postmortem degradation or formationmay influence ethanol concentration in autopsy specimens. Formalin fixationof specimens or embalmment of the corpse may cause considerable changes ofinitial drug levels. These changes are due to alterations of the biologicalmatrix as well as to dilution of a sample, release or degradation of the drugor poison. Most important seems a conversion of desmethyl metabolites to theparent drug. Some general requirements for postmortem sampling are givenbased on references about specimen collection issues, for a harmonizedprotocol for sampling in suspected poisonings or drug-related deaths does notexist. The advantages and disadvantages of specimen preservation are shortlydiscussed. Storage stability is another important issue to be considered.Instability can either derive from physical, chemical or metabolic processes.The knowledge on degradation mechanisms may enable the forensic toxicologistto target the fight substance, which may be a major break down product in theinvestigation of highly labile compounds. Although it is impossible toeliminate all interfering factors or influences occurring during thepreanalytic phase, their consideration should facilitate the assessment ofsample quality and the analytical result obtained from that sample.

In unnatural, sudden, violent or unexpected deaths, theinvestigator often needs evidence whether foreign compounds are present inautopsy material. Firstly, the forensic toxicologist will apply a screeningtest to establish whether there are any components of a sample not normallypresent. After confirmatory testing of a drug or poison, the quantity ofsubstance in an appropriate specimen is determined. Quantitation of thesubstance is necessary to state whether the amount of the particular compoundis compatible with fatal poisoning or more in accordance with therapeuticconcentrations in the underlying case [1]. During the last years, theavailability of advanced technical equipment as well as the development ofanalytical quality specifications have enabled continuously improvedscreening and measurement procedures to be performed on postmortem materials[2]. However, there is increasing evidence indicating that the reliability ofthe analytical results on those specimens cannot be achieved through the merepromotion in the accuracy of the analytical process [3].

In forensic medicine, a number of different factors such as theterminal events, the time interval between death and discovery of the corpse,its transportation and storage until autopsy as well as the involvement andthe cooperation of various professions such as an emergency physician, thepolice, the mortician, the pathologist and the autopsy staff including theforensic toxicologist may be considered to have a potential influence on thepreanalytic phase. In principle, most of the preanalytic prerequisites forthe quality of the samples considered in clinical chemistry will also applyto the quality of postmortem specimens. However, a lot of the preconditionswill not be within the reach of postmortem sampling and subsequenttoxicological investigation, and therefore must be regarded as unique.

In many cases, it is evident from the beginning that toxicologicalinvestigations are required due to observations and findings at the scene,reports on terminal events, the results of the police investigations, and therecords on the medical or social history of the deceased. All theseinformation enable detailed instructions for the selection of appropriate andcorrect samples even in special cases.

In a number of cases, the suspicion of poisoning or intoxicationremains elusive at the completion of police investigations and the externalexamination, and autopsy findings may be insufficient to explain the cause ofdeath. Most drug-related deaths do not leave such obvious or specific signsas those found in organ failures, cancer or trauma, for the majority of drugsand chemicals does not produce characteristic pathological findings. Often,the only indication of poisoning or intoxication is congestion of the majororgans, fluidity of postmortem blood, and edema of the lungs and the brain.Whereas these findings are not specific, in some cases, various cluesindicating poisoning or intoxication may be observed during autopsy, and inrare cases, specific signs may be present. Smell and visual appearance willbe most helpful (Table 1) [11-14]. Nevertheless, it is important that incases which have been initially handled as routine cases a selection ofappropriate postmortem samples should always be available to performtoxicological investigations (see Section 4).

If a probable death by overdose or poisoning is identified,additional questions may arise such as the route of administration, along-term or an exclusively recent use/ exposure to a drug or poison. Inthese cases, additional and alternative specimens such as hair, nails or skinsamples should have been collected to complete the toxicology investigation.In decomposed, skeletonized or embalmed cases availability of specimens islimited, therefore these cases present unique challenges for the toxicologist[15].

2.2.1.1. Blood. Blood is the specimen of choice for quantifyingand interpreting concentrations of drugs and corresponding metabolites.Quantitation is usually performed on specimens from peripheral sites, e.g.from the femoral vein. Following severe injury or trauma, samples fromdefined sources are often not available, and blood may be collected only fromthe thoracic or abdominal cavity. The composition of these specimens markedlydiffers from whole blood. Therefore, these "blood" samples onlyprovide a qualitative documentation of the presence of a drug or poison.

A positive finding may indicate very recent drug use or exposure,for many substances disappear from blood circulation fairly rapidly.Determination of the drug blood concentration is sufficient in cases where adrug concentration is clearly in the fatal range and poisoning is evidentfrom the circumstances surrounding death. Blood is also a good sample to usein cases of poisonings by gases or volatile compounds, e.g. in fatalities ofintentional or accidental inhalation of exhaust gases. In fire victims,inhalation of cyanide may have caused death before carboxy hemoglobinconcentrations had reached significance. Blood is also the appropriatespecimen in cases of some prescription medications to verify whether or notthe deceased was taking any such medication [9,11,15,16].

Cardiac versus peripheral blood: Cardiac blood is usually moreabundant than peripheral blood, and initial toxicological tests maypreferentially be performed on a heart blood sample. Drug levels in heartblood are generally higher than in femoral venous blood. For this reason, aheart blood sample would be the preferred specimen as opposed to urine forscreening of drugs that are extensively metabolized.

Distribution-redistribution phenomena: Differences in drugconcentrations in postmortem blood samples taken from different sites arewell-documented [18,20-22]. Site dependent differences can arise from anincomplete distribution of the drug or poison at the time of death, and/orfrom postmortem redistribution at the cellular level by passive diffusion orvia the vascular pathway from the major organs. The vascular pathway maydepend on the blood remaining fluid after death.

Postmortem release/diffusion of drugs from solid organs into bloodhas been demonstrated for many drugs. In methamphetamine-associated deaths,concentrations for both methamphetamine and amphetamine were higher in heartblood than in random myocardial tissue samples. It was concluded thatmethamphetamine diffusion between heart muscle and blood after death isapparent [36]. In dothiepin-associated deaths, increased drug levels in bloodsamples from the pulmonary vein reflect diffusion of dothiepin from the lungs[37]. The lungs, muscle and liver as well as drug reservoirs in the bladderand the stomach have all been evaluated as sources for postmortem diffusion.Investigations on postmortem diffusion from gastric residues in a humancadaver model using amitriptyline, paracetamol and lithium carbonate revealedhigh concentrations in liver and lungs whereas diffusion into gallbladderbile, cardiac and aortic blood was less severe [38]. Diffusion of ethanolfrom the stomach into blood is not a problem in alcohol analysis. For anintact stomach containing 400 ml 10% ethanol, contamination of a femoral veinsample was minimal [39]. However, severe blunt trauma resulting in rupture ofinternal organs, especially of the stomach, facilitates postmortem diffusionprocesses. 17dc91bb1f