October
Measuring Performance of Diagnostic Tests
Sensitivity and Specificity
Positive and Negative Predictive Values
Likelihood Ratio and Bayesian Theory
Receiver Operating Characteristic Curves
Content Outline Learning Objectives:
Know the definition and method of calculation of sensitivity, specificity, positive predictive value, and negative predictive value
Know the limitations of positive and negative predictive values in relationship to disease prevalence when comparing diagnostic tests
Know the meaning of the clinical "likelihood ratio" (LR) and its effect on post-test odds of disease
Know the interpretation and application of receiver operating characteristic (ROC) curves
Recognize the importance of an independent "gold standard" in evaluating a diagnostic test
Supplemental Reading:
Intuitive Biostatistics (4th Edition) Chapter 42