Sakaki M, Kim-Kaneyama JR*, Noguchi M, Miyauchi A, Lei XF, Kobayashi-Tanabe M, Homma M, Yamochi T, Miyazaki A, Yoshida H. 

Medium-Chain Fatty Acids Ameliorate Liver Fibrosis by Phosphorylating Hepatic Stellate Cell Forkhead Box Protein O1. 

Liver Int. 45(9):e70270. (2025)

Noguchi M, Miyauchi A, Masaki Y, Sakaki M, Lei XF, Kobayashi-Tanabe M, Miyazaki A, Aoki T, Yoshida H, Seio K, Kim-Kaneyama JR*. 

Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo.

JHEP Rep. 6(11):101195. (2024)

Pham PT, Bavuu O, Kim-Kaneyama JR, Lei XF, Yamamoto T, Otsuka K, Suto K, Kenya K, Yagi S, Yamada H, Soeki T, Shimabukuro M, Barber GN, Sata M, Fukuda D

Innate Immune System Regulated by STING, a Cytosolic DNA Sensor, Regulates Endothelial function.

J Am Heart Assoc. 12(22):e030084. (2023)

Miyauchi A, Noguchi M, Lei XF, Sakaki M, Kobayashi-Tanabe M, Haraguchi S, Miyazaki A, Kim-Kaneyama JR*.

Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13.

Sci Rep. 13(1):7446. (2023)

Miyazaki T, Taketomi Y, Higashi T, Ohtaki H, Takaki T, Ohnishi K, Hosonuma M, Kono N, Akasu R, Haraguchi S, Kim-Kaneyama JR, Otsu K, Arai H, Murakami M and Miyazaki A
Hypercholesterolemic dysregulation of calpain in lymphatic endothelial cells interferes with Treg stability and trafficking.

Arterioscler Thromb Vasc Biol. 43(2):e66-e82 (2022)

Pham PT, Fukuda D, Nishimoto S, Kim-Kaneyama JR, Lei XF, Takahashi Y, Sato T, Tanaka K, Suto K, Kawabata Y, Yamaguchi K, Yagi S, Kusunose K, Yamada H, Soeki T, Wakatsuki T, Shimada K, Kanematsu Y, Takagi Y, Shimabukuro M, Setou M, Barber GN, Sata M. 

STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases.

Eur Heart J. 42(42):4336-4348. (2021)

Gao L, Lei XF, Miyauchi A, Noguchi M, Omoto T, Haraguchi S, Miyazaki T, Miyazaki A, Kim-Kaneyama JR*.

Hic-5 is required for activation of pancreatic stellate cells and development of pancreatic fibrosis in chronic pancreatitis.

Sci Rep. 10(1):19105.(2020)*

Miyauchi A, Kim-Kaneyama JR*, Lei XF, Chang SH, Saito T, Haraguchi S, Miyazaki T, Miyazaki A.

Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5.

Sci Rep. 9(1):15770. (2019)*

Haraguchi S, Kamata M, Tokita T, Tashiro KI, Sato M, Nozaki M, Okamoto-Katsuyama M, Shimizu I, Han G, Chowdhury VS, Lei XF, Miyazaki T, Kim-Kaneyama JR, Nakamachi T, Matsuda K, Ohtaki H, Tokumoto T, Tachibana T, Miyazaki A, Tsutsui K.

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms.

Elife. 8:e45306. (2019)

Oichi T, Taniguchi Y, Soma K, Oshima Y, Yano F, Mori Y, Chijimatsu R, Kim-Kaneyama JR, Tanaka S, Saito T.

Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.

Cell Mol Life Sci. (23):4795-4809.(2019)

Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T.

Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.

Nat Commun. 10(1):1442. (2019)

Fukuda D, Nishimoto S, Aini K, Tanaka A, Nishiguchi T, Kim-Kaneyama JR, Lei XF, Masuda K, Naruto T, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Kusunose K, Yamada H, Soeki T, Imoto I, Akasaka T, Shimabukuro M, Sata M.

Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis.

J Am Heart Assoc. 8(7):e010860.(2019)

Miyazaki T, Haraguchi S, Kim-Kaneyama JR, Miyazaki A.

Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing.

FASEB J. fj201800588RR. (2018)

Nozaki M, Haraguchi S, Miyazaki T, Shigeta D, Kano N, Lei XF, Kim-Kaneyama JR, Minakata H, Miyazaki A, Tsutsui K.

Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.

Sci Rep.8(1):2167. (2018)

Omoto T, Kim-Kaneyama JR*, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.

The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.

Oncogene. 37(9):1205-1219. (2018) 

Kim Y, Lim S, Ha T, Song YH, Sohn YI, Park DJ, Paik SS, Kim-Kaneyama JR, Song MR, Leung A, Levine EM, Kim IB, Goo YS, Lee SH, Kang KH, Kim JW.

The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity.

Elife. 6. pii: e21303. (2017)

Kigawa Y, Miyazaki T, Lei XF, Kim-Kaneyama JR, Miyazaki A. Functional Heterogeneity of Nadph Oxidases in Atherosclerotic and Aneurysmal Diseases.

J Atheroscler Thromb. 24(1):1-13. (2017)

Lei XF, Fu W, Kim-Kaneyama JR*, Omoto T, Miyazaki T, Li B, Miyazaki A. Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice.

J Hepatology. 64(1):110-7. (2016)

Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR,

Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A.

Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.

J Clin Invest. 1;126(9):3417-32. (2016)

Shimabukuro M, Okawa C, Yamada H, Yanagi S, Uematsu E, Sugasawa N,

Kurobe H, Hirata Y, Kim-Kaneyama JR, Lei XF, Takao S, Tanaka Y, Fukuda D,

Yagi S, Soeki T, Kitagawa T, Masuzaki H, Sato M, Sata M.

The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe.

J Nutr Biochem. 35:66-73. (2016)

Petropoulos C, Oddou C, Emadali A, Hiriart-Bryant E, Boyault C, Faurobert E,

Vande Pol S, Kim-Kaneyama JR, Kraut A, Coute Y, Block M, Albiges-Rizo C, Destaing O.

Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes.

J Cell Biol. 213(5):585-99 (2016)

Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C,

Kim-Kaneyama JR, Sato F, Bando M, Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H,

Shimabukuro M, Sata M.

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance.

Science Advances. 2(3):e1501332 (2016)

Chang SH, Yasui T, Taketomi S, Matsumoto T, Kim-Kaneyama JR, Omiya T, Hosaka Y, Inui H, Omata Y, Yamagami R, Mori D, Yano F, Chung U, Tanaka S, Saito T.

Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability.

Osteoarthritis Cartilage. 24(4): 688-97 (2016)

Jamba A, Kondo S, Urushihara M, Nagai T, Kim-Kaneyama JR, Miyazaki A, Kagami S. 

Hydrogen Peroxide-1 inducible Clone-5 Regulates Mesangial Cell Proliferation in Proliferative Glomerulonephritis in Mice.

PLoS One. 0(4):e0122773 (2015)

Miyazaki T, Taketomi Y, Saito Y, Hosono T, Lei XF, Kim-Kaneyama JR, Arata S,Takahashi H, Murakami M, Miyazaki A.

Calpastatin Counteracts Pathological Angiogenesis by Inhibiting Suppressor of Cytokine Signaling 3 Degradation in Vascular Endothelial Cells.

Circ Res. 116(7):1170-81 (2015)

Arita-Okubo S, Kim-Kaneyama JR*, Lei XF, Fu WG, Ohnishi K, Takeya M,

Miyauchi A, Honda H, Itabe H, Miyazaki T, Miyazaki A.

Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis.

Cardiovasc Res. 105(3):361-71 (2015) 　

Kigawa Y, Miyazaki T, Lei XF, Nakamachi T, Oguchi T, Kim-Kaneyama JR, Taniyama M, Tsunawaki S, Shioda S, Miyazaki A.

NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.

Arterioscler Thromb Vasc Biol. 34(11):2413-20 (2014)

Lei XF, Kim-Kaneyama JR*, Arita-Okubo S, Offermanns S, Itabe H, Miyazaki A.

Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms.

J Am Heart Assoc. 8;3(3). (2014)

Miyazaki T, Koya T, Kigawa Y, Oguchi T, Lei XF, Kim-Kaneyama JR, Miyazaki A.

Calpain and atherosclerosis.

J Atheroscler Thromb. 20(3):228-37 (2013)

Kim-Kaneyama JR*, Miyauchi A, Lei XF, Arita S, Mino T, Takeda N, Kou K, Eto K, Yoshida T, Miyazaki T, Shioda S, Miyazaki A.

Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation at platelet aggregation in mice.

J Thromb Haemost. 10(9):1867-74 (2012)

Kim-Kaneyama JR, Lei XF, Arita S, Miyauchi A, Miyazaki T, Miyazaki A.

Hydrogen peroxide-inducible clone 5 (hic-5) as a potential therapeutic target for vascular and other disorders.

J Atheroscler Thromb. 19(7):601-7 (2012)

Koya T, Miyazaki T, Watanabe T, Shichiri M, Atsumi T, Kim-Kaneyama JR, Miyazaki A.

Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro.

Am J Physiol Heart Circ Physiol. 303(1):H96-105 (2012)

Miyazaki T, Taketomi Y, Takimoto M, Lei XF, Arita S, Kim-Kaneyama JR, Ohata H, Ota H, Murakami M, Miyazaki A.

m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.

Circulation. 124(23):2522-32 (2011)

Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama JR, Miyazaki A, Hirano T.

Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice.

Diabetologia. 54(10):2649-59 (2011)

Kim-Kaneyama JR*, Takeda N, Sasai A, Miyazaki A, Sata M, Hirabayashi T, Shibanuma M, Yamada G and Nose K

Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling.

J Mol Cell Cardiol. 50(1):77-86 (2011)  *Corresponding

Kim-Kaneyama JR*, Wachi N, Sata M, Enomoto S, Fukabori K, Shibanuma M, Nose K.

Hic-5, an adaptor protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.

Biochem Biophys Res Commun. 376(4):682-7 (2008)

Tanaka K, Sata M, Natori T, Kim-Kaneyama JR, Nose K, Shibanuma M, Hirata Y, Nagai  R.

Circulating progenitor cells contribute to neointimal formation in nonirradiated chimeric  mice. 

FASEB J. 22(2):428-36 (2007)

Kanome T, Itoh N, Ishikawa F, Mori K, Kim-Kaneyama JR, Nose K, Shibanuma M.

Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1- inducible clone involved in regulation of mitochondrial function, cell growth and cell death.

Oncogene. 26(41):5991-6001 (2007)

Mori K, Asakawa M, Hayashi M, Imura M, Ohki T, Hirao E, Kim-Kaneyama JR, Nose K, Shibanuma M.

Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex.

J Biol Chem. 281(31):22048-61 (2006)

Kim-Kaneyama JR, Suzuki W, Ichikawa K, Kohno Y, Sata M, Nose K, Shibanuma M. Uni-axial stretch regulates intracellular localization of Hic-5 expressed in smooth muscle cells in vivo.

J Cell Sci. 118:937-49 (2005)

Shibanuma M, Mori K, Kim-Kaneyama JR, Nose K.

Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-5.

Antioxid Redox Signal. 7(3-4):335-47 (2005)

Shibanuma M, Kim-Kaneyama JR, Sato S, Nose K.

A LIM protein, Hic-5, functions as a potential coactivator for Sp1.　

J Cell Biochem. 91:633-45 (2004)

Shibanuma M, Kim-Kaneyama JR, Sato S, Ishino K, Sakamoto N, Mashimo J, Nose K.

Hic-5 communicates between focal adhesions and the nucleus through oxidant sensitive nuclear export signal.

Mol Biol Cell. 14:1158-71 (2003)

Kim-Kaneyama JR, Shibanuma M, Nose K.

Transcriptional activation of c-fos gene by a LIM protein, Hic-5.

Biochem Biophys Res Commun. 299:360-5 (2002)

Kim-Kaneyama JR, Nose K, Shibanuma M.

Significance of nuclear relocalization or ERK1/2 in reactivation of c-fos transcription and DNA synthesis in senescent fibroblasts.

J Biol Chem. 275. 20685-20692 (2000)

Ishino K, Kim-Kaneyama JR, Shibanuma M, Nose K.

Specific decrease in the level of Hic-5, a focal adhesion protein, during immortalization of    mouse embryonic fibrobla sts, and its association with focal adhesion kinase.

J Cell Biochem. 76. 411-419 (2000)

*corresponding 

細胞外マトリックス研究所

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