Polyphemus appears in EPIC: The Musical during The Cyclops Saga, following Odysseus and his crew’s misstep in trusting the Winions. Directed to a seemingly safe cave, they instead find themselves trapped in the home of a ferocious cyclops. Polyphemus is introduced as a powerful and threatening presence, tending to his sheep and sealing the cave with a massive boulder, ensuring the crew cannot escape. His character combines menace and melancholy, presenting both the horror of a cannibalistic monster and the pathos of a lonely outcast.

As the saga unfolds, Odysseus must outwit the brute, who begins consuming his men. The musical nods to the classical myth, with Polyphemus being tricked by Odysseus’ false name "Nobody" and lulled into a drunken sleep. When incapacitated, Odysseus drives a burning stake into his single eye, blinding him. Despite this, Polyphemus tries to prevent their escape, hurling massive boulders toward their ship—each one a symbol of his strength, rage, and helplessness.

In the final moments of the saga, Polyphemus' anguish transforms into a curse, as he calls upon Poseidon to take vengeance. This act sets the stage for one of the major long-term conflicts in the musical: Poseidon’s wrath against Odysseus. Polyphemus is more than just a villain—he becomes the emotional spark that ignites divine retribution. His character in EPIC offers a layered retelling of the classic myth, blending dread, sorrow, and consequence into one unforgettable foe.