Eun-Seo Cho (조은서) Ph.D.
Eun-Seo Cho (조은서) Ph.D.
Postdoctoral researcher
Neuro-Instrumentation & Computational Analysis Lab (NICA Lab), KAIST
E-mail: eunseo.cho at kaist.ac.kr
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Eun-Seo Cho (Pronounced as: Un-suh Cho) is a postdoctoral researcher in the NICA Lab at KAIST. He develops optical and computational neurotechnology to understand how the brain represents information and how neural circuits compute. He received his B.S. in Biomedical Engineering from Hanyang University and his M.S. and Ph.D. in Electrical Engineering from KAIST, advised by Prof. Young-Gyu Yoon.
Research Interests
Research Interests
#Voltage imaging #Calcium imaging #Whole-brain imaging #Optical neurotechnology #Computational imaging #Computational adaptive optics #Neural decoding #Functional connectomics #Understanding neural circuits
Selected Works
Selected Works
*co-first authors
*co-first authors
[1] E.-S. Cho*, M. Eom*, S. Zhou*, et al, Three-dimensional voltage imaging in live larval zebrafish brains using fully genetically encoded voltage indicator, Scientific Reports, 2026. [Publisher Link]
TL;DR: We report a three-dimensional voltage imaging technique based on oblique plane microscopy and a fully genetically encoded voltage indicator.
[2] E.-S. Cho*, J. Park*, et al, Graph-based modeling of optical system enables adaptive optics on dynamic samples with self-calibration, iScience, 2026. [Publisher Link]
TL;DR: We report a computational adaptive optics technique that enables adaptive optics over a large field-of-view without a wavefront sensor or a guide star, by incorporating a graph-based image formation model into the wavefront estimation algorithm.
[3] E.-S. Cho*, M. Eom*, S. Zhou*, et al, In vivo imaging of voltage and calcium signals in larval zebrafish brain using line-scan confocal microscopy, In revision, 2026.
TL;DR: We report a line-scan confocal microscopy platform for both two-dimensional voltage imaging and three-dimensional calcium imaging in the live larval zebrafish brain.
[4] E.-S. Cho*, S. Han*, et al, 3DM: Deep decomposition and deconvolution microscopy for rapid neural activity imaging, Optics Express, 2021. [Publisher Link]
TL;DR: We report a fast 3-D microscopy method for imaging neuronal activity by combining a fast axial scanning method, a self-supervised network that performs robust PCA, and a deconvolution network.
[5] M. Eom*, S. Han*, P. Park*, G. Kim, E.-S. Cho, et al, Statistically unbiased prediction enables accurate denoising of voltage imaging data, Nature Methods, 2023. [Publisher Link]
TL;DR: We report a self-supervised learning algorithm that learns and utilizes spatiotemporal dependence among pixel values for denoising voltage imaging data as well as a wide-range of microscopy images.
Education
Education
KAIST
Ph.D. in Electrical Engineering
Thesis: Self-calibrating Sensorless Adaptive Optical Microscopy
Advisor: Prof. Young-Gyu Yoon
2021.03 - 2025.08
KAIST
M.S. in Electrical Engineering
Thesis: Sparse Decomposition Deconvolution Microscopy for High-speed 3-D Imaging of Neuronal Activity
Advisor: Prof. Young-Gyu Yoon
2019.02 - 2021.02
Hanyang University, Seoul, Korea
B.S. in Biomedical Engineering (Summa Cum Laude)
2015.03 - 2018.08
Experience
Experience
Postdoctoral Researcher
Neuro-Instrumentation & Computational Analysis Lab (NICA Lab), KAIST
2025.09 - Present
Research Assistant
Neuro-Instrumentation & Computational Analysis Lab (NICA Lab), KAIST
2019.02 - 2025.08
Military Service
Technical Research Personnel
2022.03 - 2025.02
Undergraduate Intern
Computational Neuroimage Analysis Lab (CNA Lab), Hanyang University
2017.03 - 2017.12
Visiting Student
Clinical Cognitive Neuroscience Center(CCNC), Seoul National University
2017.01 - 2017.02
Honors and Awards
Honors and Awards
Best Poster Award, SPIE Advanced Biophotonics Conference (ABC), 2025
Government-sponsored scholar (Graduate scholarship), 2019 - 2025
Hanyang University Graduate Award (Summa Cum Laude), 2018
Hanyang University Alumni Association President Award, 2018
Hanyang University Biomedical Engineering Capstone Design Award (3rd Prize), 2017
Hanyang University Social Services Award, 2017
Hanyang University Department of Biomedical Engineering Fund Scholarship, 2017
Hanyang-Brain Scholarship (Merit-based Scholarship), 2015 - 2017
(Semester: 2015 Fall, 2016 Spring, 2017 Spring)
Academic Service
Academic Service
Optics Letters
Reviewer
Journal of Microscopy
Reviewer
Frontiers in Behavioral Neuroscience
Reviewer
Address
LG Innovation Hall(N24), Room #4103, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea
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