at the final study follow-up date (median age, 65 years [IQR, 54-75]), the median follow-up at time of censoring was 4.5 days (IQR, 2.4-8.1). Conclusions and Relevance This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area. Introduction The first confirmed case of coronavirus disease 2019 (COVID-19) in the US was reported from Washington State on January 31, 2020.1 Soon after, Washington and California reported outbreaks, and cases in the US have now exceeded total cases reported in both Italy and China.2 The rate of infections in New York, with its high population density, has exceeded every other state, and, as of April 20, 2020, it has more than 30% of all of the US cases.3 Limited information has been available to describe the presenting characteristics and outcomes of US patients requiring hospitalization with this illness. In a retrospective cohort study from China, hospitalized patients were predominantly men with a median age of 56 years; 26% required intensive care unit (ICU) care, and there was a 28% mortality rate.4 However, there are significant differences between China and the US in population demographics,5 smoking rates,6 and prevalence of comorbidities.7 This study describes the demographics, baseline comorbidities, presenting clinical tests, and outcomes of the first sequentially hospitalized patients with COVID-19 from an academic health care system in New York. Methods The study was conducted at hospitals in Northwell Health, the largest academic health system in New York, serving approximately 11 million persons in Long Island, Westchester County, and New York City. The Northwell Health institutional review board approved this case series as minimal-risk research using data collected for routine clinical practice and waived the requirement for informed consent. All consecutive patients who were sufficiently medically ill to require hospital admission with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by positive result on polymerase chain reaction testing of a nasopharyngeal sample were included. Patients were admitted to any of 12 Northwell Health acute care hospitals between March 1, 2020, and April 4, 2020, inclusive of those dates. Clinical outcomes were monitored until April 4, 2020, the final date of follow-up. Data were collected from the enterprise electronic health record (Sunrise Clinical Manager; Allscripts) reporting database, and all analyses were performed using version 3.5.2 of the R programming language (R Project for Statistical Computing; R Foundation). Patients were considered to have confirmed infection if the initial test result was positive or if it was negative but repeat testing was positive. Repeat tests were performed on inpatients during hospitalization shortly after initial test results were available if there was a high clinical pretest probability of COVID-19 or if the initial negative test result had been judged likely to be a false-negative due to poor sample collection. Transfers from one in-system hospital to another were merged and considered as a single visit. There were no transfers into or out of the system. For patients with a readmission during the study period, data from the first admission are presented. Data collected included patient demographic information, comorbidities, home medications, triage vitals, initial laboratory tests, initial electrocardiogram results, diagnoses during the hospital course, inpatient medications, treatments (including invasive mechanical ventilation and kidney replacement therapy), and outcomes (including length of stay, discharge, readmission, and mortality). Demographics, baseline comorbidities, and presenting clinical studies were available for all admitted patients. All clinical outcomes are presented for patients who completed their hospital course at study end (discharged alive or dead). Clinical outcomes available for those in hospital at the study end point are presented, including invasive mechanical ventilation, ICU care, kidney replacement therapy, and length of stay in hospital. Outcomes such as discharge disposition and readmission were not available