Philadelphia: Lippincott-Raven, 1998. 3 Lobo A, Launer LJ, Fratiglioni L, et al. Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic diseases in the elderly research group. Neurology 2000;54(11 suppl 5):S4–9. 4 Harvey RJ, Skelton-Robinson M, Rossor MN. The prevalence and causes of dementia in people under the age of 65 years. J Neurol Neurosurg Psychiatry 2003;74:1206–9. 5 Wancata J, Musalek M, Alexandrowicz R, et al. Number of dementia sufferers in Europe between the years 2000 and 2050. Eur Psychiatry 2003;18:306–13. 6 Fratiglioni L, Launer LJ, Andersen K, et al. Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic diseases in the elderly research group. Neurology 2000;54(11 suppl 5):S10–15. 7 Miech RA, Breitner JC, Zandi PP, et al. Incidence of AD may decline in the early 90s for men, later for women: the Cache County study. Neurology 2002;58:209–18. 8 Matthews F, Brayne C, Investigators MR. The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study. PLoS Med 2005;2:e193. 9 Lander ES. The new genomics: global views of biology. Science 1996;274:536–9. 10 Strittmatter WJ, Roses AD. Apolipoprotein E and Alzheimer disease. Proc Natl Acad Sci U S A 1995;92:4725–7. 11 Breteler MM. Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective. Neurobiol Aging 2000;21:153–60. 12 Launer LJ. Demonstrating the case that AD is a vascular disease: epidemiologic evidence. Ageing Res Rev 2002;1:61–77. 13 McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer’s disease. Neurology 1984;34:939–44. 14 Launer LJ, Brock DB. Population-based studies of AD: message and methods: an epidemiologic view. Stat Med 2004;23:191–7. 15 Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56:303–8. 16 MRC CFAS Investigators. Pathological correlates of late–onset dementia in a multicentre, community–based population in England and Wales. Neuropathology group of the Medical Research Council cognitive function and ageing study (MRC CFAS). Lancet 2001;357:169–75. 17 Launer LJ. The epidemiologic study of dementia: a life-long quest? Neurobiol Aging 2005;26:335–40. 18 Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol 2005;4:487–99. 19 Kivipelto M, Helkala EL, Laakso MP, et al. Apolipoprotein E epsilon4 allele, e