En's Lab started in November 2022 as an infrastructure to deliver true value to patients with rare and intractable diseases to achieve goals throughout my medical life. Our main activities include research and development that contribute to the treatment of patients with rare diseases, providing medical-related information, and offering consultations for researchers. As a way of showing gratitude to the patients and their families who have been under our care, the professionals and experts who have guided us, and the colleagues with whom we have conducted research and work, I have established this Lab as an infrastructure to deliver true value to patients and to make everyone around us happy, including ourselves.