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An instrument is a tool, something used to construct. It's often a tool for making music. A musical saw happens to be a carpenter's tool that can be played with a violin bow (though you probably wouldn't want to play a wrench or a pair of pliers). The musical meanings of instrumental, as in "It starts with an instrumental piece" or "a jazz instrumental", are common. But the meanings "helpful", "useful", and "essential", as in "He was instrumental in getting my book published", are just as common.

An instrumental or instrumental song is music normally without any vocals, although it might include some inarticulate vocals, such as shouted backup vocals in a big band setting. Through semantic widening, a broader sense of the word song may refer to instrumentals.[1][2][3] The music is primarily or exclusively produced using musical instruments. An instrumental can exist in music notation, after it is written by a composer; in the mind of the composer (especially in cases where the composer themselves will perform the piece, as in the case of a blues solo guitarist or a folk music fiddle player); as a piece that is performed live by a single instrumentalist or a musical ensemble, which could range in components from a duo or trio to a large big band, concert band or orchestra.

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In a song that is otherwise sung, a section that is not sung but which is played by instruments can be called an instrumental interlude, or, if it occurs at the beginning of the song, before the singer starts to sing, an instrumental introduction. If the instrumental section highlights the skill, musicality, and often the virtuosity of a particular performer (or group of performers), the section may be called a "solo" (e.g., the guitar solo that is a key section of heavy metal music and hard rock songs). If the instruments are percussion instruments, the interlude can be called a percussion interlude or "percussion break". These interludes are a form of break in the song.

In commercial popular music, instrumental tracks are sometimes renderings, remixes of a corresponding release that features vocals, but they may also be compositions originally conceived without vocals. One example of a genre in which both vocal/instrumental and solely instrumental songs are produced is blues. A blues band often uses mostly songs that have lyrics that are sung, but during the band's show, they may also perform instrumental songs which only include electric guitar, harmonica, upright bass/electric bass and drum kit.

In grammar, the instrumental case (abbreviated INS or INSTR) is a grammatical case used to indicate that a noun is the instrument or means by or with which the subject achieves or accomplishes an action. The noun may be either a physical object or an abstract concept.

The instrumental case appears in Old English, Old Saxon, Georgian, Armenian, Basque, Sanskrit, and the Balto-Slavic languages. An instrumental/comitative case is arguably present in Turkish as well as in Tamil. Also, Uralic languages reuse the adessive case where available, locative case if not, to mark the same category, or comitative case (Estonian). For example, the Finnish kirjoitan kynll does not mean "I write on a pen", but "I write using a pen", even if the adessive -ll is used. In Ob-Ugric languages, the same category may also mark agents with verbs that use an ergative alignment, for instance, "I give you, using a pen".

Just as in English the preposition "with" can express instrumental ("using, by means of"), comitative ("in the company of"), and a number of other semantic relations, the instrumental case in Russian is not limited to its instrumental thematic role. It is also used to denote:

The Russian instrumental case is also used with verbs of use and control (to own, to manage, to abuse, to rule, to possess, etc.), attitude (to be proud of, to threaten (with), to value, to be interested (in), to admire, to be obsessed (with), etc.), reciprocal action (to share, to exchange), and some other verbs.

The functions of the Proto-Indo-European instrumental case were taken over by the dative, so that the Greek dative has functions belonging to the Proto-Indo-European dative, instrumental, and locative.[4] This is the case with the bare dative, and the dative with the preposition sn "with". It is possible, however, that Mycenean Greek had the instrumental case, which was later replaced by dative in all the Greek dialects.[5]

In nouns, the Old German instrumental was replaced with the dative in Middle High German, comparable with English and Ancient Greek, with a construction of mit (with) + dative clause (in English, the objective case is used). For example:

Instrumental in the Serbo-Croatian language group is usually used to denote a noun with which the action is done, e.g. "Idem autom" - "I'm going by means of a car", "Jedem vilicom/viljukom" - "I eat with a fork", "Prenosi se zrakom/vazduhom" - "It's transferred through air", "Proeta je bijesom" - "She's consumed by anger". The instrumental preposition "s(a)", meaning "with", is supposed to be dropped in this usage, but it is often kept in casual speech when talking about objects in use, such as a pen, a hammer, etc.

Instrumental can also denote company, in which case "s(a)" is mandatory, e.g. "Priali smo sa svima" - "We talked with everyone", "Doao je s roditeljima" - "He came with his parents", "etala se sa psom" - "She was taking a walk with her dog". Dropping "s(a)" in this case would either make the sentences incorrect, or change their meaning entirely because dative, locative and instrumental share the same form in the plural, so the examples "Priali smo svima" i "Doao je roditeljima" would come to mean "We told everyone" and "He came to his parents".

The instrumental case is present in the Hungarian language, where it serves several purposes. The main purpose is the same as the above, i.e. the means with which an action occurs. It has a role in the -(t)at- causative form of verbs, that is, the form of a verb that shows the subject caused someone else to action the verb. In this sense, the instrumental case is used to mark the person that was caused to execute the action expressed by the verb. It is also used to quantify or qualify words such as 'better' or 'ago', such as sokkal jobban 'much better' (literally 'with-much better'); ht vvel ezeltt 'seven years ago' (literally 'seven with-years before this').

Finnish has a historic, marginal instructive case (-n), but in practice the adessive case (-lla/-ll) is used instead outside lexicalised fixed expressions, even though the adessive literally means 'on top', e.g. vasaralla 'using a hammer' (instrumental meaning) or 'on a hammer' (locative meaning). (Vasaroin 'using hammers' is plausible and understandable, but not common in use.)

Nahuatl uses the suffix -tica to indicate the instrumental case.For example, in the sentence tln caltica in hullahqueh 'they came on the water by boat', calli means 'boat' and caltica means 'by (use of a) boat'.

The original Proto-Turkic instrumental case suffix was -n, which is less productive today but is preserved in common words like yazn ("during the summer"), kn ("during the winter"), len ("at noon"), and yayan ("by foot", "on foot"). It became less productive in most Oghuz Turkic languages. The conjunction ile ("with") in Turkish has semantically expanded to fill the gap (krek ile or krekle, meaning "with the shovel" > "using the shovel"), being used as an instrumental marker, and the suffix -(y)lA (-le, -la, -yle, -yla) is a form of ile which has been grammaticalized into an agglutinative suffix as a result of quick speech, becoming an enclitic.

The division offers Bachelor of Music, Master of Music, and Doctor of Musical Arts performance degrees with specialization in: violin, viola, violoncello, double bass, harp, guitar, flute, oboe, clarinet, bassoon, saxophone, trumpet, French horn, trombone, euphonium, tuba, percussion, and multiple woodwinds. Current and former students have won prizes in major instrumental competitions of every genre, and are appointed to professional positions in orchestras, wind symphonies, and universities/conservatories spanning the world.

Mendelian randomization is the use of genetic instrumental variables to obtain causal inferences from observational data. Two recent developments for combining information on multiple uncorrelated instrumental variables (IVs) into a single causal estimate are as follows: (i) allele scores, in which individual-level data on the IVs are aggregated into a univariate score, which is used as a single IV, and (ii) a summary statistic method, in which causal estimates calculated from each IV using summarized data are combined in an inverse-variance weighted meta-analysis. To avoid bias from weak instruments, unweighted and externally weighted allele scores have been recommended. Here, we propose equivalent approaches using summarized data and also provide extensions of the methods for use with correlated IVs. We investigate the impact of different choices of weights on the bias and precision of estimates in simulation studies. We show that allele score estimates can be reproduced using summarized data on genetic associations with the risk factor and the outcome. Estimates from the summary statistic method using external weights are biased towards the null when the weights are imprecisely estimated; in contrast, allele score estimates are unbiased. With equal or external weights, both methods provide appropriate tests of the null hypothesis of no causal effect even with large numbers of potentially weak instruments. We illustrate these methods using summarized data on the causal effect of low-density lipoprotein cholesterol on coronary heart disease risk. It is shown that a more precise causal estimate can be obtained using multiple genetic variants from a single gene region, even if the variants are correlated. 2351a5e196