Publication
2023
Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.
Ono Y, Kawakami K, Nakamura G, Ishida S, Aoki J, Inoue A.
Commun Biol. (2023) 6:112.
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
Tatsumi M, Kishi T, Ishida S, Kawana H, Uwamizu A, Ono Y, Kawakami K, Aoki J, Inoue A.
PLoS One. (2023 ) 18:e0280448.
Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84.
Ohue-Kitano R, Nonaka H, Nishida A, Masujima Y, Takahashi D, Ikeda T, Uwamizu A, Tanaka M, Kohjima M, Igarashi M, Katoh H, Tanaka T, Inoue A, Suganami T, Hase K, Ogawa Y, Aoki J, Kimura I.
JCI Insight. (2023) 8:e165469.
Constitutively active GPR43 is crucial for proper leukocyte differentiation.
Miyasato S, Iwata K, Mura R, Nakamura S, Yanagida K, Shindou H, Nagata Y, Kawahara M, Yamaguchi S, Aoki J, Inoue A, Nagamune T, Shimizu T, Nakamura M.
FASEB J. (2023) 37:e22676.
Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes With Regulatory T-Cell Stability and Trafficking.
Miyazaki T, Taketomi Y, Higashi T, Ohtaki H, Takaki T, Ohnishi K, Hosonuma M, Kono N, Akasu R, Haraguchi S, Kim-Kaneyama JR, Otsu K, Arai H, Murakami M, Miyazaki A.
Arterioscler Thromb Vasc Biol. (2023 ) 43:e66-e82.
2022
Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase.
Kawana H, Ozawa M, Shibata T, Onishi H, Sato Y, Kano K, Shindou H, Shimizu T, Kono N, Aoki J.
J Lipid Res. (2022) 63:100271.
Supercritical fluid chromatography-mass spectrometry enables simultaneous measurement of all phosphoinositide regioisomers.
Shimanaka Y, Matsumoto K, Tanaka Y, Ishino Y, Ni S, Guan JL, Arai H, Kono N.
Commun Chem. (2022) 5:61.
Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish.
Shibata T, Kawana H, Nishino Y, Ito Y, Sato H, Onishi H, Kano K, Inoue A, Taketomi Y, Murakami M, Kofuji S, Nishina H, Miyazawa A, Kono N, Aoki J.
Sci Rep. (2022) 12:7312.
Current Knowledge on Mammalian Phospholipase A1, Brief History, Structures, Biochemical and Pathophysiological Roles.
Yaginuma S, Kawana H, Aoki J.
Molecules. (2022) 27:2487.
The Many Roles of Lysophospholipid Mediators and Japanese Contributions to This Field.
Takagi Y, Nishikado S, Omi J, Aoki J.
Biol Pharm Bull. (2022) 45:1008-1021.
Lysophospholipid Mediators in Health and Disease.
Kano K, Aoki J, Hla T.
Annu Rev Pathol. (2022) 17:459-483.
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity.
Valentine WJ, Yanagida K, Kawana H, Kono N, Noda NN, Aoki J, Shindou H.
J Biol Chem. (2022) 298:101470.
Phenotypic evaluation of constitutive GPCR/G-protein signaling in zebrafish embryos and larvae.
Shibata T, Kawakami K, Kawana H, Aoki J, Inoue A.
Biochem Biophys Res Commun. (2022) 602:70-76.
Modulations of bioactive lipids and their receptors in postmortem Alzheimer's disease brains.
Kurano M, Saito Y, Uranbileg B, Saigusa D, Kano K, Aoki J, Yatomi Y.
Front Aging Neurosci. (2022) 14:1066578.
Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling.
Moriyama H, Endo J, Kataoka M, Shimanaka Y, Kono N, Sugiura Y, Goto S, Kitakata H, Hiraide T, Yoshida N, Isobe S, Yamamoto T, Shirakawa K, Anzai A, Katsumata Y, Suematsu M, Kosaki K, Fukuda K, Arai H, Sano M.
Nat Commun. (2022) 13:3013.
Sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids.
Uranbileg B, Kurano M, Kano K, Sakai E, Arita J, Hasegawa K, Nishikawa T, Ishihara S, Yamashita H, Seto Y, Ikeda H, Aoki J, Yatomi Y.
Clin Transl Med. (2022) 12:e1056.
Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation.
Kondo N, Sakurai Y, Takata T, Kano K, Kume K, Maeda M, Takai N, Suzuki S, Eto F, Kikushima K, Wanibuchi H, Miyatake SI, Kajihara T, Oda S, Setou M, Aoki J, Suzuki M.
Sci Rep. (2022) 2:8718.
Changes in Lysophospholipid Components in Ulcerative Colitis and Colitis-associated Cancer.
Sonoda H, Kitamura C, Kano K, Anzai H, Nagai Y, Abe S, Yokoyama Y, Ishii H, Kishikawa J, Murono K, Emoto S, Sasaki K, Kawai K, Nozawa H, Aoki J, Ishihara S.
Anticancer Res. (2022) 42:2461-2468.
LPA6-RhoA signals regulate junctional complexes for polarity and morphology establishment of maturation stage ameloblasts.
Inaba A, Harada H, Ikezaki S, Kumakami-Sakano M, Arai H, Azumane M, Ohshima H, Morikawa K, Kano K, Aoki J, Otsu K.
J Oral Biosci. (2022) 64:85-92.
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.
Kawakami K, Yanagawa M, Hiratsuka S, Yoshida M, Ono Y, Hiroshima M, Ueda M, Aoki J, Sako Y, Inoue A.
Nat Commun. (2022) 3:487.
Decrease in serum levels of autotaxin in COVID-19 patients.
Shimura T, Kurano M, Okamoto K, Jubishi D, Hashimoto H, Kano K, Igarashi K, Shimamoto S, Aoki J, Moriya K, Yatomi Y.
Ann Med. (2022) 54:3189-3200.
Different Profiles of the Triad of Lysophosphatidylcholine, Lysophosphatidic Acid, and Autotaxin in Patients with Neuropathic Pain Diseases: a Preliminary Observational Study.
Edamura T, Sumitani M, Hayakawa K, Inoue R, Abe H, Tsuchida R, Chikuda H, Ogata T, Kurano M, Aoki J, Yatomi Y, Uchida K.
Pain Ther. (2022) 11:1439-1449.
Dynamic modulations of urinary sphingolipid and glycerophospholipid levels in COVID-19 and correlations with COVID-19-associated kidney injuries.
Kurano M, Jubishi D, Okamoto K, Hashimoto H, Sakai E, Morita Y, Saigusa D, Kano K, Aoki J, Harada S, Okugawa S, Doi K, Moriya K, Yatomi Y.
J Biomed Sci. (2022) 29:94.
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19.
Kurano M, Okamoto K, Jubishi D, Hashimoto H, Sakai E, Saigusa D, Kano K, Aoki J, Harada S, Okugawa S, Doi K, Moriya K, Yatomi Y.
Clin Transl Med. (2022) 12:e1069.
Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma.
Kudo K, Miki Y, Carreras J, Nakayama S, Nakamoto Y, Ito M, Nagashima E, Yamamoto K, Higuchi H, Morita SY, Inoue A, Aoki J, Ando K, Nakamura N, Murakami M, Kotani A.
Cell Metab. (2022) 34:615-633.e8.
Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses.
Hoshino Y, Okuno T, Saigusa D, Kano K, Yamamoto S, Shindou H, Aoki J, Uchida K, Yokomizo T, Ito N.
FASEB J. (2022) 36:e22236.
TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.
Petkevicius K, Palmgren H, Glover MS, Ahnmark A, Andréasson AC, Madeyski-Bengtson K, Kawana H, Allman EL, Kaper D, Uhrbom M, Andersson L, Aasehaug L, Forsström J, Wallin S, Ahlstedt I, Leke R, Karlsson D, González-King H, Löfgren L, Nilsson R, Pellegrini G, Kono N, Aoki J, Hess S, Sienski G, Pilon M, Bohlooly-Y M, Maresca M, Peng XR.
Nat Commun. (2022) 13:6020.
Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Zhang Z, Nomura N, Muramoto Y, Ekimoto T, Uemura T, Liu K, Yui M, Kono N, Aoki J, Ikeguchi M, Noda T, Iwata S, Ohto U, Shimizu T.
Nat Commun. (2022) 13:4399.
Tricalbin proteins regulate plasma membrane phospholipid homeostasis.
Thomas FB, Omnus DJ, Bader JM, Chung GH, Kono N, Stefan CJ.
Life Sci Alliance. (2022) 5:e202201430. d
Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation.
Kanemitsu E, Zhao X, Iwaisako K, Inoue A, Takeuchi A, Yagi S, Masumoto H, Ohara H, Hosokawa M, Awaya T, Aoki J, Hatano E, Uemoto S, Hagiwara M.
Transl Res. (2022 ) S1931-5244(22)00245-6.
Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism.
Yoshida Y, Shimizu I, Shimada A, Nakahara K, Yanagisawa S, Kubo M, Fukuda S, Ishii C, Yamamoto H, Ishikawa T, Kano K, Aoki J, Katsuumi G, Suda M, Ozaki K, Yoshida Y, Okuda S, Ohta S, Okamoto S, Minokoshi Y, Oda K, Sasaoka T, Abe M, Sakimura K, Kubota Y, Yoshimura N, Kajimura S, Zuriaga M, Walsh K, Soga T, Minamino T.
Sci Rep. (2022) 12:14883.
Introducing the Lipidomics Minimal Reporting Checklist.
McDonald JG, Ejsing CS, Kopczynski D, Holčapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brügger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Köfeler HC, Mitchell TW, O'Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K.
Nat Metab. (2022) 4:1086-1088.
Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy.
Kawanabe-Matsuda H, Takeda K, Nakamura M, Makino S, Karasaki T, Kakimi K, Nishimukai M, Ohno T, Omi J, Kano K, Uwamizu A, Yagita H, Boneca IG, Eberl G, Aoki J, Smyth MJ, Okumura K.
Cancer Discov. (2022) 12:1336-1355.
Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease.
Yoshioka K, Hirakawa Y, Kurano M, Ube Y, Ono Y, Kojima K, Iwama T, Kano K, Hasegawa S, Inoue T, Shimada T, Aoki J, Yatomi Y, Nangaku M, Inagi R.
Kidney Int. (2022) 101:510-526.
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.
Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata SI, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, Kunisawa J.
Mucosal Immunol. (2022) 15:289-300.
2021
Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification.
Kano K, Matsumoto H, Kono N, Kurano M, Yatomi Y, Aoki J.
J Lipid Res. (2021) 62:100029.
Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag.
Iwama T, Kano K, Saigusa D, Ekroos K, van Echten-Deckert G, Vogt J, Aoki J.
Anal Chem. (2021) 93:3867-3875.
Tanaka Y, Shimanaka Y, Caddeo A, Kubo T, Mao Y, Kubota T, Kubota N, Yamauchi T, Mancina RM, Baselli G, Luukkonen P, Pihlajamäki J, Yki-Järvinen H, Valenti L, Arai H, Romeo S, Kono N.
Gut. (2021) 70:180-193.
N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand.
Ogawa A, Nagiri C, Shihoya W, Inoue A, Kawakami K, Hiratsuka S, Aoki J, Ito Y, Suzuki T, Suzuki T, Inoue T, Nureki O, Tanihara H, Tomizawa K, Wei FY.
Mol Cell. (2021) 81:659-674.e7.
Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells.
Nishimura T, Oyama T, Hu HT, Fujioka T, Hanawa-Suetsugu K, Ikeda K, Yamada S, Kawana H, Saigusa D, Ikeda H, Kurata R, Oono-Yakura K, Kitamata M, Kida K, Hikita T, Mizutani K, Yasuhara K, Mimori-Kiyosue Y, Oneyama C, Kurimoto K, Hosokawa Y, Aoki J, Takai Y, Arita M, Suetsugu S.
Dev Cell. (2021) 56:842-859.e8.
Understanding the underlying molecular pathways by which Mboat7/Lpiat1 depletion induces hepatic steatosis.
Tavaglione F, Kono N, Romeo S.
J Lipid Res. (2021) 62:100047.
S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.
Toyomoto M, Inoue A, Iida K, Denawa M, Kii I, Ngako Kadji FM, Kishi T, Im D, Shimamura T, Onogi H, Yoshida S, Iwata S, Aoki J, Hosoya T, Hagiwara M.
Cell Chem Biol. (2021) S2451-9456(21)00004-0.
Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis.
Uranbileg B, Ito N, Kurano M, Kano K, Uchida K, Sumitani M, Aoki J, Yatomi Y.
Sci Rep. (2021) 11:3984.
Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer's disease mouse model.
Fujita Y, Kano K, Kishino S, Nagao T, Shen X, Sato C, Hatakeyama H, Ota Y, Niibori S, Nomura A, Kikuchi K, Yasuno W, Takatori S, Kikuchi K, Sano Y, Tomita T, Suzuki T, Aoki J, Zou K, Natori S, Komano H.
Sci Rep. (2021) 11:9749.
2020
Establishment of a Measurement System for Sphingolipids in the Cerebrospinal Fluid Based on Liquid Chromatography-Tandem Mass Spectrometry, and Its Application in the Diagnosis of Carcinomatous Meningitis.
Sakai E, Kurano M, Morita Y, Aoki J, Yatomi Y.
J Appl Lab Med. (2020) 5:656-670.
Urinary autotaxin concentrations are associated with kidney injury.
Morita Y, Kurano M, Morita E, Shimamoto S, Igarashi K, Sawabe M, Aoki J, Yatomi Y.
Clin Chim Acta. (2020) 509:156-165.
Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein- Coupled Receptors.
Nakamura S, Sayama M, Uwamizu A, Jung S, Ikubo M, Otani Y, Kano K, Omi J, Inoue A, Aoki J, Ohwada T.
J Med Chem. (2020) 63:9990-10029.
The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.
Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J, Iwata S.
Structure. (2020) 28:418-425.
Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.
Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O.
Nat Struct Mol Biol. (2020) 27:274-280.
Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain.
Kawaguchi M, Okabe T, Okudaira S, Hama K, Kano K, Nishimasu H, Nakagawa H, Ishitani R, Kojima H, Nureki O, Aoki J, Nagano T.
J Med Chem. (2020) 63:3188-3204.
Kajitani N, Okada-Tsuchioka M, Kano K, Omori W, Boku S, Aoki J, Takebayashi M. Differential anatomical and cellular expression of lysophosphatidic acid receptor 1 in adult mouse brain.
Biochem Biophys Res Commun. (2020) 531:89-95.
Antioxidant vitamins and lysophospholipids are critical for inducing mouse spermatogenesis under organ culture conditions.
Sanjo H, Yao T, Katagiri K, Sato T, Matsumura T, Komeya M, Yamanaka H, Yao M, Matsuhisa A, Asayama Y, Ikeda K, Kano K, Aoki J, Arita M, Ogawa T.
FASEB J. (2020) 34:9480-9497.
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex.
Maeda S, Xu J, N Kadji FM, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK.
Science. (2020) 369:161-167.
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.
Pfeil EM, Brands J, Merten N, Vögtle T, Vescovo M, Rick U, Albrecht IM, Heycke N, Kawakami K, Ono Y, Ngako Kadji FM, Hiratsuka S, Aoki J, Häberlein F, Matthey M, Garg J, Hennen S, Jobin ML, Seier K, Calebiro D, Pfeifer A, Heinemann A, Wenzel D, König GM, Nieswandt B, Fleischmann BK, Inoue A, Simon K, Kostenis E.
Mol Cell. (2020) 80:940-954.e6.
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone.
Im D, Inoue A, Fujiwara T, Nakane T, Yamanaka Y, Uemura T, Mori C, Shiimura Y, Kimura KT, Asada H, Nomura N, Tanaka T, Yamashita A, Nango E, Tono K, Kadji FMN, Aoki J, Iwata S, Shimamura T.
Nat Commun. 2020 11:6442.
Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures.
Liebisch G, Fahy E, Aoki J, Dennis EA, Durand T, Ejsing CS, Fedorova M, Feussner I, Griffiths WJ, Köfeler H, Merrill AH Jr, Murphy RC, O'Donnell VB, Oskolkova O, Subramaniam S, Wakelam MJO, Spener F.
J Lipid Res. (2020) 61:1539-1555.
Human adiponectin receptor AdipoR1 assumes closed and open structures.
Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Kano K, Kawana H, Hato M, Nakamura Y, Terada T, Kimura-Someya T, Shirouzu M, Kawano Y, Yamamoto M, Aoki J, Yamauchi T, Kadowaki T, Yokoyama S.
Commun Biol. (2020) 3:446.
Identification of novel biomarkers of hepatocellular carcinoma by high-definition mass spectrometry: Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging.
Nagai K, Uranbileg B, Chen Z, Fujioka A, Yamazaki T, Matsumoto Y, Tsukamoto H, Ikeda H, Yatomi Y, Chiba H, Hui SP, Nakazawa T, Saito R, Koshiba S, Aoki J, Saigusa D, Tomioka Y.
Rapid Commun Mass Spectrom. (2020) 34 :e8551.
Analysis of urinary sphingolipids using liquid chromatography-tandem mass spectrometry in diabetic nephropathy.
Morita Y, Kurano M, Sakai E, Nishikawa T, Nishikawa M, Sawabe M, Aoki J, Yatomi Y.
J Diabetes Investig. (2020) 11:441-449.
Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism.
Nakawatari K, Kurano M, Araki O, Nishikawa M, Shimamoto S, Igarashi K, Aoki J, Murakami M, Yatomi Y.
Clin Chim Acta. (2020) 503:99-106.
Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach. Sayama M, Uwamizu A, Otani Y, Inoue A, Aoki J, Sekijima M, Ohwada T.
Biochemistry. (2020) 59:1173-1201.
Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis.
Ninou I, Sevastou I, Magkrioti C, Kaffe E, Stamatakis G, Thivaios S, Panayotou G, Aoki J, Kollias G, Aidinis V.
PLoS One. (2020) 15:e0226050.
Metabolic Dysregulation of the Lysophospholipid/Autotaxin Axis in the Chromosome 9p21 Gene SNP rs10757274.
Meckelmann SW, Hawksworth JI, White D, Andrews R, Rodrigues P, O'Connor A, Alvarez-Jarreta J, Tyrrell VJ, Hinz C, Zhou Y, Williams J, Aldrovandi M, Watkins WJ, Engler AJ, Lo Sardo V, Slatter DA, Allen SM, Acharya J, Mitchell J, Cooper J, Aoki J, Kano K, Humphries SE, O'Donnell VB.
Circ Genom Precis Med. (2020) 13:e002806.
Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.
Lukasheva V, Devost D, Le Gouill C, Namkung Y, Martin RD, Longpré JM, Amraei M, Shinjo Y, Hogue M, Lagacé M, Breton B, Aoki J, Tanny JC, Laporte SA, Pineyro G, Inoue A, Bouvier M, Hébert TE.
Sci Rep. (2020) 10:8779.
Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1).Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Isobe S, Moriyama H, Goto S, Shimanaka Y, Kono N, Arai H, Shinmura K, Fukuda K, Sano M.Biochem Biophys Res Commun. 526:122-127 (2020).
trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop.Hirata Y, Inoue A, Suzuki S, Takahashi M, Matsui R, Kono N, Noguchi T, Matsuzawa A.Sci Rep. 10:2743 (2020).
Arii J, Fukui A, Shimanaka Y, Kono N, Arai H, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Kawaguchi Y. Role of Phosphatidylethanolamine Biosynthesis in Herpes Simplex Virus 1-Infected Cells in Progeny Virus Morphogenesis in the Cytoplasm and in Viral Pathogenicity In Vivo.J Virol. (2020) 94:e01572-20.
2019
Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P(2) Synthesis.Nishimura T, Gecht M, Covino R, Hummer G, Surma MA, Klose C, Arai H, Kono N, Stefan CJ.Mol Cell. 75:1043-1057 (2019).Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and itsTMEM16K-dependent redistribution. Tsuji T, Cheng J, Tatematsu T, Ebata A, Kamikawa H, Fujita A, Gyobu S, Segawa K, Arai H, Taguchi T, Nagata S, Fujimoto T. Proc Natl Acad Sci U S A. 116:13368-13373 (2019).
Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload.Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Yoshida N, Isobe S, Moriyama H, Goto S, Yamashita K, Ohto-Nakanishi T, Nakanishi H, Shimanaka Y, Kono N, Shinmura K, Arai H, Fukuda K, Sano M.J Mol Cell Cardiol. 133:1-11 (2019).
Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory. Takahashi K, Yanai S, Takisawa S, Kono N, Arai H, Nishida Y, Yokota T, Endo S, Ishigami A. Arch Biochem Biophys. 663:120-128 (2019).
2018
Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction. Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, YoshidaN, Isobe S, Moriyama H, Goto S, Yamashita K, Nakanishi H, Shimanaka Y, Kono N,Shinmura K, Arai H, Fukuda K, Sano M.PLoS One. 13:e0208396 (2018). Reelin deficiency leads to aberrant lipid composition in mouse brain.Mizukami T, Ikeda K, Shimanaka Y, Korogi K, Zhou C, Takase H, Tsuiji H, Kono N, Kohno T, Arai H, Arita M, Hattori M. Biochem Biophys Res Commun. 505:81-86 (2018).
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK. Proc Natl Acad Sci U S A. 115:E7768-E7775 (2018).
Platelet-activating factor acetylhydrolases: An overview and update. Kono N, Arai H.Biochim Biophys Acta Mol Cell Biol Lipids. 1864:922-931 (2019).
The binding of TBK1 to STING requires exocytic membrane traffic from the ER.Ogawa E, Mukai K, Saito K, Arai H, Taguchi T. Biochem Biophys Res Commun. 503:138-145 (2018).
2017
Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura SI, Natsume T, Miyamura N, Nishina H, Nakayama J, Semba K, Tomita T, Murata S, Arai H, Taguchi T.Nat Commun. 8:1246 (2017). Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.Shimanaka Y, Kono N, Taketomi Y, Arita M, Okayama Y, Tanaka Y, Nishito Y, Mochizuki T, Kusuhara H, Adibekian A, Cravatt B, Murakami M, Arai H.Nat Med. 23: 1287-1297 (2017).
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains.Nishimura T, Tamura N, Kono N, Shimanaka Y, Arai H, Yamamoto H, Mizushima N. EMBO J. 36:1719-1735 (2017).
Lysophosphatidylcholine export by human ABCA7. Tomioka M, Toda Y, Mañucat NB, Akatsu H, Fukumoto M, Kono N, Arai H, Kioka N, Ueda K. Biochim Biophys Acta.1862:658-665 (2017).
LYCAT controls specific phosphoinositides and related membrane traffic. Bone LN, Dayam RM, Lee M, Kono N, Fairn GD, Arai H, Botelho RJ, Antonescu CN. The acyltransferase Mol Biol Cell. 28:161-172 (2017).
2016
Activation of STING requires palmitoylation at the Golgi.Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, Barber G, Arai H, Taguchi T.Nature Communications. 7:11932 (2016).
Lysophosphatidylcholine acyltransferase 1protects against cytotoxicity induced by polyunsaturated fatty acids.Akagi S, Kono N, Ariyama H, Shindou H, Shimizu T, Arai H.FASEB J. 30, 2027-2039 (2016).
Endomembrane-associated RSD-3 is important for RNAi induced by extracellular silencing RNA in both somatic and germ cells of Caenorhabditis elegans.Imae R, Dejima K, Kage-Nakadai E, Arai H, Mitani S.Sci Rep. 6:28198 (2016).
Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans. Ishii T, Funato Y, Hashizume O, Yamazaki D, Hirata Y, Nishiwaki K, Kono N, Arai H, Miki H. PLoS Genet. 12:e1006276 (2016).
Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase. Morita J, Kano K, Kato K, Takita H, Sakagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J. Sci Rep. 6:20995 (2016).
Age-related changes of vitamin E: α-tocopherol levels in plasma and various tissues of mice and hepatic α-tocopherol transfer protein.Takahashi K, Takisawa S, Shimokado K, Kono N, Arai H, Ishigami A. Eur J Nutr. 56:1317-1327 (2016).
Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites. Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N. Stem Cells. 34:470-82 (2016).
2015
Transport of cholera toxin B-subunit from recycling endosomes to the Golgi requires clathrin and AP-1.Matsudaira T, Niki T, Taguchi T, Arai H.J Cell Sci. 128, 3131-3142 (2015).Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.Lee S, Uchida Y, Wang J, Matsudaira T, Nakagawa T, Kishimoto T, Mukai K, Inaba T, Kobayashi T, Molday RS, Taguchi T, Arai H.EMBO J. 34, 669-688 (2015).
Endosomal lipid flippases and their related diseases. Lee S, Taguchi T, Arai H.Channels (Austin). 9:166-8 (2015).
Intracellular transport of fat-soluble vitamins A and E.Kono N, Arai H. Traffic. 16:19-34 (2015).
Intracellular Platelet-Activating Factor Acetylhydrolase, Type II: A Unique Cellular Phospholipase A2 That Hydrolyzes Oxidatively Modified Phospholipids. Kono N, Arai H. Enzymes. 38:43-54 (2015).
Intracellular PAF-Acetylhydrolase Type I.Hattori M, Arai H. Enzymes. 38:23-36 (2015).
Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E. Morley S, Thakur V, Danielpour D, Parker R, Arai H, Atkinson J, Barnholtz-Sloan J, Klein E, Manor D. J Biol Chem. 290:25848 (2015).
Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells.Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, Ueda K. J Lipid Res. 56:1880-90 (2015).
Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. Sci Rep. 5:9750 (2015).
Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, Araki N, Arai H, Ueda N. J Biol Chem. 290:17520-34 (2015).
Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.Morita M, Sekine A, Urano Y, Nishimura T, Takabe W, Arai H, Hamakubo T, Kodama T, Noguchi N. J Biochem. 158:331-8 (2015).
ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner. Zhao Y, Ishigami M, Nagao K, Hanada K, Kono N, Arai H, Matsuo M, Kioka N, Ueda K. J Lipid Res. 56:644-52 (2015).
Visualization of the heterogeneous membrane distribution of sphingomyelin associated with cytokinesis, cell polarity, and sphingolipidosis. Makino A, Abe M, Murate M, Inaba T, Yilmaz N, Hullin-Matsuda F, Kishimoto T, Schieber NL, Taguchi T, Arai H, Anderluh G, Parton RG, Kobayashi T. FASEB J. 29:477-93 (2015).
「エンドソームの多彩な機能」監修 田口友彦細胞工学 Vol.34, No.2, 2015
2014
Retrograde Membrane Traffic and Recycling Endosome.Takeda Y, Taguchi T.Glycoscience: Biology and Medicine. pp 1-6 (2014).Lipid compartmentalization in the endosome system.Hullin-Matsuda F, Taguchi T, Greimel P, Kobayashi T.Semin Cell Dev Biol. 31, 48-56 (2014).
Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.Maekawa M, Terasaka S, Mochizuki Y, Kawai K, Ikeda Y, Araki N, Skolnik EY, Taguchi T, Arai H.Proc Natl Acad Sci U S A. 111, E978-87 (2014).
Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family. Udagawa O, Ito C, Ogonuki N, Sato H, Lee S, Tripvanuntakul P, Ichi I, Uchida Y, Nishimura T, Murakami M, Ogura A, Inoue T, Toshimori K, Arai H. Genes Cells. 19:13-27 (2014).
Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency. Ichi I, Kono N, Arita Y, Haga S, Arisawa K, Yamano M, Nagase M, Fujiwara Y, Arai H. Biochim Biophys Acta. 1841:204-13 (2014).
18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling. Endo J, Sano M, Isobe Y, Fukuda K, Kang JX, Arai H, Arita M. J Exp Med. 211:1673-87 (2014).
Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite. Yokokura Y, Isobe Y, Matsueda S, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H, Arita M. J Biochem. 156:315-21 (2014).
Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M. FASEB J. 28:4036-43 (2014).
Eicosapentaenoic acid is converted via ω-3 epoxygenation to the anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid. Kubota T, Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H.FASEB J. 28:586-93 (2014).
Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation. Egami Y, Taguchi T, Maekawa M, Arai H, Araki N. Front Physiol. 5:374 (2014).
Stearoyl-CoA desaturase 1 activity is required for autophagosome formation. Ogasawara Y, Itakura E, Kono N, Mizushima N, Arai H, Nara A, Mizukami T, Yamamoto A. J Biol Chem. 289:23938-50 (2014).
2013
Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth.Yamashita A, Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Arimoto T, Oda K, Wada-Hiraike O, Yamashita T, Taketani Y, Kang JX, Kozuma S, Arai H, Arita M, Osuga Y, Fujii T.Sci Rep. 3, 3113 (2013).Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition.Kishino S, Takeuchi M, Park SB, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J.Proc Natl Acad Sci U S A. 110, 17808-13 (2013).
Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs.Nishimura T, Uchida Y, Yachi R, Kudlyk T, Lupashin V, Inoue T, Taguchi T, Arai H.Mol Biol Cell. 24 ,3534-44 (2013).
Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models.Tomio K, Kawana K, Taguchi A, Isobe Y, Iwamoto R, Yamashita A, Kojima S, Mori M, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T.PLoS One. 8, e73085 (2013).
Saturated fatty acid palmitate aggravates neointima formation by promoting smooth muscle phenotypic modulation.Shen H, Eguchi K, Kono N, Fujiu K, Matsumoto S, Shibata M, Oishi-Tanaka Y, Komuro I, Arai H, Nagai R, Manabe I.Arterioscler Thromb Vasc Biol. 33, 2596-607 (2013).
SMAP2 Regulates Retrograde Transport from Recycling Endosomes to the Golgi.Matsudaira T, Uchida Y, Tanabe K, Kon S, Watanabe T, Taguchi T, and Arai H.PLoS One. 8, e69145 (2013).
Membrane lipid saturation activates IRE1α without inducing clustering.Kitai Y, Ariyama H, Kono N, Oikawa D, Iwawaki T, and Arai H.Genes Cells, 18, 798-809 (2013) Emerging roles of recycling endosomes.Taguchi T.J. Biochem., 2013153, 505-10 (2013). Impaired α-TTP-PIPs interaction underlies familial vitamin E deficiency.Kono N, Ohto U, Hiramatsu T, Urabe M, Uchida Y, Satow Y and Arai H.Science. 340 1106-1110 (2013) full text Mitochondria-type GPAT is required for mitochondrial fusion.Ohba Y, Sakuragi T, Kage-Nakadai E, Tomioka NH, Kono N, Imae R, Inoue A, Aoki J, Ishihara N, Inoue T, Mitani S and Arai H.EMBO J., 32, 1265-1279 (2013) Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein.Hirata Y, Yamamori N, Kono N, Lee HC, Inoue T and Arai H.Genes Cells., 18, 397-409 (2013) Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3.Isobe Y, Arita M, Iwamoto R, Urabe D, Todoroki H, Masuda K, Inoue M, and Arai H.J. Biochem., 153, 355-360 (2013). A method for determination of UDP-GlcNAc: GlcNAcβ1-6(GlcNAcβ1-2)Manα1-R [GlcNAc to Man] β1-4N-acetylglucosaminyltransferase VI activity.Taguchi T, Taniguchi N.Methods Mol. Biol. 1022, 299-305 (2013) Inflammation and resolution are associated with upregulation of fatty acid β-oxidation in Zymosan-induced peritonitis.Fujieda Y, Manno A, Hayashi Y, Rhodes N, Guo L, Arita M, Bamba T and Fukusaki E.PLoS One. 8, e66270 (2013). Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats.Juman S, Hashimoto M, Katakura M, Inoue T, Tanabe Y, Arita M, Miki T and Shido O.Nutrients. 5, 1949-1961 (2013). Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH and Murakami M.J. Exp. Med., 210, 1217-1234 (2013) Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.Tajima Y, Ishikawa M, Maekawa K, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Ikeda K, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, and Saito Y.Lipids Health Dis. 12, 68 (2013) Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S and Murakami M.Nat Immunol. 4, 554-63 (2013). The lipid mediator protectin d1 inhibits influenza virus replication and improves severe influenza.Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M and Imai, Y.Cell. 153, 112-25 (2013). Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy.Maekawa K, Hirayama A, Iwata Y, Tajima Y, Nishimaki-Mogami T, Sugawara S, Ueno N, Abe H, Ishikawa M, Murayama M, Matsuzawa Y, Nakanishi H, Ikeda K, Arita M, Taguchi R, Minamino N, Wakabayashi S, Soga T, and Saito Y.J. Mol. Cell Cardiol., 59C, 76-85 (2013). p38MAPK and Rho-dependent kinase are involved in anoikis induced by anicequol or 25-hydroxycholesterol in DLD-1 colon cancer cells.Tanaka AR, Noguchi K, Fukazawa H, Igarashi Y, Arai H, Uehara Y.Biochem. Biophys. Res. Commun., 430,1240-5 (2013).
Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma.Miyata J, Fukunaga K, Iwamoto R, Isobe Y, Niimi K, Takamiya R, Takihara T, Tomomatsu K, Suzuki Y, Oguma T, Sayama K, Arai H, Betsuyaku T, Arita M, Asano K.J Allergy Clin Immunol. 131, 353-60.e1-2. (2013)
「n-3 系脂肪酸の代謝と抗炎症作用についてのメタボローム解析」磯部 洋輔, 岩本 涼, 有田 誠遺伝子医学MOOK, Vol.24 (2013)
「線虫を用いたホスファチジルイノシトールの脂肪酸組成を規定する酵素群の同定」今江 理恵子, 三谷 昌平, 新井 洋由遺伝子医学MOOK, Vol.24 (2013)
「生体膜リン脂質脂肪酸鎖の多様性形成・維持機構とその破綻」河野 望、新井 洋由内分泌・糖尿病・代謝内科, Vol.36, No.6, p479-484 (2013)
「好酸球による炎症とホメオスタシスの制御」松枝 進之介, 磯部 洋輔, 有田 誠炎症と免疫, Vol.21, No.5 (2013)
「細胞内ビタミンE輸送におけるホスファチジルイノシトールリン酸の役割」河野 望、新井 洋由細胞工学, Vol.32, No.10, 1072-1074 (2013)
2012
Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation.Isobe, Y., Kato, T., and Arita, M.Front. Immunol., 3, 270 (2012) Mediator lipidomics in acute inflammation and resolution.Arita, M.J. Biochem., 152, 313-319 (2012)
LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice.Lee, H.C., Inoue, T., Sasaki, J., Kubo, T., Matsuda, S., Nakasaki, Y., Hattori, M., Tanaka, F., Udagawa, O., Kono, N., Itoh, T., Ogiso, H., Taguchi, R., Arita, M., Sasaki, T., and Arai, H.Mol. Biol. Cell, 23, 4689-4700 (2012)
Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans.Lee, H.C., Kubo, T., Kono, N., Kage-Nakadai, E., Gengyo-Ando, K., Mitani, S., Inoue, T., Arai, H.Genes Cells, 17, 748-757 (2012)
Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis.Lee, S., Uchida, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T., and Arai, H.Genes Cells, 17, 728-736 (2012)
Subcellular localization of sphingomyelin revealed by two toxin-based probes in mammalian cells.Yachi, R., Uchida, Y., Balakrishna, B.H., Anderluh, G., Kobayashi, T., Taguchi, T., and Arai, H.Genes Cells, 17, 720-727 (2012)
Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation.Eguchi, K., Manabe, I., Oishi-Tanaka, Y., Ohsugi, M., Kono, N., Ogata, F., Yagi, N., Ohto, U., Kimoto, M., Miyake, K., Tobe, K., Arai, H., Kadowaki, T. and Nagai, R.Cell Metab., 15, 518-533 (2012)
Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during the development in Caenorhabditis elegans.Saitoh, Y., Katane, M., Kawata, T., Maeda, K., Sekine, M., Furuchi, T., Kobuna, H., Sakamoto, T., Inoue, T., Arai, H., Nakagawa, Y.and Homma, H.Mol. Cell. Biol., 32, 1967-1983 (2012)
Vitamin E decreases bone mass by stimulating osteoclast fusion.Fujita, K., Iwasaki, M., Ochi, H., Fukuda, T., Ma, C., Miyamoto, T., Takitani, K., Negishi-Koga, T., Sunamura, S., Kodama, T., Takayanagi, H., Tamai, H., Kato, S., Arai, H., Shinomiya, K., Itoh, H., Okawa, A. and Takeda, S.Nat. Med., 18, 589-594 (2012)
Structural basis of the strict phospholipid binding specificity of the pleckstrin homology domain of human evectin-2.Okazaki, S., Kato, R., Uchida, Y., Taguchi, T., Arai, H. and Wakatsuki, S.Acta. Crystallogr. D. Biol. Crystallogr., 68, 117-123 (2012)
Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid.Isobe, Y., Arita, M., Matsueda, S., Iwamoto, R., Fujihara, T., Nakanishi, H., Taguchi, R., Masuda, K., Sasaki, K., Urabe, D., Inoue, M. and Arai, H.J. Biol. Chem., 287, 10525-10534 (2012)
LYCAT, a homologue of C. elegans acl-8, acl-9 and acl-10, determines the fatty acid composition of phosphatidylinositol in mice.Imae, R., Inoue, T., Nakasaki, Y., Uchida, Y., Ohba, Y., Kono, N., Nakanishi, H., Sasaki, T., Mitani, S. and Arai, H.J. Lipid Res., 53, 335-357 (2012)
Deficiency of cardiolipin synthase causes abnormal mitochondrial function and morphology in germ cells of Caenorhabditis elegans.Sakamoto, T., Inoue, T., Otomo, Y., Yokomori, N., Ohno, M., Arai, H. and Nakagawa, Y.J. Biol. Chem., 287, 4590-4601 (2012)
A novel role for alpha-tocopherol transfer protein (alpha-TTP) in protecting against chloroquine toxicity.Shichiri, M., Kono, N., Shimanaka, Y., Tanito, M., Rotzoll, D.E., Yoshida, Y., Hagihara, Y., Tamai, H. and Arai, H.J. Biol. Chem., 287, 2926-2934 (2012)
Regulation of peroxisomal lipid metabolism by the catalytic activity of the tumor suppressor H-rev107.Uyama, T., Ichi, I., Kono, N., Inoue, A., Tsuboi, K., Jin, X.H., Araki, N., Aoki, J., Arai, H. and Ueda, N.J. Biol. Chem., 287, 2706-2718 (2012)
「脂肪酸の質の違いについて考える」 有田 誠実験医学, Vol. 30, No. 3, p406-411 (2012)
「多価不飽和脂肪酸の代謝と炎症の制御」 磯部 洋輔, 有田 誠実験医学, Vol. 30, No. 3, p423-428 (2012)
「リン脂質の飽和／不飽和バランスと小胞体ストレス応答」河野 望, 新井 洋由 実験医学, Vol. 30, No. 3, p429-434 (2012)
「メタボローム新技術が切り拓くこれからの脂質バイオロジー研究」 有田 誠, 斎藤 嘉朗, 田口 良, 西島 正弘実験医学, Vol. 30, No. 3, p446-454 (2012)
「α-トコフェロール輸送蛋白質とビタミンE欠乏症」河野 望, 新井 洋由内分泌・糖尿病・代謝内科, Vol. 34, No. 3, p254-259 (2012)
「細胞内ホスファチジルセリン(PS)が制御する膜輸送経路」田口 友彦, 新井 洋由生化学, 84, 844-848 (2011)
「ω3/ω6系脂肪酸バランスと炎症の制御」有田 誠Surgery Frontier, Vol. 19, No. 4, p428-430 (2012)
「飽和脂肪酸による炎症・ストレス応答とインスリン抵抗性」河野 望, 新井 洋由Surgery Frontier, Vol. 19, No. 4, p432-435 (2012)
2011
Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.Uchida, Y., Hasegawa, J., Chinnapen, D., Inoue, T., Okazaki, S., Kato, R., Wakatsuki, S., Misaki, R., Koike, M., Uchiyama, Y., Iemura, S., Natsume, T., Kuwahara, R., Nakagawa, T., Nishikawa, K., Mukai, K., Miyoshi, E., Taniguchi, N., Sheff, D., Lencer, W.I., Taguchi, T. and Arai, H.Proc. Natl. Acad. Sci. U. S. A. , 108, 15846-15851 (2011)Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice.Yamada, T., Tani, Y., Nakanishi, H., Taguchi, R., Arita, M. and Arai, H.FASEB J., 25, 561-568 (2011)
LPA-producing enzyme PA-PLA(1)alpha regulates hair follicle development by modulating EGFR signalling.Inoue, A., Arima, N., Ishiguro, J., Prestwich, G.D., Arai, H. and Aoki, J.EMBO J., 30, 4248-4260 (2011)
Autotaxin Regulates Vascular Development via Multiple Lysophosphatidic Acid (LPA) Receptors in Zebrafish.Yukiura, H., Hama, K., Nakanaga, K., Tanaka, M., Asaoka, Y., Okudaira, S., Arima, N., Inoue, A., Hashimoto, T., Arai, H., Kawahara, A., Nishina, H. and Aoki, J.J. Biol. Chem., 286, 43972-43983 (2011)
Total Synthesis and Bioactivities of Two Proposed Structures of Maresin.Sasaki, K., Urabe, D., Arai, H., Arita, M. and Inoue, M.Chem. Asian J., 6, 534-543 (2011)
Prevention of hematogenous metastasis by neutralizing mice and its chimeric anti-Aggrus/podoplanin antibodies.Nakazawa, Y., Takagi, S., Sato, S., Oh-hara, T., Koike, S., Takami, M., Arai, H. and Fujita, N.Cancer Sci., 102, 2051-2057 (2011)
The Novel Metastasis Promoter Merm1/Wbscr22 Enhances Tumor Cell Survival in the Vasculature by Suppressing Zac1/p53-Dependent Apoptosis.Nakazawa, Y., Arai, H. and Fujita, N.Cancer Res., 71, 1146-1155 (2011)
Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.Nakayama, M., Sato, H., Okuda, T., Fujisawa, N., Kono, N., Arai, H., Suzuki, E., Umeda, M., Ishikawa, H.O. and Matsuno, K.PloS One, 6, e22984 (2011)
「エンドソームが構成する膜輸送空間ネットワーク」田口友彦 細胞工学, 30, 1160-1164 (2011)
「炎症の収束における脂質メディエーター代謝系のダイナミックな変化とその機能的役割」有田誠実験医学増刊「慢性炎症」, 29, 46-50 (2011)
「ω３系脂肪酸の代謝と抗炎症作用」有田誠アンチエイジング医学, 7, 22-26 (2011)
「脂質メディエーター (特集 炎症と動脈硬化--基礎・臨床研究の最新動向) -- (動脈硬化の成因・病態生理--炎症とのかかわりを中心に) 」遠藤仁, 有田誠日本臨床 69, 34-38 (2011)
「哺乳動物細胞におけるグリセロリン脂質の生合成とその制御」河野望, 井上 貴雄, 新井 洋由生化学, 83, 462-474 (2011)
「α-TTPノックアウトマウス」河野望, 新井 洋由The Lipid, 22, 4-9 (2011)
「α-TTPの作用機序と疾患」河野望, 新井 洋由ビタミン・ミネラルの科学（朝倉書店）, 194-204
2010
Intracellular PLA1 and Acyltransferase, Which Are Involved in Caenorhabditis elegans Stem Cell Divisions, Determine the sn-1 fatty acyl Chain of Phosphatidylinositol.Imae R., InoueT., Kimura M., Kanamori T., H.Tomioka N., Kage-Nakadai E., Mitani S. and Arai H.Mol. Biol. Cell, 21, 3114-3124 (2010)Multivesicular body formation requires OSBP-related proteins and cholesterol.Kobuna H., Inoue T., Shibata M., Gengyo-Ando M., Yamamoto A., Mitani S. and Arai H.PLoS Genetics, 6, e1001055 (2010)
Decrease in membrane phospholipid unsaturation induces unfolded protein response.Ariyama H., Kono N., Matsuda S., Inoue T. and Arai H.J. Biol. Chem., 221, 87-95 (2010)
ATP-binding cassette transporter A1 (ABCA1) is involved in hepatic α-tocopherol secretion.Shichiri M., Takanezawa Y., Rotzoll D.E., Yoshida Y., Kokubu T., Ueda K., Tamai H. and Arai H.J. Nutr. Biochem., 21, 451-456, (2010)
Resolvins as regulators of the immune system.Seki H., Sasaki T., Ueda T. and Arita M. Scientific World Journal, 10, 818-831 (2010)
The Anti-Inflammatory and Proresolving Mediator Resolvin E1 Protects Mice from Bacterial Pneumonia and Acute Lung Injury.Seki, H., Fukunaga, K., Arita, M., Arai, H., Nakanishi, H., Taguchi, R., Miyasho, T., Takamiya, R., Asano, K., Ishizaka, A., Takeda, J. and Levy, B.D.J. Immunol., 184, 836-843 (2010)
Resolvin E1 receptor activation signals phosphorylation and phagocytosis.Ohira T., Arita M., Omori K., Recchiuti A., Van Dyke TE and Serhan CN. J. Biol. Chem., 285, 3451-3461 (2010)
Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat-Fed Mice.White, P.J., Arita, M., Taguchi, R., Kang, J.X. and Marette, A.Diabetes, 59, 3066-3073 (2010)
Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils.Marcheselli VL., Mukherjee PK., Arita M., Hong S., Antony R., Sheets K., Winkler JW., Petasis NA., Serhan CN. and Bazan NG. Prostaglandins Leukot Essent Fatty Acids, 82, 27-34 (2010)
Lipoxin A4 reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of NF-kB activation.Kure I., Nishiumi S., Nishitani Y., Tanoue T., Ishida T., Mizuno M., Fujita T. Kusumi H., Arita M., Azuma T. and Yoshida M. J Pharmacol Exp Ther., 332, 541-548 (2010)
Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis. Ishida T., Yoshida M., Arita M., Nishitani Y., Nishiumi S., Masuda A., Mizuno S., Takagawa T., Morita Y., Kusumi H., Inokuchi H., Serhan CN., Blumberg RS. and Azuma T.Inflamm Bowel Dis., 16, 87-95 (2010)
Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes.Oushiki D., Kojima H., Terai T., Arita M., Hanaoka K., Urano Y. and Nagano T. J Am Chem Soc., 132, 2795-2801 (2010)
Glucagon Regulates Intracellular Distribution of Adipose Differentiation-Related Protein during Triacylglycerol Accumulation in the Liver.Takahashi K. Sasabe N., Ohshima K., Kitazato K., Kato R., Masuda Y., Tsurumaki M., Obamaa T., Okudairad S., Aoki J., Arai H., Yamaguchi T. and Itabe H.J. Lipid Res., 51, 2571-2580 (2010)
A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1) in human serum samples.Nakamura K., Igarashi K., Ohkawa R., Saiki N., Nagasaki M., Uno K., Hayashi N., Sawada T., Syukuya K., Yokota H., Arai H., Ikeda H., Aoki J. and Yatomi Y.Clin Chim Acta., 411, 1090-1094 (2010)
Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice.Herbas MS., Ueta YY., Ichikawa C., Chiba M., Ishibashi K., Shichiri M., Fukumoto S., Yokoyama N., Takeya M., Xuan X., Arai H. and Suzuki H.Malar J., 9, 101 (2010)
Autotaxin Controls Caudal Diencephalon-Mesencephalon Development in the Chick.Ohuchi, H., Fukui, H., Matsuyo, A., Tomonari, S., Tanaka, M., Arai, H., Noji, S. and Aoki, J.Dev. Dyn., 239, 2647-2658 (2010)
Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex.Nakamura A., Naito M., Arai H. and Fujita N.Biochem. Biophys. Res. Commun., 393, 872-876 (2010)
LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation.Shibata M., Yoshimura K., Tamura H., Ueno T., Nishimura T., Inoue T., Sasaki M., Koike M., Arai H., Kominami E. and Uchiyama Y.Biochem. Biophys. Res. Commun., 393, 274-279 (2010)
α-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice.Herbas M.S., Okazaki M., Terao E., Xuan X., Arai H. and Suzuki H.Am. J. Clin. Nutr., 91, 200-207 (2010)
Aki1 and cohesin function in separase-regulated centriole disengagement.Nakamura A., Arai H. and Fujita N.J. Cell Biol., 91, 200-207 (2010)
Mitotic phosphorylation of Aki1 at Ser(208) by cyclin B1-Cdk1 complex.Nakamura, A., Naito, M., Arai, H. and Fujita, N.Biochem. and Biophys. Res. Commun., 393, 872-876 (2010)
The role of α-tocopherol in hypofunction of activity with aging in α-tocopherol transfer protein knockout mice.Itoh N., Hayakawa M., Habuchi Y., Saito Y., Tsukamoto Y., Cynshi O., Jishage K., Arai H., Niki E. and Yoshida Y.J. Nutr. Biochem., 21, 66-76 (2010)
Two Very Long Chain Fatty Acid Acyl-CoA Synthetase Genes, acs-20 and acs-22, Have Roles in the Cuticle Surface Barrier in Caenorhabditis elegans.Kage-Nakadai E., Kobuna H., Kimura M., Gengyo-Ando K., Inoue T., Arai H. and Mitani S.PLoS One, 4, e8857 (2010)
PAF-AH catalytic subunits modulate the Wnt pathway in developing GABAergic neurons.Livnat, I., Finkelshtein, D., Ghosh, I., Arai, H. and Reiner, O.Front. Cell. Neurosci., 4, pii: 19 (2010)
「脂肪酸代謝と炎症のメタボロミクス」 有田誠 メタボロミクス：その解析技術と臨床・創薬応用研究の最前線, 遺伝子医学MOOK 16, 179-184 (2010)
2009
Functional analysis of GS28, an intra-Golgi SNARE, in C. elegansMaekawa M., Inoue T., Kobuna H., Nishimura T., Gengyo-Ando K., Mitani S., and Arai H.Genes to Cells, 14, 1003-1013 (2009)Intracellular phospholipase A1gamma (iPLA1gamma) is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complexMorikawa RK., Aoki J., Kano F., Murata M., Yamamoto A., Tsujimoto M., and Arai H.J. Biol. Chem., 284, 26620-26630 (2009)
The anti-inflammatory and pro-resolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury.Seki H., Fukunaga K., Arita M., Arai H., Nakanishi H., Taguchi R., Miyasho T., Takamiya R., Asano K., Ishizaka A., Takeda J., and Levy B.D. J Immunol., 184, 836-843 (2009)
Total synthesis and bioactivity of resolvin E2.Ogawa S., Urabe D., Yokokura Y., Arai H., Arita M., and Inoue M. Org. Lett., 11, 3602-3605 (2009)
Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen.Ryu A., Arakane K., Koide C., Arai H., and Nagano T.Biol. Pharm. Bull., 32, 1504-1509 (2009)
The effect of alpha-tocopherol transfer protein gene disruption on Trypanosoma congolense infection in mice.Herbas MS., Thekisoe OM., Inoue N., Xuan X., Arai H., and Suzuki H.Free Rad. Biol. Med., 47, 1408-1413 (2009)
Synthesis and Evaluation of Lysophosphatidylserine Analogs as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidylthreonine and Its 2-Deoxy Derivative.Iwashita M., Makide K., Nonomura T., Misumi Y., Otani Y., Ishida M., Taguchi R., Tsujimoto M., Aoki J., Arai H., and Ohwada T.J. Med. Chem., 52, 5837-63 (2009)
Normal formation of Caenorhabditis elegans intestinal granules requires ABC transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAPL (TAP-like).Kawai H., Tanji T., Hirohisa Shiraishi H., Yamada M., Iijima R., Inoue T., Kezuka Y., Ohashi K., Yoshida Y, Tohyama K., Gengyo-Ando K., Mitani S., Arai H., Ohashi-Kobayashi A., and Maeda M.Mol. Biol. Cell, 20, 2979-2990 (2009)
PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via NF-kB activation.Tanaka H., Hoshikawa Y., Naito M., Noda T., Arai H., Tsuruo T., and Fujita N.Mol. Cancer Res., 7, 557-569 (2009)
The MAP1-LC3 conjugation system is involved in lipid droplet formation.Shibata M., Yoshimura K., Furuya N., Koike M., Ueno T., Komatsu M., Arai H., Tanaka K., Kominami E., and Uchiyama Y.Biochem. Biophys. Res. Commun., 382, 419-423 (2009)
Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolismTakahashi K., Yoshina S., Maekawa M., Itoh W., Inoue T., Shiwaku H., Arai H., Mitani S., and Okazawa H.PLoS One, 4, e4104 (2009)
Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators.Jin Y., Arita M., Zhang Q., Saban DR., Chauhan SK., Chiang N., Serhan CN., and Dana R. Invest Opthalmol Vis Sci., 50, 4743-4752 (2009)
Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1.Seki H., Tani Y., and Arita M. Prostaglandins Other Lipid Mediat., 89, 126-130 (2009)
「細胞内コレステロール輸送の分子機構」 内田安則, 井上貴雄, 新井洋由 コレステロール –基礎から臨床へ–, 14-17, ライフサイエンス出版 (2009)
「コレステロールの細胞膜内動態と脂質ラフト」 内田安則, 井上貴雄, 新井洋由 コレステロール –基礎から臨床へ–, 41-44, ライフサイエンス出版 (2009)
「リゾリン脂質と動脈硬化性疾患」 河野望, 新井洋由The Lipid, 20, 266-276 (2009)
「n-3系多価不飽和脂肪酸の抗炎症作用のメタボロミクス」 有田誠 食品と開発, 45, 21-23 (2009)
「多価不飽和脂肪酸と疾患（炎症性腸疾患）」 有田誠 治療学, 43, 56-60 (2009)
「血小板—内皮細胞相互作用と抗炎症性脂質メディエーター」 谷友香子, 有田誠 血管医学, 10, 143-149 (2009)
2008
Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity.Matsuda S., Inoue T., Lee H.-C., Kono N., Tanaka F., Gengyo-Ando K., Mitani S., and Arai H.Genes to Cells, 13, 879-888 (2008)β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.Kanamori T, Inoue T, Sakamoto T, Gengyo-Ando K, Tsujimoto M, Mitani S, Sawa H, Aoki J, Arai H.EMBO J., 27 1647-57 (2008)
C. elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.Lee H.-C., Inoue T., Imae R., Kono N., Shirae S., Matsuda S., Gengyo-Ando K., Mitani S. and Arai H. Mol. Biol. Cell, 19, 1174-1184 (2008)
Protection against oxidative stress-induced hepatic injury by intracellular type II PAF-acetylhydrolase by metabolism of oxidized phospholipids in vivo. Kono N., Inoue T., Yoshida Y., Sato H., Matsusue T., Itabe H., Niki E., Aoki J. and Arai H. J. Biol. Chem., 283, 1628-1636, (2008)
Elucidating the relationship between DISC1, NDEL1, and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding.Burdick K. E., Kamiya A., Hodgkinson C. A., Lencz T., DeRosse P., Ishizuka K., Elashvili S., Arai H., Goldman D., Sawa A. and Malhotra A. K.Hum. Mol. Genet., 17, 2462-73 (2008)
Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.Nakazawa Y., Sato S., Naito M., Kato Y., Mishina K., Arai H., Tsuruo T., and Fujita N. Blood, 112, 1730-1739 (2008)
Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha.Tachibana K., Anzai N., Ueda C., Katayama T., Yamasaki D., Kirino T., Takahashi R., Ishimoto K., Komori H., Tanaka T., Hamakubo T., Ueda Y., Arai H., Sakai J., Kodama T., Doi T.FEBS Lett., 582, 3884-3888 (2008)
Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation.Nakamura K., Igarashi K., Ide K., Ohkawa R., Okubo S., Yokota H., Masuda A., Oshima N., Takeuchi T., Nangaku M., Okudaira S., Arai H., Ikeda H., Aoki J. and Yatomi Y.Clin. Chim. Acta., 388, 51-58, (2008)
「 オメガ3脂肪酸系メディエーター」 有田 誠 BIO Clinica 23 (1), 56 (2008)「炎症と脂質メディエーター」 新井 洋由 BIO Clinica 23 (1), 16 (2008)
2007
Resolvin E1 and protectin D1 activate inflammation-resolution programmes Schwab, J. M., Chiang, N., Arita, M., and Serhan, C. N. Nature 447, 869-874 (2007)ABCA3 as a lipid transporter in pulmonary surfactant biogenesis.Ban N., Matsumura Y., Sakai H., Takanezawa Y., Sasaki M., Arai H. and Inagaki N.J. Biol. Chem., 282, 9628-9634, (2007)
Identification of a serum component that regulates COX-2 gene expression.Kanayama M., Yamaguchi S., Shibata T., Shibata N., Kobayashi M., Nagai R., Arai H., Takahashi K. and Uchida K. J. Biol. Chem., 282, 24166-24174, (2007)
Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution Campbell, E. L., Louis, N. A., Tomassetti, S. E., Canny, G. O., Arita, M., Serhan, C. N., and Colgan, S. P. Faseb J 21, 3162-3170 (2007)
Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation Arita, M., Ohira, T., Sun, Y. P., Elangovan, S., Chiang, N., and Serhan, C. N.J Immunol 178, 3912-3917 (2007)
Protection of cerebellar granule cells by tocopherol and tocotrienol against methylmercury toxicity. Shichiri M., Takanezawa Y., Uchida K., Tamai H. and Arai H.Brain Res., 1182, 106-115, (2007)
Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice.Hama K., Aoki J., Inoue A., Endo T., Amano T., Motoki R., Kanai M., Ye X., Chun J., Matsuki N., Suzuki H., Shibasaki M. and Arai H.Biol. Reprod. 77, 954-959, (2007)
Type I platelet-activating factor acetylhydrolase catalytic subunit overexpression induces pleiomorphic nuclei and centrosome amplification.Yamaguchi N., Koizumi H., Aoki J., Natori Y., Nishikawa K., Natori Y., Takanezawa Y. and Arai H.Genes to Cells, 12, 1153-1161, (2007)
Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4.Morita S.Y., Kobayashi A., Takanezawa Y., Kioka N., Handa T., Arai H., Matsuo M. and Ueda K.Hepatology, 46, 188-199, (2007)
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD). Mori K., Kitayama J., Aoki J., Kishi Y., Shida D., Yamashita H., Arai H. and Nagawa H.Virchows Arch., 451, 47-56, (2007)
Galactosamine-induced acute liver injury in rats reduces α-tocopherol-transfer protein (α-TTP) mRNA and protein levels in the liver.Takenaka A., Kita A., Ikeya M., Arai H. and Igarashi K.J. Nutr. Sci. Vitaminol. 53, 366-371, (2007)
Serum lysophospholipase D/autotoxin may be a new nutritional assessment marker: study on prostate canser patients.Nakamura K., Takeuchi T., Ohkawa R., Okubo S., Yokota H., Tozuka M., Aoki J., Arai H., Ikeda H., Oshima N., Kitamura T. and Yatomi Y.Ann. Clin. Biochem., 44, 549-556, (2007)
Lysophosphatidic acid protection against apoptosis in the human pre-B-cell line Nalm-6.Satoh Y ., Ohkawa R., Nakamura K., Higashi K., Kaneko M., Yokota H., Aoki J., Arai H., Yuasa Y. and Yatomi Y. Eur. J. Haematol., 78, 510-517, (2007)
Phospholipase A1 assays using a radio-labeled substrate and mass spectrometry.Morikawa R., Tsujimoto M., Arai H. and Aoki J. Methods in Enzymol., 434, 1-13, (2007)
Type F scavenger receptor SREC-I interact with protein phosphatase 1a in L cells to induce neurite-like outgrowth.Ishii J., Adachi H., Shibata N., Arai H. and Tsujimoto M. Biochem. Biophys. Res. Commun., 360, 269-274, (2007)
Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.Watanabe N., Ikeda H., Nakamura K., Ohkawa R., Kume Y., Aoki J., Hama K., Okudaira S., M., Tanaka Yanase M., Nagashima K., Tomiya T., Arai M., Inoue Y., Tejima K., Nishikawa T., Arai H., Omata M., Fujiwara K. and Yatomi Y. J. Clin. Gastroenterol., 41, 616-623, (2007)
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.Tokumura A., Kume T., Fukuzawa K., Tahara M., Tasaka K., Aoki J., Arai H., Yasuda K. and Kanzaki H. Life Sci., 80, 1641-169, (2007)
Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development.Ohuchi H., Hayashibaral Y., Matsuda H., Onoi M., Mitsumori M., Tanaka M., Aoki J., Arai H. and Noji S. Dev. Dyn., 236, 1134-1143, (2007)
Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia.Umemura K., Kato I., Hirashima Y., Ishii Y., Inoue T., Aoki J., Kono N., Oya T. , Hayashi N., Hamada H., Endo S., Oda M., Arai H., Kinouchi H. and Hiraga K.Stroke, 38, 1063-108, (2007)
Measurement of lysophospholipase D/autotaxin activity in human serum samples. Nakamura K., Ohkawa R., Okubo S., Tozuka M., Okada M., Aoki S., Aoki J., Arai H., Ikeda H. and Yatomi Y.Clin. Biochem., 40, 274-247, (2007)
Strucuture and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family.Aoki J., Inoue A., Makide K., Saiki N. and Arai H.Biochimie, 89, 197-204, (2007)
「 高度不飽和脂肪酸由来の抗炎症性メディエーター」 有田 誠 細胞工学 Vol. 26 No.11 (2007)
「細胞内コレステロール調節機構」 井上貴雄・新井洋由 細胞 Vol. 39 No.10 423-426 (2007)
「 オメガ3脂肪酸から産生される抗炎症性脂質メディエーター」 有田 誠 ファルマシア Vol. 43 No.6 (2007)
「 炎症を緩和するケミカルメディエーター オメガ3脂肪酸に由来するレゾルビンとプロテクチン」 有田 誠・Charles N. Serhan 蛋白質 核酸 酵素 Vol. 52 No.4 (2007)
2006
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic Acid.Kishi Y., Okudaira S., Tanaka M., Hama K., Shida D., Kitayama J., Yamori T., Aoki J., Fujimaki T. and Arai H. J. Biol. Chem., 281, 17492–17500, (2006)Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.Tanaka M., Okudaira S., Kishi Y., Ohkawa R., Iseki S., Ota M., Noji S., Yatomi Y., Aoki J. and Arai H. J. Biol. Chem., 281, 25822-25830, (2006)
Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.Shibata N., Jishage K., Arita M., Watanabe M., Kawase Y., Nishikawa K., Natori Y., Inoue H., Shimano H., Yamada N., Tsujimoto M. and Arai H. FASEB J., 20, 2642-2644, (2006)
Disturbance of DISC1-NUDEL protein interaction, an essential component for neurite outgrowth, by genetic variations of DISC1.Kamiya A., Tomoda T., Chang J., Takaki M., Zhan C., Cascio M. B., Elashvili1 S., Koizumi H., Takanezawa Y., Robert F. D., Arai H. and Sawa A. Hum. Mol. Genet., 15, 3313-3323, (2006)
Cyclic phosphatidic acid is produced by autotaxin in blood. Tsuda S., Okudaira S., Moriya-Ito K., Tanaka M., Aoki J., Arai H., Murakami K. and Kobayashi T. J. Biol. Chem., 281, 26081-26088, (2006)
Analysis of PPAR alpha function in human kidney cell line using siRNA.Tachibana K., Anzai N., Ueda C., Katayama T., Kirino T., Takahashi R., Yamasaki D., Ishimoto K., Tanaka T., Hamakubo T., Ueda Y., Arai H., Sakai J., Kodama T. and Doi T. Nucleic Acids Symp. Ser., 50, 257-258, (2006)
ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. MasudaY., Itabe H., Odaki M., Hama K., Fujimoto Y., Mori M., Sasabe N., Aoki J., Arai H. and Takano T.J. Lipid Res., 47, 87-98, (2006)
Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1.Kobayashi A., Takanezawa Y., Hirata T., Shimizu Y., Misasa K., Kioka N., Arai H., Ueda K. and Matsuo M. J. Lipid Res., 47, 1791-1802, (2006)
Lysophosphatidic receptor, LPA3 is positively and negatively regulated by progesterone and estrogen in the mouse uterus.Hama K., Aoki J., Bandoh K., Inoue A., Endo T., Amano T., Suzuki H. and Arai H. Life Sci., 79, 1736-1740, (2006)
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.Okazaki H., Tazoe F., Okazaki S., Isoo N., Tsukamoto K., Sekiya M., Yahagi N., Iizuka Y., Ohashi K., Kitamine T., Tozawa R., Inaba T., Yagyu H., Okazaki M., Shimano H., Shibata N., Arai H., Nagai R., Kadowaki T., Osuga J. and Ishibashi S. J Lipid Res., 47, 1950-1958, (2006)
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective Agonists.Qian L., Xu., Simper T., Jiang G., Aoki J., Umezu-Goto M., Arai H., Yu S., Mills G., Tsukahara N., Makarova Y., Fujiwara G., Tigyi G. and Prestwich D.Chem. Med. Chem, 1, 376-383, (2006)
A novel sulfotransferase abundantly expressed in the dauer larvae of Caenorhabditis elegans.Hattori K., Inoue M., Inoue T., Arai H. and Tamura H. J. Biochem. (Tokyo), 139, 55-62, (2006)
Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer. Yamashita H., Kitayama J., Shida D., Ishikawa M., Hama K., Aoki J., Arai H. and Nagawa H. J. Surg. Oncol., 93, 30-35, (2006)
Activation of MAP kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Watanabe N., Zmijewski J. W., Takabe W., Umezu-Goto, M. LeGoffe C., Sekine A., Landar A, Watanabe A., Aoki J., Arai H., Kodama T., Murphy M. P., Kalyanaraman R., Darley-Usmar V. M. and Noguchi N. Am. J. Pathol., 168, 1737-1748, (2006)
Triglyceride hydrolase-2, a novel paralogue of triglyceride hydrolase, is regulated by nutritional conditions in adipose tissue.Okazaki H., Osuga J., Igarashi M., Tajima M., Nishi M., Sekiya M., Okazaki S., Yahagi N., Tsukamoto K., Amemiya-Kudo M., Matsuzaka T., Shimano H., Yamada N., Aoki J., Morikawa R., Takanezawa Y., Arai H., Nagai R., Kadowaki T. and Ishibashi S. Diabetes, 55, 2091-2097, (2006)
Phospholipase A1: structure, distribution and function Inoue A. and Aoki J. Future Lipidology 1, 687-700 (2006)
2005
Regulation of SR-BI protein level by its associated protein CLAMP/PDZKI through phosphorylation.Nakamura T., Nishimoto T., Shibata N., Feng D., Ikemoto M., Isoo N., Tsukamoto K. and Arai H. Proc. Natl. Acad. Sci. USA, 102, 13404-13409, (2005) Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase (NPP) family.Sakagami H., Aoki J., Natori Y., Nishikawa K., Kakehi Y., Natori Y. and Arai H. J. Biol. Chem., 280, 23084-23093, (2005)
LPA3-mediated lysophosphatidic acid signalling in implantation and embryo spacing. Ye X., Hama K., Contos J. J. A., Anliker B., Inoue A., Skinner M. K., Suzuki H., Amano T., Kennedy G., Arai H., Aoki J. and Chun J. Nature, 435, 104-108, (2005)
Neuronal expression and neuritogenic action of group X secreted phospholipase A2.Masuda S., Murakami M., Takanezawa Y., Aoki J., Arai H., Ishikawa Y., Ishii T., Arioka M. and Kudo I. J. Biol. Chem., 280, 23203-23214, (2005)
Group VIB Ca2+-independent phospholipase A2 (iPLA2γ) promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipase A2s.Murakami M., Masuda S., Ueda-Semmyo K., Yoda E., Kuwata, H. Takanezawa Y., Aoki J., Arai H., Sumimoto H., Ishikawa Y., Ishii T., Nakatani Y. and Kudo I. J. Biol. Chem., 280, 14028-14041, (2005)
Discovery of high-affinity LPA3 receptor agonists; Structure-activity relationships of fluorinated lysophosphatidic acid analogues. Xu Y., Aoki J., Shimizu K., Goto-Umezu M., Hama K., Takanezawa Y., Yu S., Mills G. B., Arai H., Qian L. and Prestwich G. D. J. Med. Chem., 48, 3319-3327, (2005)
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells. Baumforth K. R., Flavell J. R., Reynolds G. M., Davies G., Pettit T. R., Wei W., Morgan S., Stankovic T., Kishi Y., Arai H., Nowakova M., Pratt G., Aoki J., Wakelam M. J., Young L. S. and Murray P. G. Blood, 106, 2138-2146, (2005)
Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer.Yamashita H., Kitayama J., Shida D., Ishikawa M., Hama K., Aoki J., Arai H. and Nagawa H. J. Surg. Oncol., 93, 30-35, (2005)
Structure-activity relationships of fluorinated lysophosphatidic acid analogues.Xu Y., Aoki J., Shimizu K., Umezu-Goto M., Hama K., Takanezawa Y., Yu S., Mills G. B., Arai H., Qian L. and Prestwich G. D. J. Med. Chem., 48, 3319-3327, (2005)
Cholesterol biosynthesis inhibition by 25-hydoxycholesterol is independent of OSBP.Nishimura T., Inoue T., Shibata N., Sekine A., Noguchi N. and Arai H. Genes to Cells, 10, 793-780, (2005)
Vitamin E is essential for mouse placentation but not for embryonic development itself. Jishage K., Tachibe T., Ito T., Shibata N., Suzuki S., Mori T., Hani T., Arai H. and Suzuki H. Biol. Reprod., 73, 983-987, (2005)
MBR-1, a novel helix-turn-helix transcription factor, is required for pruning of excessive neurites in Caenorhabditis elegans.Kage E., Hayashi Y., Takeuchi H., Hirotsu T., Kunitomo H., Inoue T., Arai H., Iino Y. and Kubo T.Current Biology, 15, 1554-1559, (2005)
Induction of autotaxin by the Epsein-Barr virus promotes the growth and survival of Hodgkin’ lymphoma cells. Baumforth K. R. N., Flavell J. R., Reynolds G. M., Davies G., Pettit T. R., Wei W., Morgan S., Stankovic T., Kishi Y., Arai H., Nowakova M., Pratt G., Aoki J., Wakelam M. J. O., Young L. S. and Murra P. G . Blood, 106, 2138-2146, (2005)
「コレステロールホメオスタシスと動脈硬化」 井上貴雄、新井洋由 内分泌・糖尿病科, 21, 410-416 (2005)
「線虫遺伝学とメタボローム解析による脂質関連遺伝子の機能解析」 井上貴雄、高根沢康一、新井洋由 実験医学, 23, 977-985 (2005)
「 脂質メディエーターの細胞膜受容体」 青木淳賢、濱弘太郎 わかる実験医学シリーズ：脂質生物学がわかる 59-67 (2004)
「脂質生物学の現状と展望」 新井洋由 実験医学 23, 812-821 (2005)
「リゾリン脂質性メディエーターの産生機構」 青木淳賢、後藤牧子 実験医学 23, 902-910 (2005)
「LPA受容体LPA3と着床」 青木淳賢、新井洋由 医学のあゆみ 215, 758-759 (2005)
2004
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.Hama K., Aoki J., Fukaya M., Kishi Y., Sakai T., Suzuki R., Ohta H., Yamori T., Watanabe M., Chun J. and Arai H. J. Biol. Chem., 279, 17634-17639, (2004) Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in C. elegans.Inoue T., Aoki J., Sugimoto A., Suzuki Y., Yamamoto M., Tsujimoto M., Inoue K. and Arai H. Proc. Natl. Acad. Sci. USA, 101, 13233-13238, (2004)
54 Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.Tamura Y., Osuga J., Adachi H., Tozawa R., Takanezawa Y., Ohashi K., Yahagi N., Sekiya M., Okazaki H., Tomita S., Iizuka Y., Koizumi H., Inaba T., Yagyu H., Kamada N., Suzuki H., Shimano H., Kadowaki T., Tsujimoto M., Arai H., Yamada N. and Ishibashi S. J. Biol. Chem., 279, 30938-30944, (2004)
SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth in mouse fibroblastic L cells. Shibata M., Ishii J., Koizumi H., Shibata N., Dohmae N., Takio K., Adachi H., Tsujimoto M. and Arai H. J. Biol. Chem., 279, 40084-40090, (2004)
Anti-apoptotic actions of the platelet activating factor acetylhydrolase I catalytic subunit. Bonin F., Ryan S. D., Migahed L., Mo F., Lallier J., Franks D. J., Arai H. and Bennett S. A. L. J. Biol. Chem., 279, 52425-52436, (2004)
Dual regulation of migration by lysophosphatidic acid in human gastric cancer cells.Shida D., Kitayama J., Yamaguchi H., Hama K., Aoki J., Arai H., Yamashita H., Moria K., Sako A., Konishi T., Watanabe T., Sakai T., Suzuki R., Ohta H., Takuwa Y. and Nagawa H. Exp. Cell Res., 30, 168-78, (2004)
Mechanisms of lysophosphatidic acid production.Aoki J.Semin. Cell Dev. Biol. 15, 477-489 (2004)
Alkyl lysoposphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agoninst for LPA receptors. Xu Y., Tanaka M., Arai H., Aoki J. and Prestowich G. D.Biorg. Medicinal Chem. Lett., 14, 5323-5328, (2004)
Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer. Shida D., Watanabe T., Aoki J., Hama K., Kitayama J., Sonoda H., Kishi Y., Yamaguchi H., Sasaki S., Sako A., Konishi T., Arai H. and Nagawa H. Lab. Invest., 84, 1352-1362, (2004)
Overexpression of lysophosphatidic acid receptor-2 (LPA2) in human invasive ductal carcinoma.Kitayama J., Shida D., Sako A., Ishikawa M., Hama K., Aoki J., Arai H. and Nagawa H. Breast Can, Res., 6, R640-R646, (2004)
Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma.Tanaka M., Kishi Y., Takanezawa Y., Kakehi Y., Aoki J. and Arai H. FEBS Lett., 571, 197-204, (2004)
Extracting specific conformations using a carbohydrate scaffold: discovery of new subtype-selective LPA receptor agonists and antagonist.Tamaruya Y., Suzuki M., Kamura G., Kanai M., Hama K., Shimizu K., Aoki J., Arai H. and Shibasaki M. Ang. Chem. Int., 43, 2834-2837, (2004)
Expression of NUDEL in manchette and its implication in spermatogenesis. Yamaguchi N., Takanezawa Y., Koizumi H., Umezu-Goto M., Aoki J. and Arai H. FEBS Lett., 566, 71-76, (2004)
「細胞内脂質輸送タンパク質」 井上貴雄、新井洋由 生化学, 76, 553-561 (2004)
「 オキシステロール結合蛋白質（oxysterol-binding protein; OSBP）」 井上貴雄、新井洋由The Lipid, 15, 53-58 (2004)
2003
Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1α and mPA-PLA1β.Hiramatsu T., Sonoda H., Takanezawa Y., Morikawa R., Ishida M., Kasahara K., Sanai Y., Taguchi R., Aoki J. and Arai H. J. Biol. Chem., 278, 49, 49438-49447, (2003) Targeted disruption of intracellular type I platelet-activating factor acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis. Koizumi H., Yamaguchi N., Hattori M., Ishikawa T., Aoki J., Taketo M., Inoue K. and Arai H. J. Biol. Chem., 278, 12489-12494, (2003)
Fibrates downregulate hepatic scavenger receptor class B type I (SR-BI) protein expression in mice. Mardones P., Pilon A., Bouly M., Duran D., Nishimoto T., Arai H., Kozarsky F., Altayo M., Miquel J. F., Luc G., Clavey V., Staels B. and Rigotti A. J. Biol. Chem., 278, 7884-7890, (2003)
LIS1 missense mutations: Variable phenotypes result from unpredictable alterations in biochemical and cellular properties. Caspi M., Coquelle F. M., Koifman C., Levy T., Arai H., Aoki J., Mey R J. and Reiner O. J. Biol. Chem., 278, 38740-38748, (2003)
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARg agonist.McIntyre T. M., Pontsler A. V., Silva A. R., Hilaire A., Xu Y., Hinshaw J. C., Zimmerman G. A., Hama K., Aoki J., Arai H. and Prestwich G. D. Proc. Natl. Acad. Sci. USA, 100, 131-136, (2003)
Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hepertensive rats.Tsunoda M., Tenhunen J., Tilgmann C., Arai H. and Imai K. Hypertens., Res. 26, 11, 923-927, (2003)
Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid.Qian L., Xu Y., Arai H., J Aoki., Mclntyre T. M. and Prestwich G. D. Org. Lett., 5, 24, 4685-4688, (2003)
pH-Dependent fluctuation of α-tocopherol transfer protein (α-TTP) between hepatic cytosol and late endosomes.Horiguchi M., Arita M., Kaempf-Rotzoll D. E, Tsujimoto M., Inoue K. and Arai H. Genes to Cells, 8, 789-800, (2003)
Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo. Yoshida K., Nishida W., Hayashi K., Ohkawa Y., Ogawa A., Aoki J., Arai H. and Sobue K. Circulation, 108, 1746-1752, (2003)
Vitamin E and transfer proteins. Kaempf-Rotzoll D. E., Traber M. G. and Arai H. Current Opinion in Lipidology (review), 14, 249-254, (2003)
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site.Gijsbers R., Aoki J., Arai H. and Bollen M. FEBS Lett., 538, 60-64, (2003)
Human placental trophoblast cells express α-tocopherol transfer protein.Kaempf-Rotzoll D. E., Horiguchi M., Hashiguchi K., Aoki J., Tamai H., Linderkamp O. and Arai H. Placenta, 24, 439-444, (2003)
Elimination of the vertabrate E. coli Ras-like protein homologue leads to cell cycle arrest at G1 phase and apoptosis. Gohda J., Nomura Y., Suzuki H., Arai H., Akiyama T. and Inoue J. Oncogene, 22, 1340-1348, (2003)