Research
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Research 1 : Advanced gene editing & cell therapy
◾RAD51-mediated stabilization of RNA/DNA hybrids (R-loops) to enhance CRISPR-Cas9 activity
◾Mechanistic study on Cas9 dissociation and R-loop resolution for improved DNA repair outcomes
◾Precise gene insertion and deletion strategies using optimized donor template systems
◾Development of high-efficiency gene editing platforms for Embryonic Stem Cells
◾Enhancement of Homologous Recombination (HR) efficiency for precise genome engineering
◾Application of enhanced CRISPR tools for next-generation Gene and Cell Therapy
Research 2 : Chromosome dynamics & cohesinopathy
◾Cohesin-mediated DNA loop extrusion and 3D genome organization during the interphase
◾Spatial coordination between Cohesin and Condensin for precise chromosome compaction during the prophase-metaphase transition
◾Regulation of embryonic stem cell fate through Cohesin-dependent chromatin architecture and cell cycle control
◾Molecular basis of tissue-specific defects such as skin hypopigmentation in Cohesin-related disorders
◾Mechanism of Condensin hyperloading triggered by elevated RB expression in Cohesin deficient cells
◾Functions of meiosis cohesin factor during mitotic cell cycle
Research 3 : Precision oncology & Next-generation drug screening
◾Identification of key tumor-promoting genes through clustering analysis of DNA repair, mTOR, and EGFR pathways
◾Development of CRISPR-Cas9 dual-gRNA expression systems for simultaneous dual-targeting of oncogenic drivers
◾Exploration of synthetic lethality mechanisms to maximize Triple-Negative Breast Cancer (TNBC) growth inhibition
◾Mechanistic studies on drug-gene interactions within the PI3K/AKT/mTOR signaling axis using dual-vector systems
◾High-throughput screening (HTS) of next-generation therapeutic candidates including Alpelisib, Inavolisib, and Everolimus
◾Establishment of high-efficiency precise genome editing platforms for tumor-specific gene suppression and drug efficacy evaluation
Funding sources
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