Genome Engineering Lab
Advanced Genome Editing – Genomic Integrity – ESC Models – Gene Therapy & Cancer Therapeutics
EH Choi research group at KNUT
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Research Overview
Advanced genome editing and stem cell models hold great promise in modern molecular medicine. However, maintaining genomic integrity during precise editing and translating these molecular tools into safe clinical applications remain significant challenges. Our laboratory utilizes advanced genome editing technologies and ESC models to investigate the fundamental mechanisms of genomic stability and to develop innovative strategies for gene therapy and cancer therapeutics.
Recent Publications
Recent applications, future perspectives, and limitations of the CRISPR-Cas system
Park, et al., Molecular Therapy Nucleic Acids. 2025
Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells
Choi, et al., Scientific Reports. 2025
Biallelic BRF2 mutations disrupt redox homeostasis as etiological factors in syndromic immunodeficiency and developmental disorders
Yoon, et al., Molecular Therapy. 2025
Identification of YAP regulators through high-throughput screening and NanoBiT-based validation-drug repositioning for cancer therapy
Lim, et al., Anim. Cell. Syst. 2025
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