Epigenetics of Cardiometabolic Diseases
Our research focuses on understanding how stress, infections, and environmental cues induce long-lasting epigenetic and metabolic reprogramming that contributes to cardiometabolic diseases. We investigate the molecular mechanisms linking inflammation, immune cell plasticity, chromatin dynamics, and metabolic dysfunction using integrative approaches in molecular biology, immunology, epigenomics, and computational biology.
The lab is particularly interested in stress-induced epigenetic memory and its role in accelerating atherosclerosis, metabolic disorders, and cardiovascular complications
Model Summarizing Loss of HMGN on Adipocyte Browning
Network Pharmacology and Drug Discovery
Our lab also employs network pharmacology, molecular docking, and computational drug discovery approaches to investigate the therapeutic potential of bioactive compounds derived from medicinal plants. By integrating systems biology, protein–protein interaction networks, pathway enrichment analysis, molecular docking, and in silico pharmacokinetic predictions, we aim to identify key molecular targets and signaling pathways associated with diabetes, hypertension, and atherosclerosis. These approaches enable us to understand multi-target mechanisms of phytochemicals and prioritize candidate compounds with potential cardiometabolic protective effects for further experimental validation. Through this integrative strategy, we seek to bridge traditional medicinal knowledge with modern computational biology and translational therapeutics.
Ms. Alka Singh
(M.Sc Biotech IV semester research student)