Drive Ahead! is a driving game where your goal is not to cross the finish line or get as far as you can. Instead, your sole aim is to destroy your opponents ... before they destroy you. To do that you'll have to try to knock the other driver in the head.
Drive Ahead! has plenty of variety in terms of arenas, but that's not all. The game also includes more than 30 different vehicles, ranging from small go-karts to trucks carrying toxic waste. Besides that, you can also customize your character's helmet.
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Drive Ahead! is an original and fun game which also has great graphics. The best part, though, is that there's a multiplayer mode where you can face off against a friend on the same Android, each on a different side of the device. Things are bound to get crazy!
Most of the time, it's a fun game to play, however, there are a lot of ads. Pretty much after every time a match ends, there's an ad, which is super annoying. Also, the game is really frustrating at t...
Uptodown is a multi-platform app store specialized in Android. Our goal is to provide free and open access to a large catalog of apps without restrictions, while providing a legal distribution platform accessible from any browser, and also through its official native app.
No additional viral drug resistance to doravirine was observed in study
participants between Week 48 and Week 96, while two study participants
in the EFV/FTC/TDF group developed viral drug resistance to EFV.
DRIVE-AHEAD is a Phase 3 multicenter, double-blind, randomized clinical
trial in which 728 participants with no antiretroviral treatment history
were randomized and received at least one dose of either DELSTRIGO or
efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV 600 mg/FTC
200 mg/TDF 300 mg) once daily. The primary endpoint of the clinical
trial was the proportion of participants with HIV-1 RNA copies of less
than 50 copies/mL at Week 48. The primary safety endpoint was the
proportion of participants with neuropsychiatric adverse events through
Week 48 in the following pre-specified categories: dizziness, sleep
disorders and disturbances and the inability to think clearly or
concentrate (altered sensorium). The trial consists of a 96-week
double-blind treatment period (base study) and an open label extension
after participants complete the base study. Secondary endpoints include
efficacy at Week 96, an evaluation of the effects of DELSTRIGO and
EFV/FTC/TDF on fasting serum lipids, change from baseline in CD4+ T-cell
count and evaluation of safety and tolerability. For further information
regarding DRIVE-AHEAD please visit www.clinicaltrials.gov
clinical trial registry number NCT02403674.
All patients with HIV-1 should be tested for the presence of HBV before
initiating antiretroviral therapy. Severe acute exacerbations of HBV
have been reported in patients who are coinfected with HIV-1 and HBV and
have discontinued products containing 3TC or TDF, which are components
of DELSTRIGO. Patients coinfected with HIV-1 and HBV who discontinue
DELSTRIGO should be monitored with both clinical and laboratory
follow-up for at least several months after stopping DELSTRIGO. If
appropriate, initiation of anti-HBV therapy may be warranted.
Renal impairment, including cases of acute renal failure and Fanconi
syndrome, have been reported with the use of TDF. DELSTRIGO should be
avoided with concurrent or recent use of a nephrotoxic agent, as cases
of acute renal failure after initiation of high-dose or multiple NSAIDs
have been reported in patients with risk factors for renal dysfunction
who appeared stable on TDF.
Prior to or when initiating DELSTRIGO, and during treatment, assess
serum creatinine, estimated creatinine clearance, urine glucose and
urine protein in all patients. In patients with chronic kidney disease,
also assess serum phosphorus. Discontinue DELSTRIGO in patients who
develop clinically significant decreases in renal function or evidence
of Fanconi syndrome. Discontinue DELSTRIGO if estimated creatinine
clearance declines below 50 mL/min.
In clinical trials in HIV-1 infected adults, TDF was associated with
slightly greater decreases in bone mineral density (BMD) and increases
in biochemical markers of bone metabolism. Serum parathyroid hormone
levels and 1,25 vitamin D levels were also higher. Cases of osteomalacia
associated with proximal renal tubulopathy have been reported with the
use of TDF.
Immune reconstitution syndrome can occur, including the occurrence of
autoimmune disorders with variable time to onset, which may necessitate
further evaluation and treatment. Because DELSTRIGO is a complete
regimen, co-administration with other antiretroviral medications for the
treatment of HIV-1 infection is not recommended.
There is a pregnancy exposure registry that monitors pregnancy outcomes
in individuals exposed to DELSTRIGO during pregnancy. Healthcare
providers are encouraged to register patients by calling the
Antiretroviral Pregnancy Registry at 1-800-258-4263. Mothers infected
with HIV-1 should be instructed not to breastfeed if they are receiving
DELSTRIGO due to the potential for HIV-1 transmission. Because DELSTRIGO
is a fixed-dose combination tablet and the components cannot be altered,
it is not recommended in patients with estimated creatinine clearance
less than 50 mL/min.
There is a pregnancy exposure registry that monitors pregnancy outcomes
in individuals exposed to PIFELTRO during pregnancy. Healthcare
providers are encouraged to register patients by calling the
Antiretroviral Pregnancy Registry at 1-800-258-4263. Mothers infected
with HIV-1 should be instructed not to breastfeed if they are receiving
PIFELTRO due to the potential for HIV transmission.
For more than 30 years, Merck has been committed to scientific research
and discovery in HIV and we continue to be driven by the conviction that
more medical advances are still to come. Our focus is on pursuing
research that addresses unmet medical needs and helps people living with
HIV and their communities. We remain committed to working hand-in-hand
with our partners in the global HIV community to address the complex
challenges to continuing progress.
A full passenger compartment cleaning with food-safe biodegradable Vital Oxide is performed, and hand sanitizer is always available. Our drivers wear masks for the duration of your journey unless the Passenger Barrier is requested.
The hallmark of the American West is the cattle drive, and the prime mover of that immense undertaking is the cowboy. Heat, thirst, hostiles, competing drives, stampedes, and other unknowns loom ahead. For the younger ones, ignorance is bliss; this veteran knows it for what it is.
(West Trenton, N.J.) -- Reflecting the Delaware River Basin Commission's (DRBC) commitment to communities throughout our shared waters, the agency is kicking off a distributed food drive benefiting food pantries in several upper Delaware River Basin communities.
Donations are being collected through June 4 and will be presented to the Narrowsburg Ecumenical Food Pantry, the Wayne County Food Pantry Program, and the Sullivan County Federation for the Homeless at the DRBC's second-quarter business meeting in Narrowsburg, N.Y., on June 5.
Collection points also reflect the partnership at DRBC, with an array of nonprofits, local businesses, and government offices in New York and Pennsylvania generously hosting drop-off locations. DRBC staff will also be on hand at the Barryville Farmers Market for ShadFest on May 18 to collect donations and share information about the agency's upcoming programs and meetings.
"Interstate collaboration is at the heart of DRBC's mission to manage and improve the Basin's water resources for the benefit of over 14 million people," DRBC Deputy Executive Director Kristen Bowman Kavanagh said. "While we focus on the Delaware River's water resources every day, our agency culture of caring for our communities runs deep."
The DRBC's second-quarter business meeting will be held at the Tusten Theatre, 210 Bridge St, Narrowsburg, NY, beginning at 10:30 a.m. The meeting is open to the public and additional activities will follow the Commission's official business, including an open public comment session and a film screening.
The DRBC is a federal/interstate government agency created in 1961 by concurrent compact legislation, marking the first time that the federal government and a group of states joined together as equal partners in a river basin planning, development and regulatory agency. The five Commission members are the governors of the Basin states (Delaware, New Jersey, New York and Pennsylvania) and the commander of the U.S. Army Corps of Engineers' North Atlantic Division, who represents the federal government.
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