Multicomponent Reactions (MCRs) 

Notwithstanding significant advancements made in the previous several decades in organic synthesis for the stereocontrolled creation of natural products and medicinal compounds, the creation of risk-free synthetic methods that provide large yields while concentrating on sustainability and efficiency is still highly challenging. The traditional step-by-step approaches often included extracting the product intermediates via sophisticated purification processes, resulting in a significant amount of waste production and violating the fundamentals of green chemistry. In light of this, multiple bond-forming transformations (MBFTs), which produce multiple bonds in a single step, are becoming increasingly significant in all areas of organic synthesis, particularly in the synthesis of heterocycles. Among various MBFTs, multicomponent reactions (MCRs) have appeared as the most versatile approach and have tremendously grown in organic synthesis in recent years. In general, multicomponent reactions (MCRs) are characterized as those reactions involving more than two reagents or starting molecules that are operated through a single synthetic operation to produce the desired product which comprises most of the employed atoms of the starting reagents. 

Considering the great significance of multicomponent reactions, our group is mainly focusing on the synthesis of diverse complex heterocyclic compounds that are widely present in natural products and have remarkable biological properties. The synergic combination of three or more pharmacophore units in a single hybrid molecule through multicomponent reaction is another interest of our group.