Synthesis of Complex Heterocyclic Compounds

Heterocyclic compounds comprise a huge family of the indispensable class of organic molecules that are ubiquitously recognized in a variety of drugs available on the market and/or in clinical trials, and many more medicinal candidates used in the drug discovery process. According to literature reports, it was revealed that almost 80% of small molecule drugs approved by the FDA contain at least one heterocycle as the key fragment in their structure. Apart from these, heterocyclic compounds are widely spread in nature, play a unique role in nature, and are considered the essential building blocks for most of the natural biological processes which are fundamental to life. Notwithstanding these, heterocyclic compounds are ubiquitously known for their key manifestation in numerous marine alkaloids, and pharmaceutically active natural products, which are very substantial to human and animal health. Literature reports revealed that natural products with heterocyclic cores are the main source of a huge number of medications used by worldwide today. 

Despite these, the inclusion of a heterocycle either as a single molecule or a substituted molecule can modulate some of the properties of the drug molecules for instance, they offered a tool for the modification of potency and selectivity, lipophilicity, aqueous solubility, and hydrogen bonding interaction of the molecule. For a long time, the chemical community has focused on comprehending and implementing the features demonstrated by both natural and synthetic molecules. Owing to the remarkable properties associated with their structure, heterocyclic compounds have fulfilled some of the criteria for this purpose, which are now in routine usage in modern society. From ancient cave paintings to present times, humanity has taken benefit from the existence of colors in nature. Consequently, a variety of natural and synthetic organic pigments or dyes containing heterocycles as the core moiety have been devised which have broad applications in textile, food, cosmetics, ink, paint, rubber, dye-sensitized solar cells, and so many industries. 

Consequently, our group is mainly working on synthesizing various structurally functionalized complex heterocyclic compounds comprising three- or more pharmacophore unit from simple starting raw materials via carbon-carbon, and carbon-heteroatom bond formation reactions.