Laboratory of Infectious Disease Immunology and Control

Research Interest

Our laboratory studies host–pathogen interactions, focusing on infectious disease immunology, especially tuberculosis and HIV–TB co-infection. It uses multidisciplinary methods to understand immune mechanisms and develop host-directed therapies. Research includes stem cell biology, disease modeling, and precision medicine to mimic human pathology and find new treatments. The group utilizes transcriptomics, proteomics, and molecular modeling to analyze immune responses, biomarkers, and therapeutic targets. Additionally, the lab is engaged in drug discovery, repurposing, and safety and efficacy testing, emphasizing targeted delivery systems and translational research to develop innovative therapies for infectious and non-infectious diseases. 

Key Research Areas: Our research is centered on the following key areas:

• Host–Pathogen Interactions: Deciphering how pathogens modulate host immunity and how immune responses determine disease outcomes.

• Host-Directed Therapeutics: Identifying and targeting host pathways to enhance protective immunity and improve treatment efficacy.

• Stem Cells & Disease Modelling: Developing stem cell–based and organoid models to study infection and immune responses in physiologically relevant systems.

• Multi-Omics & Systems Biology: Utilizing transcriptomics, proteomics, and computational approaches to identify biomarkers and therapeutic targets.

• Drug Discovery & Precision Medicine: Exploring drug repurposing and personalized approaches for effective treatment strategies.

• Translational Research & Targeted Delivery: Advancing strategies for targeted therapeutic delivery and translating laboratory findings into clinical applications.