Publications

Kumar, R., Dhiman, P., Saini, S.K., Singh, D.* (2025). Downregulation of glycogen synthase kinase-3 beta by Urtica dioica L. contributes to neuroprotection against aluminum chloride-mediated neurotoxicity in zebrafish larvae. Molecular Neurobiology https://doi.org/10.1007/s12035-025-05235-3

Puri, S., Rahmatkar, S.N., Bora, P.S., Singh, D*., Sharma, U.* (2025). UPLC-IM-Q-TOF-MS/MS-based biochemometrics unveils neuroprotective effects of Achyranthes bidentata Blume seeds: neurochemical alterations driving neuroprotection in Zebrafish models. Food Bioscience 71, 107377.  

Kumar, A., Kumari, S., Dhiman, P., Singh, D.* (2025). Medium-chain triglycerides supplementation protects epilepsy-associated behavioral impairments in a mouse model. Journal of Biochemical and Molecular Toxicology 39, p.e 70213 

Ruchika, Kumar, A., Singh, D., Yadav, S.K., Saneja, A. (2025). Nanofibers derived self-assembled liposomes of α-lipoic acid mitigates pentylenetetrazol-induced seizures in zebrafish larvae. Food Bioscience (in press). 

Kumar, A., Saini, S.K., Singh, D.* (2025). Embryonic exposure to flaxseed oil during early development protects against seizures in zebrafish larvae via targeting BDNF/TrkB-mediated GABAergic inhibition. Food Bioscience, 68, 106701. 

Sharma, B., Rahmatkar, S.N., Kumar, N., Das, P., Singh, D*., Purohit, R.* (2025). Identification and evaluation of olefinated benzosuberene analogues as an inhibitor of phosphodiesterase-4D with efficacy in a zebrafish larva model of pentylenetetrazole-induced seizures. Chemical Engineering Journal. 507, 160272.  

Rahmatkar, S.N., Singh, D.* (2025). Decoding the role of neurotrophins in glycogen synthase kinase 3-beta regulation in Alzheimer’s disease. Molecular Neurobiology 62, 8603-8623. 

Katoch, S., Chhimwal, J., Singh, D., Kumar, D., Patial, V. (2025). Picrosides-rich fraction from Picrorhiza kurroa attenuates steatohepatitis in zebrafish and mice by modulating lipid metabolism and inflammation. Phytomedicine 137, 156368. 

Dhiman, P., Kumar, R., Singh, D.* (2025). Neuronal nitric oxide synthase activation by tadalafil protects neurological impairments in a zebrafish larva model of hyperammonemia. Life Sciences 361, 123325.  

Kumari, S., Singh, D.* (2024). Phenylthiourea-mediated experimental depigmentation reduces seizurogenic response of pentylenetetrazol in zebrafish larva. Journal of Pharmacological and Toxicological Methods 128, 107532. 

Saini, S.K., Singh, D.* (2024). Mitochondrial mechanisms in cerebral ischemia-reperfusion Injury: Unravelling the intricacies. Mitochondrion 77, 101883.

Rahmatkar, S.N., Rana, A.K., Kumar, R., Singh, D.* (2024). Fagopyrum tataricum (L.) Gaertn interacts with Gsk-3β/Nrf-2 signalling to protect neurotoxicity in a zebrafish model. Journal of Ethnopharmacology 319, 117187. 

Timilsina, K., Mishra, A., Patial, V., Gupta, M., Chaudhary, V., Singh, D.* (2024). A randomized controlled clinical trial and preclinical efficacy of an Ayurvedic formulation Arjuna Ksheerapaka Churna for dyslipidemia. Indian Journal of Traditional Knowledge 23, 1-11.

Rana, A.K., Kumar, R., Shukla, D.N., Singh, D.* (2023). Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model. Free Radical Biology and Medicine 207, 107-119. 

Sharma, S., Rana, A.K., Rahmatkar, S.N., Patial, V., Singh, D.* (2023). Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model. Journal of Ethnopharmacology 308, 116280. 

Sharma, P., Ruchika, Dhiman, P., Kumar, R., Saneja, A., Singh, D*. (2023). A solid dispersion from Citrus reticulata peel biowaste as an effective antiepileptic: Sustainable approach toward value addition and agro-industrial waste valorisation. Journal of Drug Delivery Science and Technology 81, 104283. 

Rana, A.K., Sharma, S., Kumar, R., Singh, D*. (2023). Buckwheat tartary regulates the Gsk-3β/β-catenin pathway to prevent neurobehavioral impairments in a rat model of surgical menopause. Metabolic Brain Disease 38, 1859-1875. 

Sharma, G., Rahmantkar, S.N., Rana, A.K., Sharma, P., Patial, V., Singh, D., Chowdhury, S.R. (2023). Anodal high definition transcranial direct current stimulation for neurorehabilitation of chronic stress induced depression-like behavior. IEEE Sensors 23, 12133-12145. 

Sharma, P., Dhiman, P., Singh, D*. (2023). Dietary flavonoids-rich Citrus reticulata peel extract interacts with CREB signalling to suppress seizures and linked neurobehavioral impairments in a kindling mouse model. Nutritional Neuroscience 26, 582-593. 

Kumari, S., Dhiman, P., Kumar, R., Rahmatkar, S.N., Singh, D*. (2023). Chemo-kindling in adult zebrafish alters spatial cognition but not social novelty recognition. Behavioural Brain Research 438, 114158. 

 Rana, A.K., Sharma, S., Saini, S.K., Singh, D*. (2022). Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model. European Journal of Pharmacology 925, 174973. 

Manickam, V., Dhawan, U.K., Singh, D., Gupta, M., Subramanian, M. (2022). Pomegranate peel extract decreases plaque necrosis and advanced atherosclerosis progression in Apoe-/- mice. Frontiers in Pharmacology 13, 888300.  

Rana, A.K., Sharma, S., Patial, V., Singh, D*. (2022). Lithium therapy subdues neuroinflammation to maintain pyramidal neuronal arborization and rescues neurobehavioural impairments in ovariectomized rats. Molecular Neurobiology 59, 1706-1723. 

Kumar, A., Kumari, S., Singh, D*. (2022). Insight into the cellular interactions and molecular mechanisms of ketogenic diet for comprehensive management of epilepsy. Current Neuropharmacology 20, 2034-2049.

Ruchika, Kumari, S., Dhiman, P., Singh, D., Saneja, A. (2022). R‑α-Lipoic acid conjugated to D‑α-tocopherol polyethylene glycol 1000 succinate: synthesis, characterization, and effect on antiseizure activity. ACS Journal of Agricultural and Food Chemistry 70, 7674-7682. 

Sharma, P., Dadwal, V., Rahmatkar, S.N., Gupta, M., Singh, D.* (2022). Flavonoid composition and antioxidant efficacy of citrus peels: An integrated in vitro and in silico approach toward potential neuroprotective agents. Journal of Scientific and Industrial Research 81, 445-454. 

Singh, P….., Singh, D., et al. (2022). A machine learning-based approach to determine infection status in recipients of BBV152 whole virion inactivated SARS-CoV-2 vaccine for serological surveys. Computers in Biology and Medicine 146, 105419.  

Devidas, S.B., Sendri, N., Rahmatkar, S.N., Singh, D., Bhandari, P. (2022).  Two undescribed diarylheptanoids from green husk of Carya illinoensis as acetylcholinesterase inhibitors. Natural Product Research 36, 1161-1169.

Sharma, S., Rana, A.K., Sharma, A., Singh, D*., (2022). Inhibition of mammalian target of rapamycin attenuates recurrent seizures associated cardiac damage in a Zebrafish kindling model of chronic epilepsy. Journal of Neuroimmune Pharmacology 17, 334-349.

Sharma, S., Sharma, M., Rana A.K., Joshi, R., Swarnkar, M.K., Acharya, V*., Singh, D*., (2021). Deciphering key regulators involved in epilepsy-induced cardiac damage through whole transcriptome and proteome analysis in a rat model. Epilepsia 62, 504-516. 

Rana, A. K., Rahmatkar S.N., Kumar, A., Singh, D*., (2021). Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Cytokine and Growth Factor Reviews 58, 92-101. 

Devidas, S.B., Rahmatkar S.N., Singh, R., Sendri, N., Purohit, R., Singh, D*., Bhandari P*. (2021). Amelioration of cognitive deficit in zebrafish by an undescribed anthraquinone from Juglans regia L.: An in-silico, in-vitro and in-vivo approach. European Journal of Pharmacology 906, 174234 .

Naushin, S.,…Singh, D., et al. (2021). Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV-2. eLife 2021;10:e66537.

Sharma, P., Kumari, S., Sharma, J., Purohit, R*, Singh, D*., (2021). Hesperidin interacts with CREB-BDNF signaling pathway to suppress pentylenetetrazole-induced convulsions in zebrafish. Frontiers in Pharmacology 11, 607797. 

Kaur, T., Singh, D., Pathak, D., Singh, A.P., Singh, B. (2021). Umbelliferone attenuates glycerol-induced myoglobinuric acute kidney injury through peroxisome proliferator activated receptor-γ agonism in rats. Journal of Biochemical and Molecular Toxicology 35, e22892 

Fombang, E.N., Nobossé, P., Mbofung, C.M.F. Singh, D. (2021). Impact of post harvest treatment on antioxidant activity and phenolic profile of Moringa oleifera lam leaves. Food Production, Processing and Nutrition 3, 22. 

Kaur, T., Singh, D., Singh, A.P., Pathak, D., Arora, S., Singh, B., Kaur, S., Singh, B. (2021). Stevioside protects against rhabdomyolysis-induced acute kidney injury through PPAR-γ agonism in rats. Drug Development Research 82, 59-67. 

Nobossé, P., Fombang, E.N., Singh, D., Mbofung, C.M.F. (2021). Nanoencapsulation of antioxidant-rich fraction of roasted Moringa oleifera L. leaf extract: physico-chemical properties and in vitro release mechanisms. Food and Nutrition Sciences 12, 915-936.

Rana A.K., Sharma, S., Singh, D*., (2020). Differential activation of Gsk-3β in the cortex and the hippocampus induces cognitive and behavioral impairments in middle-aged ovariectomized rat. Comprehensive Psychoneuroendocrinology 4, 100019. 

Kumari, S., Sharma, P., Mazumder, A.G., Rana, A.K., Sharma, S., Singh, D*., (2020).  Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents. Journal of Neuroscience Methods 346, 108916. 

Sharma, P., Sharma, S., Singh, D*., (2020) Apigenin reverses behavioral impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus. Nutritional Neuroscience 23, 118-127. 

Fombang, E.N., Nobosssé, P., Mbofung, C.M.F., Singh, D., (2020) Optimising extraction of antioxidants from roasted Moringa oleifera Lam. leaves using response surface methodology. Journal of Food Processing and Preservation 44, e14482. 

Sharma, P., Kumar, A., Singh, D*., (2019). Dietary flavonoids interaction with CREB-BDNF pathway: An unconventional approach for comprehensive management of epilepsy. Current Neuropharmacology 17, 1158-1175. 

Mazumder, A.G., Kumari, S., Singh, D*., (2019). Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in Zebrafish. Epilepsy Research 157, 106207. 

Mazumder, A.G., Patial, V., Singh, D*., (2019). Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy. Brain, Behavior, and Immunity 75, 84-93. 

Kumari, S., Mazumder, A.G., Bhardwaj, A., Singh, D*., (2019). Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva. Prostaglandins, Leukotrienes and Essential Fatty Acids 143, 15-20. 

Tanwar, G., Mazumder, A.G., Bhardwaj, V., Kumari, S., Bharti, R., Yamini, Singh, D., Das, P., Purohit, R., (2019). Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures. Scientific Reports (Nature) 9, 7904. 

Sharma, S., Mazumder, A.G., Rana, A.K., Patial, V., Singh, D*., (2019). Spontaneous recurrent seizures mediated cardiac dysfunction via mTOR pathway upregulation: A putative target for SUDEP management. CNS & Neurological Disorders-Drug Targets 18, 555-565. 

Rana, A.K., Singh, D*., (2018). Targeting Glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management. Neuropharmacology 139, 124-136. 

Mazumder, A.G., Sharma, P., Patial, V., Singh, D*., (2017) Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation. Journal of Ethnopharmacology 204, 8-17. 

Sharma S, Sharma P, Kulurkar P, Singh D, Kumar D, Patial V (2017). Iridoid glycosides fraction from Picrorhiza kurroa attenuates cyclophosphamide-induced renal toxicity and peripheral neuropathy via PPAR-γ mediated inhibition of inflammation and apoptosis. Phytomedicine 36, 108-117. 

Mazumder, A.G., Sharma, P., Patial, V., Singh, D*., (2017). Crocin attenuates kindling development and its associated cognitive impairments in mice via inhibiting reactive oxygen species-mediated NF-κB activation. Basic & Clinical Pharmacology & Toxicology 120, 426-433. 

Mazumder, A.G., Padwad, Y.S., Singh, D*., (2016). Anticancer mammalian target of rapamycin (mTOR) signaling pathway inhibitors: current status, challenges and future prospects in management of epilepsy. CNS & Neurological Disorders-Drug Targets 15, 945-955. 

Singh, P., Singh, D., Goel, R.K. (2016). Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: a repertoire of Glycyrrhiza glabra flavonoid antioxidants. Pharmaceutical Biology 54, 1209-1218. 

Singh, D., Goel, R.K. (2016). Anticonvulsant mechanism of saponins fraction from adventitious roots of Ficus religiosa L.: Possible  modulation of GABAergic, calcium and sodium channel functions. Revista Brasileira de Farmacognosia 26, 579-585. 

Gupta, M., Pallavi, S., Mazumder, A.G. Patial, V., Singh, D*., (2015). Dwindling of cardio damaging effect of isoproterenol by Punica granatum L. peel extract involve activation of nitric oxide-mediated Nrf2/ARE signaling pathway and apoptosis inhibition. Nitric Oxide: Biology and Chemistry 50, 105-113. 

Patial, V., Mahesh, S., Sharma, S., Partap, K., Singh, D., Padwad, Y.S. (2015). Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. Environmental Toxicology and Pharmacology 40, 445-452. 

Singh, D*. (2015). Neuropharmacological aspects of Crocus sativus L.: a review of preclinical studies and ongoing clinical research. CNS & Neurological Disorders-Drug Targets 14, 880-902. 

Singh, P., Singh, D., Goel, R.K. (2014). Ficus religiosa L. figs a potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities. Epilepsy and Behavior 41, 171-178. 

Sharma, P., Sharma, S., Patial, V., Singh, D*., Padwad, Y.S. (2014). Zebrafish (Danio rerio): a potential model for nephroprotective drug screening. Clinical Queries: Nephrology 3, 97-105.   

Singh, D., Gawande, D., Singh, T., Poroikov, V., Goel, R.K. (2014). Revealing pharmacodynamics of medicinal plants using in silico approach: A case study with wet lab validation. Computers in Biology and Medicine 47, 1-6. 

Singh, P., Singh, D., Goel, R.K. (2014). Phytoflavonoids: antiepileptics for the future. International Journal of Pharmacy and Pharmaceutical Sciences 6 51-66. 

Singh, D., Mishra, A., Goel, R.K. (2013). Effect of saponins fraction from Ficus religiosa on memory deficit, behavioral and biochemical impairments in pentylenetetrazol kindled mice. Epilepsy and Behavior 27, 206-211. 

Goel, R.K., Singh, D. (2013). Exploring selective serotonergic modulation involved in the anticonvulsant effect of Ficus religiosa fig extract. Indian Journal of Pharmacology 45, 537-538. 

Singh, B., Singh, D., Goel, R.K. (2012). Dual protective effect of Passiflora incarnata in epilepsy and its associated post-ictal depression. Journal of Ethnopharmacology 139, 273-279. 

Singh, D., Singh, B., Goel, R.K. (2012). Role of saponins for the anticonvulsant effect of adventitious roots of Ficus religiosa. Pharmaceutical Biology 50, 816-822. 

Goel, R.K., Singh, D., Lagunin, A., Poroikov, V. (2011). PASS-assisted exploration of new therapeutic potential of natural products. Medicinal Chemistry Research 20, 1509-1514 . 

Singh, D., Singh, B., Goel, R.K. (2011). Traditional uses, phytochemistry and pharmacology of Ficus religiosa: a review. Journal of Ethnopharmacology 134, 565-583. 

Singh, D., Singh, B., Goel, R.K. (2011). Hydroethanolic leaf extract of Ficus religiosa lacks anticonvulsant activity in acute electro-and chemo-convulsion mice models. Journal of Pharmaceutical Negative Results 2, 58-61. 

Singh, D., Goel, R.K. (2010). Proconvulsant potential of cyproheptadine in experimental animal models. Fundamental & Clinical Pharmacology 24, 451-455.

Kaur, H., Singh, D., Singh, B., Goel, R.K. (2010). Anti-amnesic effect of Ficus religiosa in scopolamine-induced anterograde and retrograde amnesia. Pharmaceutical Biology 48, 234-240. 

Singh, D., Goel, R.K. (2009). Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways. Journal of Ethnopharmacology 123, 330-334.

Singh, D*., Chopra, A., Dhar, V.J. (2009). Gene as a medicine: a light on gene therapy. Pharma Buzz 4, 38-43. 

*Corresponding Author 

Patents

Dhiraj Vyas, Dinesh Kumar, Damanpreet Singh, Prem Narayan Gupta, Sumeet Gairola A nutraceutical formulation for improving qualitative and quantitative sleep. (Indian Patent Application No.: 202411008806, dated 08/02/2024).

Damanpreet Singh, Amit Kumar, Savita Kumari, Shubham N Rahmatkar, Dr. Vidyashankar Srivatsan, Pooja Sharma, Vikram Patial,    Anil Kumar Rana, Supriya Sharma, Pallavi Sharma. A process for Salvia hispanica seed oil production and preparation    of   ketogenic diet from the same (Indian Patent Application No.: 202211018237; Date of e-Filing: 30/03/2022).

Pralay Das, Yamini, Richa Bharti, Shankar Ram, Vijay Kumar Bhardwaj, Rituraj Purohit, Damanpreet Singh, Prince Anand, Yogendra S. Padwad. Bioactive benzocycloheptene analogues from Himachalenes and its applications (PCT Application No.: PCT/IN2021/050993, Dated 19/10/2021; Indian Patent Application: Pub. No.: 202011045582, Dated: 22/04/2022; WIPO Pub. No.: WO/2022/085023, Dated: 28/04/2022; European Patent Application: Pub. No.: 4232441, Date: 30/08/2023; Japan Patent Application: Pub. No.: 2023548798, Date: 21/11/2023; US Patent Application: Pub. No. US 2023/0382860 A1, Date: 30/11/2023).

Book Chapters

Rahmatkar, S.N., Kumar, R., Singh, D.* Nutri-Ayur in Cognition and Memory Dysfunction. In: Anil Kumar et al. (Eds): Innovations in Ayurvedic Nutrition. Springer Nature, 2025.

Sharma, P., Singh, D.* Nanocarriers as an emerging tool for drug delivery to combat neurodegenerative diseases. In: Drug Delivery Strategy in Neurological Disorders: Challenges and Opportunities; Mishra, A., and Kulharito, H., Eds.  Springer Nature, Singapore, 2024, pp: 3-25.

Singh, D.* Cellular and molecular interactions of dietary flavonoids toward seizures suppression in epilepsy. In: Treatments, Nutraceuticals, Supplements and Herbal Medicine in Neurological Disorders; Martin, Patel, and Preedy, Eds. Academic Press Elsevier, London. 2023, pp: 305-325.

*Corresponding Author