Research

Owing to the small difference in functionality and, so, the reactivity of identical functional groups in the single molecule, there is a possibility of several reaction pathways to operate with equal probability at both the reactive sites, to yield multiple products under the given reaction condition. Under these circumstances achieving chemo and regioselectivity is a challenging task in organic synthesis. However, the selectivity of the synthetic transformations can be controlled by altering reaction parameters such as stoichiometry of reactants, temperature, catalyst, reaction time, solvent, pressure, and additives. Combining the multicomponent reactions and selectivity, with synergism, is an elegant strategy in diversity-oriented synthesis for medicinal chemist .