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Greetings of the day!
Greetings of the day!
With over 24 years of experience as a Biotechnology Professional in Plant and Microbial research, my academic journey commenced after completion of Ph.D. in 2002, as a Lecturer-against Professor Post at SOS-Biotechnology at Jiwaji University, Gwalior. In 2008, I transitioned to the position of Senior Lecturer in the Department of Bioscience and Biotechnology at Banasthali Vidyapith, Rajasthan. followed by Associate Professor (2012) in the same department, where I made significant strides in the field of molecular biology of plants and microbes, as well as their metabolites in the pharmaceutical and medical industries. In 2021, I was appointed as Associate Professor and Head of the Department of Biotechnology at NIPER Raebareli, where I have dedicated myself to provide learning environment to the research scholars in the area of Pharmaceutical Biotechnology.
Research Area
Research Area
Our laboratory is committed to natural Products, extracellular vesicles and their mechanism and wide application in medicine/food etc., Process optimization to produce API. Advancing translational research by integrating natural bioactives and nano-biotechnological platforms for innovative therapeutic strategies.
Below are the details of our work:
Isolation, characterization, and biological evaluation of exosomes derived from plants, bacteria, and animal sources, along with the assessment of their therapeutic potential and biological activities.
Isolation and characterization of endophytes from various plant explants and evaluation of their pharmaceutical and biotechnological applications.
Process development and optimization for the cost-effective production of active pharmaceutical ingredients (APIs).
Plants, Microbes, and their metabolites (API) in Pharmacy and medicine
Plants, Microbes, and their metabolites (API) in Pharmacy and medicine
It has been acknowledged that antibiotic resistance poses a significant global health challenge, both clinically and preclinically. According to the World Health Organization, it is the primary cause of approximately 1.9 million global deaths by 2019. Numerous advancements have been made to address this issue. Notably, understanding the antibiotic production genes in bacteria and fungi, along with the development of methods to modify or enhance these genes to synthesize novel potent antimicrobial agents against antibiotic-resistant bacteria, constitutes a profound biotechnological research area. Our laboratory’s focus is on the development of cost-effective antimicrobial production methods, either by optimizing the media composition or evaluating endophytic microorganisms from diverse natural sources. These approaches aim to mitigate the antimicrobial resistance burden on a national and international scale.
Exosomes
Exosomes
Exosomes are extracellular vesicles ranging from 20-200 nm in size with prominent property of carrier. It plays an important role in cell-to-cell communication. There are other extracellular vesicles found which are microvesicles (50-1000 nm) and apoptotic bodies (50-5000 nm) found in cell. All these can be distinguished based on physical appearance, size and mode of biogenesis. Biogenesis of exosomes includes inward folding of the plasma membrane, which leads to the formation of endosomes that eventually mature into multivesicular bodies. And one of the outcomes of multivesicular bodies is the release of exosomes in the extracellular space. Exosomes are well-known carriers for drug delivery, and transport of siRNA, proteins, and biotinylated DNA to distant places. As they have cargo in which they load the transferring substance to the targeted place. Meanwhile, they also participated in cell-to-cell communication and transfer the message in the form of signaling. The structure of the exosome consists of lipid bilayers, and their content includes lipid (phospholipid and glycerol), nucleic acids (miRNA, and sRNA), and protein (transmembrane protein and plasma-related protein).
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