1. Evolution of my locus of research focus
My research journey is deeply rooted in translational neuroscience, where I actively engage in various phases of research, from clinical settings to innovative applications. Currently, my postdoctoral work centers on understanding the susceptibility to ischemic stroke in healthy individuals and exploring neurorestoration strategies for patients affected by ischemic stroke. Before this, my doctoral research aimed at enhancing neuroimmunodiagnostics for Guillain–Barré Syndrome (GBS). My fascination with neuroscience began during my Master’s studies, fueling my passion for developing meaningful innovations that can positively impact people's lives. My overarching research vision is to harness the potential of Translational Neurobiology across different model systems to create innovative approaches with theranostic capabilities.
As a Research Scientist, I am spearheading the Integrated Research on Neuroscience (IRoN) initiative at the Mazumdar Shaw Center for Translational Research (MSCTR), supported by a biosafety level 2 (BSL2) laboratory. This initiative collaborates with the Narayana Institute of Neurosciences (NIN) under the Mazumdar Shaw Medical Foundation (MSMF). Currently, I am involved in two flagship projects funded by SKAN Research Trust:
2.1. HASP (Heart Attack and Stroke Predictability) Tool Program (2024-present):
This pilot study aims to develop a predictive tool for assessing the risk of strokes and heart attacks as part of a larger cohort study.
2.2. Stem Cell-Based Neuropathy Management Program (2022-present):
This project investigates the therapeutic potential of mesenchymal stem cells combined with hyperbaric oxygen therapy for managing neuropathies.
During my doctoral studies, I focused on GBS, exploring its complex relationship with infectious triggers and genetic predisposition. My thesis, titled "Guillain-Barré Syndrome: Comprehensive Profiling of Antecedent Infectious Triggers, Genetic Predisposition, Ganglioside and Ganglioside Complex Autoantibodies," addressed three key questions:
🤔 How do specific infections influence the risk and progression of GBS?
🤔🤔 What role do genetic variations in the Toll-Like Receptor (TLR) pathway play in susceptibility to GBS?
🤔🤔🤔 How do these infections shape the antibody profiles against gangliosides in GBS patients?
This work has provided valuable insights into how infections like Campylobacter jejuni and chikungunya virus are associated with GBS, as well as highlighting the significant role of TLR genes in increasing GBS risk. Our findings were supported by funding from esteemed organizations such as the Indian Council of Medical Research (ICMR) and the CDC in the USA.
📗PhD Thesis Link: https://scipost.org/theses/144/
During my Master’s program, I conducted a project on E/β thalassemia titled "Determination of the Mutations in the Beta Globin Gene of Transfusion Dependent E/β Thalassemia Patients." This project involved identifying mutations in the Human β-Globin gene and analyzing structural variations in mutant peptides. I amplified extracted DNA and then performed Sanger sequencing to correlate mutation profiles with clinical outcomes. Notably, I discovered that certain mutations could preclude hemoglobin production.
During my undergraduate studies at Burdwan Raj College, I explored animal behavior through a field study on street dogs in Burdwan.
2. Future research vision
I extrapolate my future research trajectory to intersect myriad lines of Translational Neurobiology. My proximate goal is to yield novel vistas and innovate tools that hold real value. I am determined that my research makes both sense and meaning eventually improving lives. By bridging discovery with practice, I aspire to make a mark on the well-being of individuals and communities.
See my nearest research neighbour in the Scholarometer widget: https://scholarometer.indiana.edu/#author;_0GF_iUAAAAJ;0