Research Interest

Development of chemosensors for the biologically and chemically important ionic species cations, anions and reactive species has been an active area of research of supramolecular chemistry and received great attention because of their high sensitivity, selectivity, rapid response time and versatility. Notably, we are principally following the new sensing mechanisms of interaction between receptor and analytes either by chemodosimeter approach or ligand-analytes co-ordination with various sensing mechanisms and photophysical processes like metal-ligand charge transfer (MLCT), ligand-metal charge transfer (LMCT), photoinduced electron transfer (PET), intramolecular charge transfer (ICT), paramagnetic fluorescence quenching, fluorescence resonance energy transfer (FRET), excited state intramolecular proton transfer (ESIPT), excimer/ exciplex formation as shown here.

The detection and labeling of DNA by various fluorescent probes has developed into a powerful tool as DNA-binding ligands, which are the most promising candidates as chemotherapeutic anticancer, antiviral or antibacterial drugs, because the physiological function of DNA may be changed drastically by binding with ligands through different binding modes (groove-binding or intercalation and end stacking etc). Therefore, our research group actively involve to design and synthesis of fluorescent water soluble ligand for the selective detection of different forms of DNA.