Although the tables and written draft is very comprehensive, it become not clear if the enzymes were used in all studies in purified, isolated form or maybe also as crude extract or even wildtype or recombinant whole-cell catalyst. Due to sidereactions one may assume that only purified enzymes can be applied!? Please, introduce a few words to your manuscript giving an answer to this questions. Furthermore, I would be great if you add some information on the production of the enzymes: are the wildtype enzymes produced recombinantly? are produced exclusively intracellular or are they studies using secretion to the culture medium to enable cheap and easy purification?

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