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Friends has given us 10 seasons of Thanksgiving and Christmas episodes but in season eight, in the midst of the awkward phase between Ross and Mona's relationship, instead of deciding to slow down, Ross takes huge steps forward in their romance by offering to send out a couple's holiday card when he's cornered. When he vents to the rest of the gang about his decision, they urge him to speak with Mona about the card but instead he leaves the conversation having just given her the only key to his apartment.

Objective. To investigate the safety (risk) and efficacy (benefit) of Echinacea purpurea extract in the prevention of common cold episodes in a large population over a 4-month period. Methods. 755 healthy subjects were allocated to receive either an alcohol extract from freshly harvested E. purpurea (95% herba and 5% root) or placebo. Participants were required to record adverse events and to rate cold-related issues in a diary throughout the investigation period. Nasal secretions were sampled at acute colds and screened for viruses. Results. A total of 293 adverse events occurred with Echinacea and 306 with placebo treatment. Nine and 10% of participants experienced adverse events, which were at least possibly related to the study drug (adverse drug reactions). Thus, the safety of Echinacea was noninferior to placebo. Echinacea reduced the total number of cold episodes, cumulated episode days within the group, and pain-killer medicated episodes. Echinacea inhibited virally confirmed colds and especially prevented enveloped virus infections (P < 0.05). Echinacea showed maximal effects on recurrent infections, and preventive effects increased with therapy compliance and adherence to the protocol. Conclusions. Compliant prophylactic intake of E. purpurea over a 4-month period appeared to provide a positive risk to benefit ratio.

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Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a condition that affects many of the body's systems, particularly the brain and nervous system (encephalo-) and muscles (myopathy). The signs and symptoms of this disorder most often appear in childhood following a period of normal development, although they can begin at any age. Early symptoms may include muscle weakness and pain, recurrent headaches, loss of appetite, vomiting, and seizures. Most affected individuals experience stroke-like episodes beginning before age 40. These episodes often involve temporary muscle weakness on one side of the body (hemiparesis), altered consciousness, vision abnormalities, seizures, and severe headaches resembling migraines. Repeated stroke-like episodes can progressively damage the brain, leading to vision loss, problems with movement, and a loss of intellectual function (dementia).

Bipolar II disorder is not a milder form of bipolar I disorder, but a separate diagnosis. While the manic episodes of bipolar I disorder can be severe and dangerous, individuals with bipolar II disorder can be depressed for longer periods, which can cause significant impairment.

Mania and hypomania are two distinct types of episodes, but they have the same symptoms. Mania is more severe than hypomania and causes more noticeable problems at work, school and social activities, as well as relationship difficulties. Mania may also trigger a break from reality (psychosis) and require hospitalization.

Children and teens may have distinct major depressive or manic or hypomanic episodes, but the pattern can vary from that of adults with bipolar disorder. And moods can rapidly shift during episodes. Some children may have periods without mood symptoms between episodes.

The Naruto anime was set to release new episodes in September 2023, however, so little about the project has been revealed, especially after its postponement, that many fans are concerned. Naruto Shippuden concluded in 2017, and the story of Boruto has dominated the franchise's releases since. That all changed when a four-episode return of the Naruto anime was announced in Spring 2023. However, in all that time, there has been a concerning lack of information about the anime's anticipated return.

Anime's most popular ninja, Uzumaki Naruto, recently celebrated the 20th anniversary of the studio Pierrot's adaptation. It was a big year that provided a lot for Naruto fans to celebrate. Still, it could have been even bigger if new episodes of the beloved anime aired as originally planned. Days before the first episode was supposed to air, an official announcement on the Naruto website stated that the new episodes were postponed due to quality concerns.

It's currently unclear if the writing or animation required more time. The fact that fans know so little about the project has caused speculation on whether one or both are reasons for the delay in the new anime episodes. While neither may be the case, the fact that the plot or even the animation studio behind the project is unknown has even longtime fans concerned about the lack of planning or attention the anticipated project seems to be receiving.

Since animation studio Pierrot created the previous Naruto and Boruto anime series, it will likely be the one handling the four-episode specials. However, the talented studio has more than a few high-profile series currently in production that may be preventing the work from being done on new Naruto episodes. The stunning Bleach: Thousand-Year Blood War captivated audiences and gave the end of Kurosaki Ichigo's journey the attention it deserved for years. And that barely scratches the surface of unannounced projects the studio is likely working on, like Season 5 of Black Clover, season 5 of Kingdom, and the return of the Boruto anime.

Although author Masashi Kishimoto took a very well-deserved break after completing the Naruto manga, he has become more involved with the Naruto and Boruto series in the last few years. Fans were spoiled by his incredible drawing talents and layered writing in the Minato spin-off manga, Naruto: The Whorl Within The Spiral, which was released earlier in 2023. Kishimoto has supposedly taken over writing duties for the Boruto series, meaning that he could be too busy to have input on the new Naruto anime episodes, if that's what he is planning to do.

Thankfully, the return of the Naruto anime has only been postponed and not canceled. It's encouraging that the latest message from the Naruto Anime Production Committee apologized for the delay and acknowledged that the specials planned to celebrate the original anime's 20th anniversary deserve extra care and quality to ensure they are worthy of the beloved series. For a franchise with more than its fair share of filler episodes, it sounds like those in charge of this return want to create something exceptional that will be worth the wait. Hopefully, the new Naruto anime episodes will air in 2024, giving fans a shortly-delayed 20th anniversary celebration worth of the series' legacy.

Mania must be distinguished from heightened energy and altered functioning that arises from substance use, medical conditions, or other causes. Mania is a "natural" state which is the characteristic of bipolar I disorder. A single manic phase is sufficient to make the diagnosis of bipolar I disorder, although most cases of bipolar I also involve hypomanic and depressed episodes.[3][4][5]

Rapid cycling in bipolar disorder is defined as having at least 4 or more mood episodes in a 12-month period. These mood episodes may be manic, hypomanic, or depressive but must meet their full diagnostic and duration criteria. These episodes must be separated by periods of partial or full remission of at least 2 months or be separated by a switch to an episode of opposite polarities, such as mania or hypomania to major depressive episodes. Switching from mania to hypomania or vice-versa would not qualify because they are not opposite polarity. Rapid cycling bipolar disorder patients have been found to be more resistant to pharmacotherapy.

Mania is the diagnostic criteria for bipolar I disorder, so the epidemiology of bipolar I disorder also tells us about the prevalence of mania. The lifetime prevalence of bipolar disorder is about 4 percent. Men and women are equally likely to be affected. However, women are much more likely to experience many mood episodes in a given year (rapid cycling). The median age of onset of bipolar disorder is around age 25. Men typically have an earlier age of onset than women. Studies have shown that men usually initially present with a manic episode while women present with a depressive episode. Almost two-thirds of bipolar patients have at least 1 close relative who was also diagnosed with the disease or with unipolar depression.

There are some caveats to consider with the nutritional template presented in Table 1. First, the nutritional template represents only the potential nutritional value of an adult human male. Ideally, nutritional templates for females and a range of ages would be constructed, to represent the full nutritional potential of hominin social groups (see discussion). However, data for females and sub-adults are not available within the published literature, and the collection of primary data of this nature was outside the ethical (and legal) scope of this study. Given the proxy nature of the nutritional template, one solution to the age distribution problem is to calculate the weight percent ratio of male infant, child, juvenile, and adolescent to adult, and downscale the proxy calorie value accordingly (Table 2). Male weights were used to fit the parameters of the human nutritional template and taken from the United Kingdom Royal College of Paediatrics and Child Health and World Health Organisation growth projection charts46,47. It should be kept in mind that as growth rates are not linear, the values represent a simplified reflection of reality in regards to calorie values. However, the average values presented within the broad age categories in Table 2 (infant, child, juvenile, adolescent and adult) match the age categories used in the archaeological sites under investigation (Table 3) and are therefore useful as a heuristic device when calculating the overall calorie values for episodes of Palaeolithic cannibalism. e24fc04721