Publications

(Book chapter) Identification and Profiling of Primary Metabolites Through GC-MS and Associated Data Processing

Minki Shim, Yooseong Jeong, Dong-Kyu Lee 

Natural Product Isolation and Identification: Methods and Protocols, 99-109

2025

Histone demethylase inhibitor KDM5-C70 regulates metabolomic and lipidomic programming during an astrocyte differentiation of rat neural stem cell

Minki Shim1, Thin Thin San1, Bohyun Shin, Hyojeong Lee, Sang Beom Han, Dong-Kyu Lee*, Hyun-Jung Kim*

Scientific Reports 15 (1), 5409

2025

Occurrence of organophosphate flame retardants in agricultural products from Korean markets

Eun Seon Jeong, Taek Gu Han, Jin Hwan Kim, Kyung Tae Kim, Dong-Kyu Lee, Sang Beom Han, Jong Seong Kang, Yong Seok Choi, Hyung Min Kim

Food Control 168, 110924

2025

Simultaneous determination of 12 novel brominated flame retardants and their potential exposure via the dietary intake of processed foods in Korea

Minki Shim, Ju Youn Lee, Sun Koung Joung, Hyojeong Lee, Hamin Choi, Juhyeon Kim, Hyung Min Kim, Jong Seong Kang, Yong Seok Choi, Kyung Tae Kim, Sang Beom Han*, Dong-Kyu Lee*

Food Chemistry, 142733

2025

Comprehensive contamination evaluation of organophosphate flame retardants in aquatic products across South Korea using modified QuEChERS with EDTA and LC-MS/MS

Jin Hwan Kim, Ye Bin Shin, Jun Yeop Kim, Ji Seong Kim, Woo Jae Lee, Min Kyeong Kwon, Young Min Kim, Eun Seon Jeong, Taek Gu Han, Yoon Gyoon Kim, Jong Seong Kang, Sang Beom Han, Kyung Tae Kim, Dong-Kyu Lee, Troy D Wood, Hyun Chung, Shinai Choi, Hyung Min Kim, Yong Seok Choi 

Microchemical Journal 208, 112476

2025

Prediction of human pharmacokinetic parameters incorporating SMILES information

Jae-Hee Kwon, Ja-Young Han, Minjung Kim, Seong Kyung Kim, Dong-Kyu Lee, Myeong Gyu Kim 

Archives of Pharmacal Research, 1-10

2024

Unveiling Novel Chaotropic Chromatography Method for Determination of Pralidoxime in Nerve Agent Antidote Autoinjectors

Bohyun Shin, Hyung-seung Kim, Ji-Youn Lee, Sumin Seo, Cho Hee Jeong, Eunbin Bae, Jiyu Kim, Hyojeong Lee, Donghee Lee, Dong-Kyu Lee*, Sang Beom Han* 

Separations 11 (3), 82

2024

A simple method to determine folic acid in soft-capsule-type dietary supplements using heat and ultrasound-assisted dissolution and liquid chromatography

Young Min Kim, Jun Yeop Kim, Ye Bin Shin, Min Kyeong Kwon, Jin Hwan Kim, Yoon Gyoon Kim, Dong-Kyu Lee, Sang Beom Han, Yong Seok Choi 

Analytical Science and Technology 37 (6), 339-346

2024

Optimizing analytical method in Health Functional Food code with adjustable chromatographic parameters: A case study of vitamin C

Junghoon Shin, Yooseong Jeong, Yong Seok Choi, Sang Beom Han, Dong-Kyu Lee 

Analytical Science and Technology 37 (3), 143-154

2024

Urinary metabolite biomarkers of pregnancy complications associated with maternal exposure to particulate matter

Sunwha Park, Minki Shim, Gain Lee, Young-Ah You, Soo Min Kim, Young Min Hur, Hyejin Ko, Mi Hye Park, Sung Hun Na, Young-Han Kim, Geum Joon Cho, Jin-Gon Bae, Soo-Jeong Lee, Sun Hwa Lee, Dong-Kyu Lee*, Young Ju Kim* 

Reproductive Toxicology, 108550

2024

Organophosphate flame retardants in food matrices and their analytical methods

Minh Kim Nguyen, Eun Seon Jeong, Kyung Tae Kim, Yong Seok Choi, Dong-Kyu Lee, Sang Beom Han, Jong Seong Kang, Hyung Min Kim 

Food Control, 110115

2024

Relations between Glucose and d-Amino Acids in the Modulation of Biochemical and Functional Properties of Rodent Islets of Langerhans

CJ Lee, DK Lee, IA Wei, TA Qiu, SS Rubakhin, MG Roper, JV Sweedler

ACS omega 8 (50), 47723-47734

2023

Biodistribution and racemization of gut-absorbed l/d-alanine in germ-free mice

Tian Qiu, Cindy J Lee, Chen Huang, Dong-Kyu Lee, Stanislav S Rubakhin, Elena V Romanova, Jonathan V Sweedler 

Communications Biology 6 (1), 851

2023

Chemical Decrosslinking-Based Peptide Characterization of Formaldehyde-Fixed Rat Pancreas Using Fluorescence-Guided Single-Cell Mass Spectrometry

Dong-Kyu Lee, Stanislav S Rubakhin, Jonathan V Sweedler

Analytical Chemistry 95 (16), 6732-6739

2023

Lipidomic Analysis of Cervicovaginal Fluid for Elucidating Prognostic Biomarkers and Relevant Phospholipid and Sphingolipid Pathways in Preterm Birth

Se Hee Hong, Ji-Youn Lee, Sumin Seo, Bohyun Shin, Cho Hee Jeong, Eunbin Bae, Jiyu Kim, Donghee Lee, Byungchan An, Minki Shim, Jung Hoon Shin, Dong-Kyu Lee*, Young Ju Kim*, Sang Beom Han* 

Metabolites, 13 (2), 177

2023

Hepatocellular Metabolic Abnormalities Induced by Long-Term Exposure to Novel Brominated Flame Retardant, Hexabromobenzene

Bohyun Shin, Se Hee Hong, Sumin Seo, Cho Hee Jeong, Jiyu Kim, Eunbin Bae, Donghee Lee, Jung Hoon Shin, Minki Shim, Sang Beom Han*, Dong-Kyu Lee*

Toxics, 11 (2), 101

2023

Development of a New Biomarker Model for Predicting Preterm Birth in Cervicovaginal Fluid 

Ji-Youn Lee, Sumin Seo, Bohyun Shin, Se Hee Hong, Eunjin Kwon, Sunwha Park, Young Min Hur, Dong-Kyu Lee*, Young Ju Kim*, Sang Beom Han* 

Metabolites 2022, 12(8), 734
2022

Removing Formaldehyde‐Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin‐Fixed Paraffin‐Embedded Tissues 

Dong‐Kyu Lee, Stanislav S Rubakhin, Irina Kusmartseva, Clive Wasserfall, Mark A Atkinson, Jonathan V Sweedler 

Angewandte Chemie International Edition, 59 (50), 22584-22590

2020 

SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity 

Da Hyun Lee, Jeong Su Park, Yu Seol Lee, Jisu Han, Dong-Kyu Lee, Sung Won Kwon, Dai Hoon Han, Yong-Ho Lee, Soo Han Bae 

Autophagy, 16 (11), 1949-1973 

2020

Research quality-based multivariate modeling for comparison of the pharmacological effects of black and red ginseng 

Dong-Kyu Lee, Seongoh Park, Nguyen Phuoc Long, Jung Eun Min, Hyung Min Kim, Eugine Yang, Seul Ji Lee, Johan Lim, Sung Won Kwon 

Nutrients, 12 (9), 2590 

2020

Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates multiorgan development in zebrafish 

Yong‐Il Kim, In‐Koo Nam, Dong‐Kyu Lee, Sushil Bhandari, Lennart Charton, SeongAe Kwak, Jae‐Young Lim, KwangHeum Hong, Se‐Jin Kim, Joon No Lee, Sung Won Kwon, Hong‐Seob So, Nicole Linka, Raekil Park, Seong‐Kyu Choe 

Journal of Cellular Physiology, 235 (1), 151-165 

2020

Uptake of nanopolystyrene particles induces distinct metabolic profiles and toxic effects in Caenorhabditis elegans

Hyung Min Kim, Dong-Kyu Lee, Nguyen Phuoc Long, Sung Won Kwon, Jeong Hill Park* 

Environmental pollution, 246, 578-586

2019

Integrative lipidomic and transcriptomic analysis of X-linked adrenoleukodystrophy reveals distinct lipidome signatures between adrenomyeloneuropathy and childhood cerebral adrenoleukodystrophy

Dong-Kyu Lee, Nguyen Phuoc Long, Juwon Jung, Tae Joon Kim, Euiyeon Na, Yun Pyo Kang, Sung Won Kwon*, Jiho Jang* 

Biochemical and biophysical research communications, 508 (2), 563-569

2019

The antidiabetic drug lobeglitazone protects mice from lipogenesis-induced liver injury via mechanistic target of rapamycin complex 1 inhibition

Yu Seol Lee, Jeong Su Park, Da Hyun Lee, Dong-Kyu Lee, Sung Won Kwon, Byung-Wan Lee, Soo Han Bae* 

Frontiers in endocrinology, 9, 539

2018

In Vitro Tracking of Intracellular Metabolism-Derived Cancer Volatiles via Isotope Labeling

Dong-Kyu Lee, Euiyeon Na, Seongoh Park, Jeong Hill Park, Johan Lim, Sung Won Kwon* 

ACS central science, 4 (8), 1037-1044

2018

Non-destructive profiling of volatile organic compounds using HS-SPME/GC–MS and its application for the geographical discrimination of white rice

Dong Kyu Lim, Changyeun Mo, Dong-Kyu Lee, Nguyen Phuoc Long, Jongguk Lim, Sung Won Kwon* 

journal of food and drug analysis, 26 (1), 260-267

2018

Integrated transcriptomic and metabolomic analysis of five Panax ginseng cultivars reveals the dynamics of ginsenoside biosynthesis

Yun Sun Lee1, Hyun-Seung Park1, Dong-Kyu Lee, Murukarthick Jayakodi, Nam-Hoon Kim, Hyun Jo Koo, Sang-Choon Lee, Yeon Jeong Kim, Sung Won Kwon, Tae-Jin Yang* 

Frontiers in plant science, 8, 1048

2017

Comparative analysis of the transcriptomes and primary metabolite profiles of adventitious roots of five Panax ginseng cultivars

Yun Sun Lee1, Hyun-Seung Park1, Dong-Kyu Lee1, Murukarthick Jayakodi, Nam-Hoon Kim, Sang-Choon Lee, Atreyee Kundu, Dong-Yup Lee, Young Chang Kim, Jun Gyo In, Sung Won Kwon*, Tae-Jin Yang*

Journal of ginseng research, 41 (1), 60-68

2017

Solid‐phase extraction assisted dispersive liquid–liquid microextraction based on solidification of floating organic droplet to determine sildenafil and its analogues in …

Jing Li, Si Hun Roh, Jia Shaodong, Ji Yeon Hong, Dong‐Kyu Lee, Byong‐kyu Shin, Jeong Hill Park, Jeongmi Lee, Sung Won Kwon* 

Journal of separation science, 40 (15), 3120-3129

2017

A 1H NMR-based metabolomics approach to evaluate the geographical authenticity of herbal medicine and its application in building a model effectively assessing the mixing proportion of intentional admixtures: A case study of Panax ginseng: Metabolomics for the authenticity of herbal medicine…

Huy Truong Nguyen, Dong-Kyu Lee, Young-Geun Choi, Jung-Eun Min, Sang Jun Yoon, Yun-Hyun Yu, Johan Lim, Jeongmi Lee, Sung Won Kwon, Jeong Hill Park*

Journal of pharmaceutical and biomedical analysis, 124, 120-128

2016

UPLC-QTOFMS based metabolomics followed by stepwise partial least square-discriminant analysis (PLS-DA) explore the possible relation between the variations in secondary metabolites and phylogenetic divergences of the genus Panax

Huy Truong Nguyen1, Dong-Kyu Lee1, Won Jun Lee, GwangJin Lee, Sang Jun Yoon, Byong-kyu Shin, Minh Duc Nguyen, Jeong Hill Park, Jeongmi Lee*, Sung Won Kwon* 

Journal of Chromatography B 2016, 1012, 61-68

2016

Metabolic response induced by parasitic plant-fungus interactions hinder amino sugar and nucleotide sugar metabolism in the host

Dong-Kyu Lee1, Soohyun Ahn, Hae Yoon Cho, Hye Young Yun, Jeong Hill Park, Johan Lim, Jeongmi Lee, Sung Won Kwon* 

Scientific reports, 6 (1), 1-11

2016

Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media

Kyung Min Jeong, Min Sang Lee, Min Woo Nam, Jing Zhao, Yan Jin, Dong-Kyu Lee, Sung Won Kwon, Ji Hoon Jeong, Jeongmi Lee* 

Journal of Chromatography A, 1424, 10-17

2015

Non-invasive characterization of the adipogenic differentiation of human bone marrow-derived mesenchymal stromal cells by HS-SPME/GC-MS

Dong-Kyu Lee1, TacGhee Yi1, Kyung-Eun Park, Hyun-Joo Lee, Yun-Kyoung Cho, Seul Ji Lee, Jeongmi Lee, Jeong Hill Park, Mi-Young Lee, Sun U Song*, Sung Won Kwon* 

Scientific reports, 4 (1), 1-8

2014

Evaluation of four different analytical tools to determine the regional origin of Gastrodia elata and Rehmannia glutinosa on the basis of metabolomics study

Dong-Kyu Lee1, Dong Kyu Lim, Jung A Um, Chang Ju Lim, Ji Yeon Hong, Young A Yoon, Yeonsuk Ryu, Hyo Jin Kim, Hi Jae Cho, Jeong Hill Park, Young Bae Seo, Kyunga Kim, Johan Lim, Sung Won Kwon*, Jeongmi Lee* 

Molecules, 19 (5), 6294-6308

2014

Comparison of primary and secondary metabolites for suitability to discriminate the origins of Schisandra chinensis by GC/MS and LC/MS

Dong-Kyu Lee1, Min Hye Yoon, Yun Pyo Kang, Jin Yu, Jeong Hill Park, Jeongmi Lee*, Sung Won Kwon* 

Food chemistry, 141 (4), 3931-3937

2013

Discrimination between genetically identical peony roots from different regions of origin based on 1 H-nuclear magnetic resonance spectroscopy-based metabolomics: determination of the geographical origins and estimation of the mixing proportions of blended samples

Jung A Um, Young-Geun Choi, Dong-Kyu Lee, Yun Sun Lee, Chang Ju Lim, Young A Youn, Hwa Dong Lee, Hi Jae Cho, Jeong Hill Park, Young Bae Seo, Hsun-chih Kuo, Johan Lim, Tae-Jin Yang, Sung Won Kwon*, Jeongmi Lee*

Analytical and bioanalytical chemistry, 405 (23), 7523-7534

2013

Analysis of the composition of trail pheromone secreted from live Camponotus japonicus by HS-SPME GC/MS (HeadSpace-Solid Phase MicroExtraction Gas Chromatography/Mass Spectrometry)

Kyung-Eun Park, Dong-Kyu Lee, Sung Won Kwon, Mi-Young Lee*

Analytical Science and Technology, 25 (5), 292-299

2012