1930s America. Commissioner of the Federal Bureau of Narcotics, Harry J. Anslinger, grapples with a growing sense of internal conflict. Prohibition has ended, and alcohol once again flows freely through the veins of the nation. Meanwhile, the country is gripped by the worst economic depression the world has ever seen.

Swarms of unemployed citizens scatter the streets. They seek refuge from these terrible times by any means necessary - tobacco, alcohol, opium. Joining this list of American consumables is a newly declared evil. A "Mexican weed with roots in hell" known as "marijuana", that is used by various people of colour in the U.S. 

With the help of a savvy advertising man, Anslinger sets out to tarnish marijuana's image by linking it to everything that white Americans fear most: minorities, immigrants, and even the devil himself. 

As marijuana spreads through the nation, Anslinger is prompted to seek help from sources in the field. In a covert sting operation in Louisiana, he will require a WWI black veteran Gary O'Neill, to investigate the Jazz community and destroy the source of trafficking. Changing the public's opinion will require the help of John and Jane, anti-drug christian activists who will lead the creation of marijuana propaganda.

The plan is convoluted, dirty, and racist-the perfect mix for effective change in the U.S. Ignorant to Anslinger's true agenda, O'Neill and John & Jane are made to believe they are doing God's work on earth; but Anslinger's unholy alliance will prove to sow nothing but greed and destruction in the ever- decaying land of the free.