Publications

Co(II)-Catalyzed Additive-Free Transfer Hydrogenation of N-Heteroarenes at Room TemperatureTraditional catalyst development relies on multistep synthesis and isolation of ligand and precatalyst. Designing a catalytic system that can be assembled in situ from easily accessible starting materials can decrease the reaction complexity and enhance the synthetic utility. Herein, we report an inexpensive and commercially available CoBr2·H2O/terpyridine-catalyzed effective and straightforward transfer hydrogenation (TH) protocol for N-heteroarenes, utilizing NH3·BH3 (AB) under ambient conditions. Synthesis of diverse substrates and bioactive molecules demonstrated a practical applicability. Control experiments and DFT studies elucidate the mechanism.

Ligand-modulated phosphine-free Ni(II) complexes for Z-selective semi-transfer hydrogenation of alkynes and dual transfer hydrogenation of α,β-unsaturated ketones using ammonia boraneStereoselective semi-transfer hydrogenation of alkynes is highly challenging due to issues with cis/trans-isomerization and over-reduction. Similarly, achieving simultaneous hydrogenation of both C [[double bond, length as m-dash]] O and C [[double bond, length as m-dash]] C bonds in α,β-unsaturated ketones pos...

Methyl Formate, an Alternative Transfer Hydrogenating Agent for Chemoselective Reduction of N-Heteroarenes and AzoarenesThe search for efficient molecular hydrogen precursors and their catalytic exploration is necessary for the evolution of catalytic transfer hydrogenation. Methyl formate (MF) having high hydrogen content still remains unexplored for such transformations. Herein, we disclosed a bifunctional Ir(III)-complex catalyzed chemoselective TH protocol for N-heteroarenes and azoarenes using MF. A variety of substrates including ten bioactive molecules have been synthesized under mild reaction conditions. A probable mechanistic pathway was proposed based on control experiments and mechanistic studies.

Utilization of methanol for condensation interrupted chemoselective transfer hydrogenation of CC, CO, and CN bonds under low catalyst loadingSelective transfer hydrogenation (TH) of unsaturated molecules using methanol is challenging as the in situ generated formaldehyde is prone to react with the active methylene (C-methylation) or amine (N-methylation) core of the desired product. In this work, an effective protocol is demonstrated for the sele

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