Embedded Files
Towards Personalised Medicine: Balancing Risks vs Benefits
Diclofenac and its uses
Diclofenac and its uses
What is Diclofenac?
What is Diclofenac?
Diclofenac is a non- steroidal anti-inflammatory drug (NSAID). It is commonly used for it's anti-inflammatory, analgesic, and antipyretic effects1.
Available as Diclofenac Sodium (slow acting) and Diclofenac Potassium (fast acting).
Mode of Action
Mode of Action
Diclofenac acts to suppress Prostaglandin production. Prostaglandins are a group of chemicals responsible for inflammation and pain.
Diclofenac inhibits Prostaglandin synthesis via the Cyclooxygenase (COX) 1 and 2 enzyme pathways1,2.
Administration
Administration
Common routes of administration in adults are Oral or Intravenous (IV) or Intramuscular (IM), in the following doses3:
Oral: 75–150 mg daily in 2–3 divided doses.
IV (pre-operatively in hospital settings): 75 mg, then 75 mg after 4–6 hours if required for a maximum of 2 days; maximum 150 mg per day.
IM: 75 mg 1–2 times a day for maximum 2 days
Other modes of Administration3:
Topical: Generally, found as 1% gel where 1g of gel contains 10mg of Diclofenac
Rectal: 75–150 mg daily in divided doses. For not more than 48 hours.
For more detailed information please visit the following websites:
https://bnf.nice.org.uk/drug/diclofenac-sodium.html and https://bnf.nice.org.uk/drug/diclofenac-potassium.html (Adults)
https://bnfc.nice.org.uk/drug/diclofenac-sodium.html (48) and https://bnfc.nice.org.uk/drug/diclofenac-potassium.html (49) (Children)
Toxicokinetic Profile
Toxicokinetic Profile
Toxicokinetics– The study of how the body responds to a Xenobiotic (substance found within the body that is not naturally occurring in the body)
The body’s response to Diclofenac is characterised by the following processes;
The main organs involved in these processes, making them susceptible to toxic events, are the Gastrointestinal Tract, Liver, Renal and Cardiovascular Systems.
References (4) and (5) can be found in our website Bibliography
Please click the links below.
Page updated
Google Sites
Report abuse