Bio-signal processing
We measure data through invasive and non-invasive measuring methods to understand bio-systems such as the brain and senses. In most cases, researchers use non-invasive procedures to measure human data. To investigate deep brain tissue, we use an invasive measurement method. We try to understand the bio/brain system by analyzing acquired data.
Problem definition
- Bio-signal is hard to process and analyze based on its non-stationary property due to complex bio-system.
Research Objectives
- Development of sequential biological signal specific signal processing method with some supervision of domain.
How the lab is trying to solve (previous/future research)
- Signal processing techniques & AI
Neuromodulation
Neuromodulation is a research area that studies how to modulate neural circuits well to improve the quality of life for patients with neurological diseases. In the case of neurodegenerative diseases, the exact mechanism has not yet been identified. Therefore, various methods, such as drug prescription and electrical stimulation, are being studied, and precise treatment has yet to be found. Drug-based treatment has the advantage of treating patients by oral administration or injection without surgery.
However, there are two difficulties in drug treatment. First is the drug resistance. Second is the low transparency of drugs to the brain due to a blood-brain barrier (BBB). For these two reasons, in the end, drug-based treatment doesn't work. For these reasons, electrical stimulation methods such as deep brain stimulation (DBS) are used, and it is known to control Parkinson's syndrome well.
We are interested in enhancing the performance and useability of electrical stimulation devices (e.g., DBS systems). For example, we are developing a fully implanted wireless closed-loop DBS system by working with various institutions.
We believe an enhanced DBS system can bring a big jump in Parkinson’s patients. Also, we can use this system to understand the underlying mechanisms of neurodegenerative diseases.
Problem definition
- Currently available drug-based therapy for neurodegenerative diseases such as Parkinson’s diseases are not effective in long-term therapy.
Research Objectives
- Development of fully implanted closed loop deep brain stimulation system. - System optimizes stimulation parameter based on closed loop feedback with reinforcement agent
How the lab is trying to solve (previous/future research)
- More compact board for recording and stimulation that can record high quality brain signal.
- Automation of manual stimulation parameter tuning process by using reinforcement learning.
Artificial sense
The five senses of humans are critical since we absorb the world using our senses. The harmony of the sensing organ and brain does sensing. We look at this phenomenon as a system that mimics an artificial system.
Our current interests are a sense of touch and smell. Since both work needs an accurate sensor, we collaborate with other institutes. Both artificial systems have a similar workflow. Both systems sense touch or smell through the sensor. Artificial intelligence is used to model complex non-linear sense-to-cognitive output relationships.
Making an artificial system has various strengths. However, the most significant strength is that this system can be adapted to multiple applications, such as mobile devices.
Problem definition
- Artificial tactile, smell system is complex to modify.
Research Objectives
- Development of artificial sensory system that mimics human sensing system.
How the lab is trying to solve (previous/future research)
- Using signal processing, linear/non-linear modeling techniques like AI to model the complex sense to cognitive decision relationships.
The prefrontal circuit motifs in healthy brain and brain with emotional abnormalities(KBRI)
Minimum invasive AI-based E-brain development for brain disease relief (MSIP)
Development of core technology for fusion interface based on high efficiency sensors mimicking human five senses(NRF)
Development of multi-modal sensing and control for brain functional homeostasis (NRF)
Development of mobile platform for Alzheimer’s disease (AD) diagnosis and relief using AI based neuro-feedback(NRF)
Development of fusion parts for 3.5 Tesla 6 channel magnetic stimulation and information feedback for a cure for intractable brain disease(MEST),
Rehabilitation and replacement technology for brain damage employing electrical method(MSIP)
Development of microbiorobotic systems for surgical treatment of chronic total occlusion(MEST)
Physiological tactile sensor developments(Samsung Electronics)
Development of bi-directional multi-channel neural electrodes and implantable wireless power/data transmission modules(NRF)
IEEE Engineering in Medicine and Biology Society https://www.embs.org/
Organization for Computational Neurosciences https://www.cnsorg.org/
Society for Neuroscience https://www.sfn.org/
The Society for functional Near Infrared Spectroscopy (SfNIRS) https://fnirs.org/
The Korean Society for Brain and Neural Sciences (KSBNS, 한국뇌신경과학회) http://www.ksbns.org/
Korean Society for EEG and Neurophysiology (KEEG, 대한뇌파신경생리학회) https://keeg.or.kr/index.htm?
Brain Engineering Society of Korea (BESK,한국뇌공학회) http://besk.kr/
The Korean Society of Medical & Biological Engineering (KOSOMBE, 대한의용생체공학회) http://www.kosombe.or.kr/
Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) https://embc.embs.org/
IEEE International Winter Conference on Brain-Computer Interface https://brain.korea.ac.kr/bci2018/registration/registration.php
Organization for computational neuroscience (CNS) https://www.cnsorg.org/calendar
Society for Neuroscience SFN https://www.sfn.org/meetings/calendar
KSBNS Conference https://www.ksbns.org/notice/?gbn=2&htop=MN0005&ctop=MN0032&ptop=MN0005
KEEG Conference https://keeg.or.kr/index.htm