Atmospheric Pressure Mass Spectrometry Imaging System
Atmospheric Pressure Mass Spectrometry Imaging System
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Goal
Goal
Development of novel atmospheric pressure mass spectrometry (AP-MS) imaging method based on nanomaterial-assisted (pulse/CW) laser desorption and subsequent non-thermal plasma induced ionization. Efficient laser desorption techniques for bio-molecule sampling using nanomaterials (AuNPs/AgNps, Go/rGO nanosheets, carbon dots, and MoS2), graphene-layer substrate, and AuNP-layer substrate.
Atmospheric pressure mass spectrometry (AP-MS) imaging
Atmospheric pressure mass spectrometry (AP-MS) imaging
Atmospheric pressure mass spectrometry (AP-MS) imaging is a member of the mass spectrometry (MS) imaging family, in which ionization occurs at atmospheric pressure with the samples being analyzed in their native state. In ambient desorption/ionization, 1) the surface is sampled with minimal or no preparation, 2) ionization occurs externally to the mass spectrometer, and 3) ion, not the entire sample, are introduced into the mass spectrometer.
The AP-MS imaging system with an efficient desorption procedure using focused lasers with an aid of nanomaterials and a subsequent AP-plasma ionization step shows detailed chemical information of biological tissue with micrometer spatial resolution.
Transmission-mode laser configuration
Transmission-mode laser configuration
The transmission-mode laser configuration provides precise desorption performance to facilitate MS imaging. The transmission-mode laser configuration and the use of nanomaterial-coated substrates show greatly improved laser desorption performance, and the desorbed biomolecules inevitably meet the atmospheric pressure helium plasma medium, resulting in AP-MS imaging.
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