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Our Research
Cancerous cells accumulate numerous harmful genetic aberrations, yet they can override normal cellular checkpoints and continuously proliferated. They seem to do so, in part, by taking advantage of cellular recovery pathways. We aim to identify new pathways that cancers rely on for survival, with the ultimate goal of providing new anti-cancer therapeutic logistics.
Research Summary
Research Summary
Maintenance of genomic integrity is essential for all life forms. Loss of genomic integrity can lead to various abnormalities, including cell death, aging, and cancers. Understanding the molecular processes that preserve genomic integrity is important in biological and clinical sciences.
Research Summary
Research Summary
Cancers develop therapy resistance via multiple mechanisms. Some of these refractory cancers may rely on heightened activites of genomic-stabilizing pathways. We use synthetic lethality approaches to identify new genetic dependencies of cancers.
Research Summary
Research Summary
We employ a range of experimental tools to decipher funcional and structural features of genomic-stabilizing factors. These information may provide new avenues for anti-cancer strategies.
Research Tools
Cell-based imagings
Cell-based imagings
DNA Fiber single molecule analysis
DNA Fiber single molecule analysis
Recombinant Protein purification
Recombinant Protein purification
Isolation of Proteins at Nascent Forks
Isolation of Proteins at Nascent Forks
CRISPR genome editing & synthetic lethality screens
CRISPR genome editing & synthetic lethality screens
Cancer mutations database analysis
Cancer mutations database analysis
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