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Vocative agents
Neurovascular pain may be influenced by alpha androgenic blocking action of ergotamine tartrate, which causes stimulating effect on smooth muscles of peripheral and cranial vessels. It is available with or without addition of caffeine. Caffeine enhances vasoconstricting effect
Vocative agents are contraindicated in coronary heart diseases, pregnancy and increased blood pressure [14].
Non-epinephrine blockers
Guanethiine and reserpine appears to block the uptake of nor-epinephrine by sensitized axons used in treatment of orofacial pain by blocking satellite ganglion. These are commonly used in rheumatoid arthritis.
Antimicrobials
These are introduced systemically after culture and sensitivity. This decreases pain by decreasing the inflammation that is their enzymes and byproducts .
Neurolytic agents
95% of ethyl alcohol is used to destroy peripheral nerve. Sometimes phenol is added to, it provides long-term temporary relief. The disadvantages are local fibrosis, not used commonly. Injection of 0.3 ml of glycerol into retrogasserion space for treatment of trigeminal neuralgia reported that 90% patient pain free. No dysesthesia or anesthesia, dolorosa observed, glycerol acts on demylinated axons assumed to be involved in triggering neuralgia.