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The antidepressant drugs, L-Monoamine oxidases (MAO) inhibitor acts to increase concentration of serotonin, dopamine and nor-epinephrine in CSF by educing the natural breakdown through an inhibitory action on the enzyme MAO. Aspirin produces anti-inflammatory afferent by the action of enzyme cyclooxygenase, which normally metabolizes arachidonic acid into prostaglandin as a result of local injury. Drugs give both intentional and intentional effects when two or more drugs are combined their interaction should be understood some combinations are incompatible. Some drugs potentate action of others to determine proper dose one should familiar with drugs half life and plasma concentrate. Many things to be known about medications are: indications, con-traindications, incompatibility, mode of action mode of administration, safety toxicity complications idiosyncrasy, anaphylaxis and other unwanted reactions.
Analgesic Agents
As a general rule the objective of analgesic should not be to eliminate pain altogether. Pain has some value in monitoring progress in patient’s condition. It helps and guides the patients when his actions are excessive or abusive the main objective of analgesic is to make pain tolerable to the patient [6].
Non-narcotic analgesics
These include aspirin and NSAIDS, which have analgesic, antipyretic, anti-platelet, anti-inflammatory actions. They differ from narcotic analgesic in that they presumably prevent the formation of prostaglandin E1 by inhibitory action on enzyme, cyclooxygenase. They don’t produce tolerance, physical dependence or addiction they have ceiling effect where by increases dose beyond peak point dose not increase an-algesic effect, but may effect duration of analgesic. Acetaminophen and chloride magnesium trisalicylate are included in non-narcotic group they lack anti platelet and inflammatory action. They are used in treatment of mild to moderate pain and chronic pain. Aspirin and NSAIDS are contraindicated with anticoagulant therapy and other coagulation deficiency condition .