Embedded Files
Patents
Patents
6. Ramakrishnan, R.; Parmar, K.; Chakravortty, D.* and Das, D.* Enzymatic prevention of biofilms. (Patent application filed, July 2025).
5. Rajendran, K.; Ramachandran, V. and Das, D.* A Biocatalytic system for steroid hydroxylation. (Patent application filed, Jan 2025).
4. Sidhu, J. S.; Rajendran, K.; Mathew, A. B.; Iqbal, T. ; Saini, D. K. and Das, D.* Naphthalimide-based compounds, probe and methods thereof. (Patent application filed, March 2024).
3. Iqbal, T.; Murugan, S. and Das, D.* An engineered cell for hydrocarbon biosynthesis. (Patent application filed, June 2023).
2. Iqbal, T.; Murugan, S. and Das, D.* A Biocatalytic system and method for production of terminal alkenes. (Patent granted, Indian Patent No. 569548, Aug 2025)
1. Ramakrishnan, R.; Nair, A. V.; Parmar, K.; Chakravortty, D.* and Das, D.* Enzymatic dispersion of biofilms. (Patent granted, Indian Patent No. 524536, March 2024)
Publications
Publications
24. Sidhu, J. S.;* Singh, K.; Kaur, G.; and Das, D. Recent advancements in parallel and tandem reaction-based fluorogenic probes for tracing enzymatic activities.
Trends in Analytical Chemistry , 2025, https://www.sciencedirect.com/science/article/pii/S016599362500264X?dgcid=author
23. Ramakrishnan, R.; Nair, A. V. ; Parmar, K.; Chakravortty, D * and Das, D.* Combating Biofilm-Associated Klebsiella pneumoniae Infections Using a Bovine Microbial Enzyme.
npj Biofilms and Microbiomes, 2024, https://doi.org/10.1038/s41522-024-00593-7
This work is highlighted by Nature India
22. Iqbal, T.; Murugan, S. and Das, D.* A Chimeric Membrane Enzyme and an Engineered Whole-cell Biocatalyst for Efficient 1-Alkene Production. Science Advances, 2024, https://www.science.org/doi/10.1126/sciadv.adl2492
This work is highlighted by Nature India
21. Murugan, S.; Iqbal, T. and Das, D.* Functional Production and Biochemical Investigation of an Integral Membrane Enzyme for Olefin Biosynthesis. Protein Science, 2024, https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.4893
20. Iqbal, T.; Murugan, S.; Rajendran, K.; Sidhu, J. S. and Das, D.* Unraveling the Conversion of Fatty Acids into Terminal Alkenes by an Integral Membrane Enzyme, UndB. ACS Catalysis, 2023, https://pubs.acs.org/doi/full/10.1021/acscatal.3c04171
[This article is featured on the Front Cover of the journal, featured by IISc News, and the magazine KERNEL]
[This article is featured as one of the best articles published in ACS Catalysis in the past 3 years]
19. Sidhu, J. S.; Rajendran, K.; Mathew, A. B.; Iqbal, T. ; Saini, D. K. and Das, D.* Acetylcholine structure-based small activatable fluorogenic probe for specific detection of acetylcholinesterase, Analytical Chemistry, 2023, https://pubs.acs.org/doi/full/10.1021/acs.analchem.3c00099
[This article is captured by IISc Press, PhysOrg, and several leading newspapers: Times of India, Hindustan Times, Deccan Herald, India Today, Today Headline, The Week Magazine, ET Healthworld, MedIndia, Mirage News, Latest LY, Alzforum etc.]
18. Rajendran, K.; Dey, R.; Ghosh, A. and Das, D.* In search of biocatalytic remedy for organotin compounds- the recalcitrant eco-toxicants. Biophysical Chemistry, 2022, https://doi.org/10.1016/j.bpc.2022.106888
17. Ramakrishnan, R.; Singh, A. K.; Singh, S.; Chakravortty, D. and Das, D.* Enzymatic Dispersion of Biofilms: An Emerging Biocatalytic Avenue to Combat Biofilm-Mediated Microbial Infections. Journal of Biological Chemistry, 2022, https://doi.org/10.1016/j.jbc.2022.102352
16. Iqbal, T. and Das, D.* Biochemical Investigation of Membrane-Bound Cytochrome b5 and Catalytic Domain of Cytochrome b5 Reductase from Arabidopsis Thaliana. Biochemistry, 2022, https://doi.org/10.1021/acs.biochem.2c00002
[This article is featured on the Front Cover of the journal]
15. Iqbal, T.; Chakraborty, S.; Murugan S. and Das, D.* Metalloenzymes for Fatty Acid-Derived Hydrocarbon Biosynthesis: Nature's Cryptic Catalysts. Chemistry - An Asian Journal, 2022 https://doi.org/10.1002/asia.202200105
[This article is featured on the Front Cover of the journal]
14. Ray, L. C.‡; Das, D.‡; Entova, S.; Lukose, V.; Lynch, A. J.; Imperiali, B.*; and Allen, K. N.* “Membrane Association of Monotopic Phosphoglycosyl Transferase Underpins Function.” Nature Chem. Biol. 2018, 14, 538-541. (‡ co-first author) [This article has been highlighted by C&EN magazine] [This article is featured by F1000Prime as being of special significance.]
13. Madec, A.G.E.; Nathaniel S. Schocker, N. S.; Sanchini, S.; Myratgeldiyev, G.; Das, D.; Imperiali, B.* "Facile Solid-Phase Synthesis and Assessment of Nucleoside Analogs as Inhibitors of Bacterial UDP-Sugar Processing Enzymes." ACS ChemBio., 2018, 13, 2542-2550.
12. Das, D.; Kuzmic, P; and Imperiali, B.* “Analysis of a Dual Domain Phosphoglycosyl Transferase Reveals a Ping-Pong Mechanism with a Covalent Enzyme Intermediate.” Proc. Natl. Acad. Sci. U.S.A., 2017, 114, 7019-7024. [This article is featured by F1000Prime as being of special significance.]
11. Das, D.; Walvoort, M. T. C.; Lukose, V.; and Imperiali, B.* “A Rapid and Efficient Luminescence- based Method for Assaying Phosphoglycosyltransferase Enzymes” Sci. Rep., 2016, 6, 33412. [This article has been highlighted by Promega.]
10. Ellington, B.; Paul, B.; Das, D.; Vitek, A. K.; PM Zimmerman, P. M.; Marsh, E. N. G.* “An Unusual Iron-Dependent Oxidative Deformylation Reaction Providing Insight into Hydrocarbon Biosynthesis in Nature” ACS Catalysis, 2016, 6, 3293–3300.
9. Buer, B.; Paul, B.; Das, D.; Stucky, J.; and Marsh, E. N. G.* “Insights Into Substrate and Metal Binding From the Crystal Structure of Cyanobacterial Aldehyde Deformylating Oxygenase with Substrate Bound” ACS ChemBio., 2014, 9, 2584-2593.
8. Das, D.; Ellington, B.; Paul, B.; and Marsh, E. N. G.* “Mechanistic Insights from Reaction of α- Oxiranyl-Aldehydes with Cyanobacterial Aldehyde Deformylating Oxygenase” ACS ChemBio., 2014,9, 570-577.
7. Lin, F.; Das, D.; Lin, X.; and Marsh; E. N. G.* “Aldehyde-Forming Fatty Acyl-CoA Reductase from Cyanobacteria: Expression, Purification and Characterization of the Recombinant Enzyme” FEBS Journal, 2013, 280, 4773-4781.
6. Khara, B.; Menon, N.; Levy, C.; Mansell, D.; Das, D.; Marsh, E. N. G.; Leys, D., and Scrutton. N. S.* “Production of Propane and Other Short Chain Alkanes by Structure-based Engineering of Ligand Specificity in Aldehyde Deformylating Oxygenase” ChemBioChem, 2013, 14, 1204-1208. [This article has been featured as an excellent work in the Angew. Chem. Int. Ed., 2013, 52, 7344-7347.]
5. Paul, B.;‡ Das, D.;‡ Ellington, B.;‡ and Marsh, E. N. G.* “Probing the Mechanism of Cyanobacterial Aldehyde Decarbonylase Using a Cyclopropyl Aldehyde” J. Am. Chem. Soc., 2013, 135, 5234-5237. (‡ co-first author)
4. Eser, B. E.;‡ Das, D.;‡ Han, J.; Jones, P. R.; and Marsh, E. N. G.* “Oxygen Independent Alkane Formation by Non-Heme Iron-Dependent Cyanobacterial Aldehyde Decarbonylase: Investigation of Kinetics andRequirement for an External Electron Donor” Biochemistry, 2011, 50, 10743-10750. (‡ co-first author)
3. Das, D.;‡ Eser, B. E.;‡ Han, J.; Sciore, A.; and Marsh, E. N. G.* “Oxygen-independent Decarbonylation ofAldehydes by Cyanobacterial Aldehyde Decarbonylase: a New Reaction of Di-iron Enzymes.” Angew. Chem. Int. Ed., 2011, 50, 7148-7152. (‡ co-first author)
2. Das, D.; Roy, G.; Mugesh, G.* “Anti-thyroid Drug Carbimazole and its Analogues: Synthesis and Inhibition of Peroxidase-Catalyzed Iodination of L-Tyrosine” J. Med. Chem., 2008, 51, 7313 – 7317.
1. Roy, G.; Das, D.; Mugesh, G.* “Bioinorganic Chemistry Aspects of the Inhibition of ThyroidHormone Biosynthesis by Anti-hyperthyroid Drugs.” Inorg. Chim. Acta, 2007, 360, 303 - 316. [Thisarticle has been cited in the Science Direct - TOP 25 Hottest Articles]
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