Earlier projects

Selected projects

* indicates undergraduate author; ** indicates graduate author

Teaching and learning projects

• Development of a course-based undergraduate research experience

  • Brame CJ, Pruitt WM, and Robinson LC. A molecular genetics laboratory course applying bioinformatics and cell biology in the context of original research. https://www.lifescied.org/doi/10.1187/cbe.08-07-0036

  • Chiang H*, Robinson LC, Brame CJ, and Messina TM. Molecular mechanics and dynamics characterization of an in silico mutated protein: A stand-alone lab module or support activity for in vivo and in vitro analyses of targeted protein. Biochemistry and Molecular Biology Education 41: 402-408, 2013. https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bmb.20737 

  • All students in a required genetics course participated in this project for five years, leading to bunches of presentations (and awards) at Centenary's Student Research Forum and several posters at the Experimental Biology meetings. 

• Projects developed by graduate students as part of Vanderbilt's BOLD (Blended and Online Learning Design) program 

  • Green NH**, McMahon DG, and Brame CJ. Using online active-learning techniques to convey time compensated sun compass orientation in the Eastern North American Monarch. Journal of Microbiology and Biology Education 17, 430-435, 2016.

  • Krimm H**, Schuele CM, Brame CJ. Viability of online learning for ensuring basic skills in speech-language pathology. Perspectives of the ASHA Special Interest Groups, doi:10.1044/persp2.SIG10.49, 2017.

  • Bowen RS**, Picard DR**, Verberne-Sutton S and Brame CJ. Incorporating student design in an HPLC lab activity promotes student metacognition and argumentation. Journal of Chemical Education, doi: 10.1021/acs.jchemed7b00258, 2018.

  • Teller L**, McDaniel J**, Schuele CM, and Brame CJ. The Blended and Online Learning Design Fellows Program: Developing Teacher-Researchers in Communication Sciences and Disorders. Teaching and Learning in Communication Sciences & Disorders, 6(2), Article 4. https://ir.library.illinoisstate.edu/tlcsd/vol6/iss2/4, 2022.

• A teaching tool for a Cancer Biology course

  • Ortega RA** and Brame CJ. The synthesis map is a multi-dimensional educational tool that provides insight into students’ mental models and promotes students’ synthetic knowledge generation. CBE- Life Sciences Education 14, 1-11, 2015.

Faculty development 

• Projects developed in collaboration with Junior Faculty Teaching Fellows. 

  • McClure N and Brame CJ. Asthma medications: A think-pair-share-square activity for nursing students. Nurse Educator, doi: 10.1097/NNE. 0000000000000725, 2020.

  • Hande K, Parish AL, Cook C, Glassford MA, Pitts CJ, Richmond A, Widmar SB, Brame CJ, and Kennedy B. Junior Faculty Teaching Fellowship: A model to support nursing education development. Nurse Educator DOI: 10.1097/NNE.0000000000000413, 2017.

• Projects developed to expand resources for faculty trying new teaching approaches (also see the teaching guides!)

  • Biel R* and Brame CJ. Traditional versus online biology courses: Connecting course design and student learning in an online setting. Journal of Microbiology and Biology Education 17, 417-422, 2016.

  • Brame CJ. Effective educational videos: Principles and guidelines for maximizing student learning from video content. CBE-Life Sciences Education 15, pii:es6, 2016.

  • Brame CJ and Biel R*. Test-enhanced learning: The potential for testing to promote greater learning in undergraduate science courses. CBE-Life Sciences Education 14, 1-12, 2015.

Histone code 

• Strahl BD, Briggs SD, Brame CJ, Caldwell JA, Koh SS, Ma H, Cook RG, Shabanowitz J, Hunt DF, Stallcup MR, and Allis CD. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr. Biol. 11: 996-1000, 2001. 

• Hsu J-Y, Sun Z-W, Li X, Reuben M, Tatchell K, Biship DK, Grushcow JM, Brame CJ, Caldwell JA, Hunt DF, Lin R, Smith MM, and Allis CD. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102: 279-291, 2000. 

Reactive oxidized lipids (isolevuglandins/isoketals)

• Davies SS, Amarnath V, Brame CJ, Boutaud O, and Roberts LJ, II. Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin g-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nature Protocols 2: 2079-2091, 2007.

• Brame CJ, Boutaud O, Davies S, Yang T, Oates JA, Salomon RG, Roden DM, Morrow JD, and Roberts LJ, II. Modification of proteins by isoketal-containing oxidized phospholipids. J. Biol. Chem. 279: 13447-51, 2004. 

• Brame CJ, Salomon RG, Morrow JD, and Roberts LJ, II. Identification of extremely reactive -ketoaldehydes as products of the isoprostane pathway. J. Biol. Chem. 274: 13139-13146, 1999. 

Other protein modification projects

• Webb DJ, Schroeder MJ, Brame CJ, Whitmore L, Shabanowitz J, Hunt DF,  and Horwitz AR. Paxillin phosphorylation sites mapped by mass spectrometry. J Cell Science 118: 4925-4929, 2005.

• Brame CJ, Moran MF, and McBroom-Cerajewski, LD. A mass spectrometry-based method for distinguishing between symmetrically and asymmetrically dimethylated arginine residues. Rapid Communications in Mass Spectrom. 18: 877-81, 2004.