• Chaperone-mediated autophagy regulates adipocyte differentiation

Susmita Kaushi, Yves R Juste, Kristen Lindenau, Shuxian Dong, Adrian Macho-Gonzales, Olaya Santiago-Fernandez, Mericka McCabe, Rajat Singh, Evripidis Gavathiotis, Ana Maria Cuervo. Sci. Adv. 8 (46) DOI: 10.1126/sciadv.abq2733 , 2022

• Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion

Gregory J Krause, Antonio Diaz, Maryam Jafari, Rabia R Khawaja, Esperanza Agullo-Pascual, Olaya Santiago-Fernández, Alicia L Richards, Kuei-Ho Chen, Phillip Dmitriev, Yan Sun, Stephanie K See, Kotb Abdelmohsen, Krystyna Mazan-Mamczarz, Nevan J Krogan, Myriam Gorospe, Danielle L Swaney, Simone Sidoli, Jose Javier Bravo-Cordero, Martin Kampmann, Ana Maria Cuervo. Aging Cell, e13713. doi: 10.1111/acel.13713, 2022

• The lysosomal proteome of senescent cells contributes to the senescence secretome

Miguel Rovira, Rebecca Sereda, David Pladevall-Morera, Valentina Ramponi, Ines Marin, Mate Maus, Julio Madrigal-Matute, Antonio Díaz, Fernando García, Javier Muñoz, Ana María Cuervo, Manuel Serrano. Aging Cell, e13707. doi: 10.1111/acel.13707, 2022

• Targeting NCoR-RAR interaction activates chaperone-mediated autophagy and protects against retinal degeneration

Gomez-Sintes R Xin Q, Diaz A, Garner TP, Cotto-Rios XM, Wu Y, McCabe M, Dong S, Reynolds CA, Patel B de la Villa P, Macian F, Boya P, Gavathiotis E, Cuervo AM. Nat. Comm. 13(1): 4220, doi: 10.1038/s41467-022-31869-1, 2022

• Protective role of chaperone-mediated autophagy against atherosclerosis.

Madrigal-Matute J, de Bruijn J, van Kuijk K, Riascos-Bernald DF, Diaz A, Tasset I, Martín-Segura A, Gijbel MJJ, Sander B, Kaushik S, Biessen EAL, Tiano S, Bourdenx M, Krause GJ, McCracken I, Baker A, Jin H, Sibinga N, Bravo-Cordero JJ, Macian F, Singh R, Rensen PCN, Berbée JFP, Pasterkamp G, Sluimerc JC, Cuervo AM. AM. Proc. Nat. Acad. Sci. Inaugural Paper, 2022 119(14):e2121133119. doi: 10.1073/pnas.2121133119, 2022

• Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

Kuo SH, Tasset I, Cheng MM, Diaz A, Pan MK, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P, Fan L, Kim D, Ko HS, Yacoubian T, Kanter E, Liu L, Tang G, Muñoz J, Sardi SP, Li A, Gan L, Cuervo AM, Sulzer D.. Sci Adv. 11;8(6):eabm6393. doi: 10.1126/sciadv.abm6393. 2022

• Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. .

Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu Vincent, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM. Nat. Cell Biol. 23(12):1255-1270 doi: 10.1038/s41556-021-00800-z. 2021

• Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.

Bourdenx M, Martin-Segura A, Scrivo A, Rodriguez-Navarro J, Kaushik S, Tasset I, Diaz A, Strom NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement C, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Cell, 2021. doi: 10.1016/j.cell.2021.03.048

• Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.

Caballero B, Bourdenx M, Luengo Martin E, Diaz A, Sohn PD, Chen X, Wang C, Wegman S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Karch CM, Goate A, Gesticki JE, Hyman BT, Gan L, Cuervo AM. Nat Comm, 2021. doi: 10.1038/s41467-021-22501

• Chaperone-mediated autophagy sustains haematopoietic stem-cell function.

Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D’Alessandro A, Will B, Cuervo AM. Nature, 2021. doi: 10.1038/s41586-020-03129-z

• Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo.

Dong S, Aguirre-Hernandez C, Scrivo A, Eliscovich C, Arias E, Bravo-Cordero JJ, Cuervo AM. Nature Comm, 2020. doi: 10.1038/s41467-019-14164-4

• Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.

Kirchner P, Bourdenx M, Madrigal-Matute J, Tiano S, Diaz A, Barholdy BA, Will B, Cuervo A. PLoS Biology, 2019. doi: 10.1371/journal.pbio.3000301

• Farnesyl Transferase Inhibition for the Treatment of Tauopathies.

Hernandez I, Luna G, Rauch JN, Reis S, Giroux M, Karch CM, Boctor D, Sibih Y, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman G, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate A, Fisher SK, Cuervo AM, Kosik KS. Sci Transl Med, 2019. doi: 10.1126/scitranslmed.aat3005

• Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.

Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS. Acta Neuropathol, 2018. doi: 10.1007/s00401-018-1925-9

• Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging.

Bejarano E, Murray J, Wang X, Pampliega, O, Yin D, Patel B, Yuste A, Wolkoff A, Cuervo AM. Aging Cell, 2018. doi: 10.1111/acel.12777

• Humanin is an endogenous activators of chaperone-mediated autophagy.

Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kuhn B, Cuervo AM, Muzumdar R. J Cell Biol, 2018. doi: 10.1083/jcb.201606095

• Interplay of pathogenic forms of human tau with different autophagic pathways.

Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Mandelkow E-, Mandelkow E, Cuervo AM. Aging Cell, 2017. doi: 10.2222/acel.12692

• Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.

Kaushik, S. Cuervo AM. Nat Cell Biol, 2015. doi: 10.1038/ncb3166

• Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage.

Park C, Shu Y, Cuervo AM. Nat Commun, 2015. doi: 10.1038/ncomms7823

• Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy.

Arias E., Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM. Mol Cell, 2015. doi: 10.1016/j.molcel.2015.05.030

• Huntingtin functions as a scaffold for selective macroautophagy.

Rui Y-N, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming EF, Bellen HJ, Cuervo AM, Zhang S. Nat Cell Biol, 2015. doi: 10.1038/ncb3101

• Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging.

Schneider S, Villarroya J, Diaz A, Patel B, Urbanska AM, Thi MM, Villarroya F, Santambrogio L, Cuervo AM. Aging Cell, 2015. doi: 10.1111/acel.12310

• Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation.

Schneider JL, Suh Y, Cuervo AM. Cell Metab, 2014. doi: 10.1016/j.cmet.2014.06.009

• Connexins modulate autophagosome biogenesis.

Bejarano E, Yuste A, Patel B, Stout RJ, Spary D, Cuervo AM. Nat Cell Biol, 2014. doi: 10.1038/ncb2934

• Functional interaction between autophagy and ciliogenesis.

Pampliega O, Orhon I, Patel B, Sridhar S, Diaz-Carretero A, Beau I, Codogno P, Satir B, Satir P, Cuervo AM. Nature, 2013. doi: 10.1038/nature12639

• Chemical modulation of chaperone-mediated autophagy by novel retinoic acid derivatives.

Anguiano J, Gaerner T, Daas B, Gavathiotis E, Cuervo AM. Nat Chem Biol, 2013. doi: 10.1038/nchembio.1230

• Interplay of LRRK2 with chaperone-mediated autophagy.

Orenstein SJ, Kuo SH, Tasset-Cuevas I, Arias E, Koga H, Fernandez-Carasa I, Cortes E, Honig LS, Dauer W, Consiglio A, Raya A, Sulzer, D, Cuervo AM. Nat Neurosci, 2013. doi: 10.1038/nn.3350