Publications

Selected Publications

Check the complete list of publications here

  • Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.

Bourdenx M, Martin-Segura A, Scrivo A, Rodriguez-Navarro J, Kaushik S, Tasset I, Diaz A, Strom NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement C, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Cell, 2021. doi: 10.1016/j.cell.2021.03.048

  • Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.

Caballero B, Bourdenx M, Luengo Martin E, Diaz A, Sohn PD, Chen X, Wang C, Wegman S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Karch CM, Goate A, Gesticki JE, Hyman BT, Gan L, Cuervo AM. Nat Comm, 2021. doi: 10.1038/s41467-021-22501

  • Chaperone-mediated autophagy sustains haematopoietic stem-cell function.

Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D’Alessandro A, Will B, Cuervo AM. Nature, 2021. doi: 10.1038/s41586-020-03129-z

  • Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo.

Dong S, Aguirre-Hernandez C, Scrivo A, Eliscovich C, Arias E, Bravo-Cordero JJ, Cuervo AM. Nature Comm, 2020. doi: 10.1038/s41467-019-14164-4

  • Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.

Kirchner P, Bourdenx M, Madrigal-Matute J, Tiano S, Diaz A, Barholdy BA, Will B, Cuervo A. PLoS Biology, 2019. doi: 10.1371/journal.pbio.3000301

  • Farnesyl Transferase Inhibition for the Treatment of Tauopathies.

Hernandez I, Luna G, Rauch JN, Reis S, Giroux M, Karch CM, Boctor D, Sibih Y, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman G, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate A, Fisher SK, Cuervo AM, Kosik KS. Sci Transl Med, 2019. doi: 10.1126/scitranslmed.aat3005

  • Pros and cons of chaperone-mediated autophagy in cancer.

Arias E, Cuervo AM. Trends Endocrinol Metab, 2019. doi: 10.1016/j.tem.2019.09.007

  • Analysis of chaperone-mediated autophagy.

Juste YR, Cuervo AM. Methods Mol Biol, 2019. doi: 10.1007/978-1-4939-8873-0_47

  • Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.

Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS. Acta Neuropathol, 2018. doi: 10.1007/s00401-018-1925-9

  • Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging.

Bejarano E, Murray J, Wang X, Pampliega, O, Yin D, Patel B, Yuste A, Wolkoff A, Cuervo AM. Aging Cell, 2018. doi: 10.1111/acel.12777

  • Humanin is an endogenous activators of chaperone-mediated autophagy.

Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kuhn B, Cuervo AM, Muzumdar R. J Cell Biol, 2018. doi: 10.1083/jcb.201606095

  • The coming of age of chaperone-mediated autophagy.

Kaushik K, Cuervo AM. Nat Rev Cell Mol Biol, 2018. doi: 10.1038/s41580-018-0001-6

  • Chaperone-mediated autophagy and endosomal microautophagy: joint by a chaperone. Tekirdag KA, Cuervo AM. J Biol Chem, 2018. doi: 10.1074/jbc.R117.818237

  • Selective autophagy as a potential therapeutic target for neurodegenerative disorders.

Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. Lancet Neurol, 2018. doi: 10.1016/S1474-4422(18)30238-2

  • Interplay of pathogenic forms of human tau with different autophagic pathways.

Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Mandelkow E-M, Mandelkow E, Cuervo AM. Aging Cell, 2017. doi: 10.2222/acel.12692

  • Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.

Kaushik, S. Cuervo AM. Nat Cell Biol, 2015. doi: 10.1038/ncb3166

  • Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage.

Park C, Shu Y, Cuervo AM. Nat Commun, 2015. doi: 10.1038/ncomms7823

  • Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy.

Arias E., Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM. Mol Cell, 2015. doi: 10.1016/j.molcel.2015.05.030

  • Huntingtin functions as a scaffold for selective macroautophagy.

Rui Y-N, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming EF, Bellen HJ, Cuervo AM, Zhang S. Nat Cell Biol, 2015. doi: 10.1038/ncb3101

  • Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging.

Schneider S, Villarroya J, Diaz A, Patel B, Urbanska AM, Thi MM, Villarroya F, Santambrogio L, Cuervo AM. Aging Cell, 2015. doi: 10.1111/acel.12310

  • Proteostasis and aging.

Kaushik S, Cuervo AM. Nat Med, 2015. doi: 10.1038/nm.4001

  • Methods to study chaperone-medidated autophagy.

Patel B, Cuervo AM. Methods, 2015. doi: 10.1016/j.ymeth.2015.01.003

  • Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation.

Schneider JL, Suh Y, Cuervo AM. Cell Metab, 2014. doi: 10.1016/j.cmet.2014.06.009

  • Connexins modulate autophagosome biogenesis.

Bejarano E, Yuste A, Patel B, Stout RJ, Spary D, Cuervo AM. Nat Cell Biol, 2014. doi: 10.1038/ncb2934

  • Functional interaction between autophagy and ciliogenesis.

Pampliega O, Orhon I, Patel B, Sridhar S, Diaz-Carretero A, Beau I, Codogno P, Satir B, Satir P, Cuervo AM. Nature, 2013. doi: 10.1038/nature12639

  • Chemical modulation of chaperone-mediated autophagy by novel retinoic acid derivatives.

Anguiano J, Gaerner T, Daas B, Gavathiotis E, Cuervo AM. Nat Chem Biol, 2013. doi: 10.1038/nchembio.1230

  • Interplay of LRRK2 with chaperone-mediated autophagy.

Orenstein SJ, Kuo SH, Tasset-Cuevas I, Arias E, Koga H, Fernandez-Carasa I, Cortes E, Honig LS, Dauer W, Consiglio A, Raya A, Sulzer, D, Cuervo AM. Nat Neurosci, 2013. doi: 10.1038/nn.3350

  • Methods to monitor chaperone-mediated autophagy.

Kaushik S, Cuervo AM. Methods. Enzymol, 2009. doi: 10.1016/S0076-6879(08)03619-7

  • Chaperone-mediated autophagy.

Kaushik S, Cuervo AM. Methods Mol Biol, 2008. doi: 10.1007/978-1-59745-157-4_15