Publications
Selected Publications
Check the complete list of publications here
Calorie restriction and calorie restriction mimetics activate chaperone-mediated autophagy.
Jafari, M, Marcho-Gonzalez, A., Diaz A, Lindenau K, Santiago-Fernandez O, Zang M, Massey A C., deCabo R, Kaushik S, Cuervo AM. Proc. Nat. Acad. Sci., 2024. DOI: 10.1073/pnas.2317945121
Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy
Krause GJ, Kirchner P, Stiller B, Morozova K, Diaz A, Chen KH, Krogan NJ, Agullo-Pascual E, Clement CC, Lindenau K, Swaney DL, Dilipkumar S, Bravo-Cordero JJ, Santambrogio L, Cuervo AM. . Cell Rep. , 2023.DOI: 10.1016/j.celrep.2023.113529
Chaperone-mediated autophagy regulates adipocyte differentiation
Kaushik S, Juste YR, Lindenau K, Dong S, Macho-Gonzales A, Santiago-Fernandez O, McCabe M, Singh R, Gavathiotis E, Sci. Adv., 2022. doi: DOI: 10.1126/sciadv.abq2733
Targeting NCoR-RAR interaction activates chaperone-mediated autophagy and protects against retinal degeneration.
Gomez-Sintes R Xin Q, Diaz A, Garner TP, Cotto-Rios XM, Wu Y, McCabe M, Dong S, Reynolds CA, Patel B de la Villa P, Macian F, Boya P, Gavathiotis E, Cuervo AM. . Nat. Comm., 2022.DOI: 10.1038/s41467-022-31869-1
Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion.
Krause GJ, Diaz A, Jafari M, Khawaja RR, Agullo-Pascual E, Santiago-Fernández O, Richards AL, Chen KH, Dmitriev P, Sun Y, See SK, Abdelmohsen K, Mazan-Mamczarz K, Krogan NJ, Gorospe M, Swaney DL, Sidoli S, Bravo-Cordero JJ, Kampmann M, Cuervo AM . Aging Cell., 2021.DOI: 10.1111/acel.13713
Protective role of chaperone-mediated autophagy against atherosclerosis.
Madrigal-Matute J, de Bruijn J, van Kuijk K, Riascos-Bernald DF, Diaz A, Tasset I, Martín-Segura A, Gijbel MJJ, Sander B, Kaushik S, Biessen EAL, Tiano S, Bourdenx M, Krause GJ, McCracken I, Baker A, Jin H, Sibinga N, Bravo-Cordero JJ, Macian F, Singh R, Rensen PCN, Berbée JFP, Pasterkamp G, Sluimerc JC, Cuervo AM. . Proc. Nat. Acad. Sci.., 2022.DOI: 10.1073/pnas.2121133119
Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
Kuo SH, Tasset I, Cheng MM, Diaz A, Pan MK, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P, Fan L, Kim D, Ko HS, Yacoubian T, Kanter E, Liu L, Tang G, Muñoz J, Sardi SP, Li A, Gan L, Cuervo AM, Sulzer D. Sci..Adv. , 2022. DOI: 10.1126/sciadv.abm6393
Reciprocal regulation of chaperone-mediated autophagy and the circadian clock
Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu Vincent, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM. . Nat. Cell Biol. , 2021.DOI: 10.1038/s41556-021-00800-z
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Bourdenx M, Martin-Segura A, Scrivo A, Rodriguez-Navarro J, Kaushik S, Tasset I, Diaz A, Strom NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement C, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Cell, 2021. doi: 10.1016/j.cell.2021.03.048
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
Caballero B, Bourdenx M, Luengo Martin E, Diaz A, Sohn PD, Chen X, Wang C, Wegman S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Karch CM, Goate A, Gesticki JE, Hyman BT, Gan L, Cuervo AM. Nat Comm, 2021. doi: 10.1038/s41467-021-22501
Chaperone-mediated autophagy sustains haematopoietic stem-cell function.
Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D’Alessandro A, Will B, Cuervo AM. Nature, 2021. doi: 10.1038/s41586-020-03129-z
Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo.
Dong S, Aguirre-Hernandez C, Scrivo A, Eliscovich C, Arias E, Bravo-Cordero JJ, Cuervo AM. Nature Comm, 2020. doi: 10.1038/s41467-019-14164-4
Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.
Kirchner P, Bourdenx M, Madrigal-Matute J, Tiano S, Diaz A, Barholdy BA, Will B, Cuervo A. PLoS Biology, 2019. doi: 10.1371/journal.pbio.3000301
Farnesyl Transferase Inhibition for the Treatment of Tauopathies.
Hernandez I, Luna G, Rauch JN, Reis S, Giroux M, Karch CM, Boctor D, Sibih Y, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman G, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate A, Fisher SK, Cuervo AM, Kosik KS. Sci Transl Med, 2019. doi: 10.1126/scitranslmed.aat3005
Pros and cons of chaperone-mediated autophagy in cancer.
Arias E, Cuervo AM. Trends Endocrinol Metab, 2019. doi: 10.1016/j.tem.2019.09.007
Analysis of chaperone-mediated autophagy.
Juste YR, Cuervo AM. Methods Mol Biol, 2019. doi: 10.1007/978-1-4939-8873-0_47
Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.
Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS. Acta Neuropathol, 2018. doi: 10.1007/s00401-018-1925-9
Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging.
Bejarano E, Murray J, Wang X, Pampliega, O, Yin D, Patel B, Yuste A, Wolkoff A, Cuervo AM. Aging Cell, 2018. doi: 10.1111/acel.12777
Humanin is an endogenous activators of chaperone-mediated autophagy.
Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kuhn B, Cuervo AM, Muzumdar R. J Cell Biol, 2018. doi: 10.1083/jcb.201606095
The coming of age of chaperone-mediated autophagy.
Kaushik K, Cuervo AM. Nat Rev Cell Mol Biol, 2018. doi: 10.1038/s41580-018-0001-6
Chaperone-mediated autophagy and endosomal microautophagy: joint by a chaperone. Tekirdag KA, Cuervo AM. J Biol Chem, 2018. doi: 10.1074/jbc.R117.818237
Selective autophagy as a potential therapeutic target for neurodegenerative disorders.
Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. Lancet Neurol, 2018. doi: 10.1016/S1474-4422(18)30238-2
Interplay of pathogenic forms of human tau with different autophagic pathways.
Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Mandelkow E-M, Mandelkow E, Cuervo AM. Aging Cell, 2017. doi: 10.2222/acel.12692
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.
Kaushik, S. Cuervo AM. Nat Cell Biol, 2015. doi: 10.1038/ncb3166
Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage.
Park C, Shu Y, Cuervo AM. Nat Commun, 2015. doi: 10.1038/ncomms7823
Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy.
Arias E., Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM. Mol Cell, 2015. doi: 10.1016/j.molcel.2015.05.030
Huntingtin functions as a scaffold for selective macroautophagy.
Rui Y-N, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming EF, Bellen HJ, Cuervo AM, Zhang S. Nat Cell Biol, 2015. doi: 10.1038/ncb3101
Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging.
Schneider S, Villarroya J, Diaz A, Patel B, Urbanska AM, Thi MM, Villarroya F, Santambrogio L, Cuervo AM. Aging Cell, 2015. doi: 10.1111/acel.12310
Proteostasis and aging.
Kaushik S, Cuervo AM. Nat Med, 2015. doi: 10.1038/nm.4001
Methods to study chaperone-medidated autophagy.
Patel B, Cuervo AM. Methods, 2015. doi: 10.1016/j.ymeth.2015.01.003
Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation.
Schneider JL, Suh Y, Cuervo AM. Cell Metab, 2014. doi: 10.1016/j.cmet.2014.06.009
Connexins modulate autophagosome biogenesis.
Bejarano E, Yuste A, Patel B, Stout RJ, Spary D, Cuervo AM. Nat Cell Biol, 2014. doi: 10.1038/ncb2934
Functional interaction between autophagy and ciliogenesis.
Pampliega O, Orhon I, Patel B, Sridhar S, Diaz-Carretero A, Beau I, Codogno P, Satir B, Satir P, Cuervo AM. Nature, 2013. doi: 10.1038/nature12639
Chemical modulation of chaperone-mediated autophagy by novel retinoic acid derivatives.
Anguiano J, Gaerner T, Daas B, Gavathiotis E, Cuervo AM. Nat Chem Biol, 2013. doi: 10.1038/nchembio.1230
Interplay of LRRK2 with chaperone-mediated autophagy.
Orenstein SJ, Kuo SH, Tasset-Cuevas I, Arias E, Koga H, Fernandez-Carasa I, Cortes E, Honig LS, Dauer W, Consiglio A, Raya A, Sulzer, D, Cuervo AM. Nat Neurosci, 2013. doi: 10.1038/nn.3350
Methods to monitor chaperone-mediated autophagy.
Kaushik S, Cuervo AM. Methods. Enzymol, 2009. doi: 10.1016/S0076-6879(08)03619-7
Chaperone-mediated autophagy.
Kaushik S, Cuervo AM. Methods Mol Biol, 2008. doi: 10.1007/978-1-59745-157-4_15