Publications

2025 Publications

1. Carr D.F,UG (Nursing '23), Gunari S.F,UG (Speech Pathology and Audiology '25), Gorostiza G.PB (PHAP '24), Mercado M.UG (Biological Sciences '27), Pavana L.UG (Biological Sciences '24), Duong L., Gomez K., Salinas S., Garcia G., Tsang A., Morisseau C., Hammock B.D., Pecic S.C, Kandasamy R.C (2025). Synthesis and evaluation of isoquinolinyl and pyridinyl-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase to alleviate orofacial hyperalgesia in the rat. Biochemistry and Biophysics Reports, 42, 102009. PMID: 40275962.

2. Yuan C., Tsang A., Berumen M., Rodriguez A., Yun F., Mesic A., Olivares A., Dubon L., Nguyen A., Pavana L.UG (Biological Sciences '24), Mercado M.UG (Biological Sciences '27), Gorostiza G.PB (PHAP '24), Morisseau C., Hammock B.D., Kandasamy R.C, Pecic S.C (2025). Structure-activity relationship studies and pharmacological evaluation of 4-phenylthiazoles as dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorganic & Medicinal Chemistry. 121, 118112. PMID: 39983408.

2024 Publications

3. Carr D.F,UG (Nursing '23), Chin C. F,UG (Psychology '22), Chacon T. UG (Health Sciences '24), Khoja Herawi M. UG (Biological Sciences '24), Gonzalez M., West R., Morisseau C., Hammock B.D., Pecic S.C, Kandasamy R.C (2024). 4-phenyl-thiazole-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase do not alleviate orofacial inflammatory pain in female rats. BBA Advances, 6:100119. PMID: 39246819.

4. Angelia J., Duong L., Yun F., Mesic A., Yuan C.UG (Biological Sciences '23), Carr D.UG (Nursing '23), Gunari S.UG (Speech Pathology and Audiology '25), Hudson P.K., Morisseau C., Hammock B.D., Kandasamy R.C, Pecic SC. (2024). Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: synthetic studies and pharmacological evaluations. Heliyon, 10 (11), e32262. PMID: 38912512.

2023 Publications

5. Morgan M.M., Hilgendorf T.N.UG, Kandasamy R. (2023). Continuous fentanyl administration and spontaneous withdrawal decreases home cage wheel running in rats with and without hindpaw inflammation. Physiology and Behavior, 272. PMID: 37820887.

6. Olson K.M., Devereaux A.L., Chatterjee P., Saldaña-Shumaker S.L., Shafer A., Plotkin A., Kandasamy R., MacKerell Jr. A.D., Traynor J.R., Cunningham C.W. (2023). Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy. Frontiers in Pharmacology, 14. PMID: 37469877.

7. Angelia J., Weng X., Solomatov A., Chin C.UG (Psychology '22), Fernandez A.PB (PHAP '22), Hudson P.K., Morisseau C., Hammock B.D., Kandasamy R.C, Pecic SC. (2023). Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior. Prostaglandins and Other Lipid Mediators, 164. PMID: 36529320

2021 Publications

8. Wilt S., Kodani S., Valencia L., Hudson P.K., Sanchez S.UG (Biological Sciences '23), Quintana T.UG (Psychology, Biological Sciences '22), Morisseau C., Hammock B.D., Kandasamy R.C, Pecic SC. (2021). Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorganic & Medicinal Chemistry, 51, 116507. PMID: 34794001

9. Rodriguez C.E.B.F,UG (Psychology '20), Ouyang L.F,UG (Biological Sciences '23), Kandasamy R.C (2021). Antinociceptive effects of minor cannabinoids, terpenes, and flavonoids in Cannabis. Behavioural Pharmacology, in press. PMID: 33709984

10. Kandasamy R.F, Hillhouse T.M.F, Livingston K.E., Kochan K.E., Meurice C., Eans. S.O., Li M., White A.D., Roques B.P., McLaughlin J.P., Ingram S.L., Burford N.T., Alt A., Traynor J.R. (2021). Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side-effects. Proceedings of the National Academy of Sciences, 118(16), e2000017118. PMID: 33846420

11. Kandasamy R.C and Morgan M.M. (2021). “Reinventing the wheel” to advance the development of pain therapeutics. Behavioural Pharmacology, 32(2&3), 142-152. PMID: 33079736

2020 Publications

12. Senese N.B., Kandasamy R., Kochan K.E., Traynor J.R. (2020). Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management. Frontiers in Molecular Neuroscience, 13:5. PMID: 32028168

2018 Publications

13. Stanczyk M.A. and Kandasamy R. (2018). Biased agonism: The quest for the analgesic holy grail. PAIN Reports, 3(3), e650. PMID: 29922742

14. Kandasamy R., Dawson C.T.UG, Hilgendorf T.N.UG, Morgan M.M. (2018). Medication overuse headache following repeated morphine, but not ∆9-tetrahydrocannabinol administration in the female rat. Behavioural Pharmacology, 29(5), 469-472. PMID: 29462111

15. Kandasamy R., Dawson C.T.UG, Craft, R.M., Morgan M.M. (2018). Anti-migraine effect of ∆9-tetrahydrocannabinol in the female rat. European Journal of Pharmacology, 818, 271-277. PMID: 29111112

2017 Publications

16. Kandasamy R., Lee A.T.UG, Morgan M.M. (2017). Depression of home cage wheel running is an objective measure of spontaneous morphine withdrawal in rats with and without persistent pain. Pharmacology, Biochemistry and Behavior, 156, 10-15. PMID: 28366799

17. Kandasamy R., Lee A.T.UG, Morgan M.M. (2017). Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats. The Journal of Headache and Pain, 18(1):5, 1-8. PMID: 28091820

18. Kandasamy R., Calsbeek J.J.UG, Morgan M.M. (2017). Analysis of inflammation-induced depression of home cage wheel running in rats reveals the difference between opioid antinociception and restoration of function. Behavioural Brain Research, 317, 502-507. PMID: 27746208

2016 Publications

19. Kandasamy R., Calsbeek J.J.UG, Morgan M.M. (2016). Home cage wheel running is an objective and clinically relevant method to assess inflammatory pain in male and female rats. Journal of Neuroscience Methods, 263, 115-122.PMID: 26891874

2015 Publications

20. Kandasamy R. and Price T.J. (2015). The pharmacology of nociceptor priming. In Pain Control (Handbook of Experimental Pharmacology) 15-37. Ed. H-G Schaible, Springer Berlin Heidelberg. PMID: 25846612

2013 Publications

21. Craft R.M., Kandasamy R., Davis S.M. (2013). Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat. PAIN, 154(9), 1709-1717. PMID: 23707295

UG = undergraduate co-author

PB = postbaccalaureate co-author

F = co-first author

C = corresponding author