Our research is centered on elucidating the three-dimensional architectures of macromolecular protein and ribosomal complexes to uncover their functional mechanisms at the atomic level. We specialize in cryo-electron microscopy (cryo-EM) and single-particle reconstruction, which allows us to determine high-resolution structures of such biomolecular assemblies in near-native states. Additionally, we also employ cryo-tomography and sub-tomogram averaging to peek into the landscape of macromolecules in the cellular context.

To achieve this, our laboratory has access to multiple state-of-the-art 300-kV cryo-electron microscopes with direct electron detection capabilities at several cryo-EM facilities throughout India, enabling us in high-resolution structural data collection. Additionally, we are equipped with high-performance GPU-workstations that are routinely used in cryo-EM data processing, allowing for high-resolution 3D reconstruction, refinement, and analysis of macromolecular structures. Currently, we are excited about how to combat antimicrobial resistance by designing better drugs for a safer tomorrow.