Our vision
Our vision
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The main goal of Coppola lab is comprehending the conserved regulatory mechanisms underlying the formation of different heart compartments in chordates. Applying a unique combination of evolutionary genomics, developmental biology and genetics on zebrafish and tunicates, our lab is poised at the forefront of cardiac evolutionary developmental biology (cardiac evo-devo). Seeking to uncover the conserved regulatory networks in vertebartes' heart development, we hope to pave the way to develop novel cures and therapies for cardiac pathologies.
Evolutionary Genomics
Evolutionary Genomics
We have 10 years of experience in evolutionary genomics studying multiple gene families (Rabs, Klhl, Nr2f). Currently, we are analyzing the evolution of ubiquitination gene families and their potential involvement in heart development.
Cardiac developmental Biology
Cardiac developmental Biology
We are interested in understanding novel conserved mechanisms regulating heart development in zebrafish. Specifically, we are targeting multiple members of fox superfamily.
Cardiac reg-evo-devo
Cardiac reg-evo-devo
We aim to understand the conserved gene regulatory networks (GRNs) dictating the formation and the evolution of distinct cardiac compartments in chordates, using zebrafish and tunicates. In particular, we are targeting new conserved enhancers within Nr2f genome environment.
Disease modeling
Disease modeling
To expand the activities of our lab, we are interested in analyzing pathways potentially involved in cardiac diseases and congenital heart defects (CHDs) using zebrafish.
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