Huang D, Liu X, Gao X, Choi CK, Giglio G, Farah L, Leung TF, Wong KC, Kan LL, Chong JW, Meng QJ, Liao J, Cheung PF, Wong CK. Meteorin-like protein/METRNL/Interleukin-41 ameliorates atopic dermatitis-like inflammation. Allergy. 2024. doi: 10.1111/all.16150.

Gao X, Chan PK, Wong KC, Ng RW, Yeung AC, Lui GC, Ling L, Hui DS, Huang D, Wong CK. Characterization of METRNβ as a novel biomarker of Coronavirus disease 2019 severity and prognosis. Front Immunol. 2023;14:1111920. doi: 10.3389/fimmu.2023.1111920.

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Gao X, Leung TF, Wong GW, Ko WH, Cai M, He EJ, Chu IM, Tsang MS, Chan BC, Ling J, Fan X, Lu L, Lam CW, Wong CK. Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma. Cell Mol Immunol. 2022;19:245-259. doi: 10.1038/s41423-021-00803-8.

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Gao X, Chan PKS, Lui GCY, Hui DSC, Chu IM, Sun X, Tsang MS, Chan BCL, Lam CW, Wong CK. Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections. Cell Death Dis. 2021;12:53. doi: 10.1038/s41419-020-03283-2.

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Hou T, Tsang MS, Chu IM, Kan LL, Hon KL, Leung TF, Lam CW, Wong CK. Skewed inflammation is associated with aberrant interleukin-37 signaling pathway in atopic dermatitis. Allergy. 2021;76:2102-2114. doi: 10.1111/all.14769.

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Cai Z, Zhang S, Wu P, Ren Q, Wei P, Hong M, Feng Y, Wong CK, Tang H, Zeng H. A novel potential target of IL-35-regulated JAK/STAT signaling pathway in lupus nephritis. Clin Transl Med. 2021 Feb;11:e309. doi: 10.1002/ctm2.309.

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Wu XX, Yue GGL, Dong JR, Lam CWK, Wong CK (Correspondence Author), Qiu MH, Lau CBS. Actein inhibits tumor growth and metastasis in HER2-positive breast tumor bearing mice via suppressing AKT/mTOR and Ras/Raf/MAPK signaling pathways. Frontiers in Oncology. 2020; 10: 854. DOI: 10.3389/fonc.2020.00854

Hou T, Sun X, Zhu J, Hon KL, Jiang P, Chu IMT, Tsang MSM, Lam CWK, Zeng H, Wong CK (Correspondence Author). IL-37 ameliorating allergic inflammation in atopic dermatitis through regulating microbiota and AMPK-mTOR signaling pathway-modulated autophagy mechanism. Frontiers in Immunology 2020; 11: 752. doi: 10.3389/fimmu.2020.00752.

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Sun X, Hou T, Cheung EC, Iu TN, Tam VW, Chu IM, Tsang MS, Chan PK, Lam CW, Wong CK (Correspondence Author). Anti-inflammatory Mechanisms of the Novel Cytokine Interleukin-38 in Allergic Asthma. Cellular & Molecular Immunology 2020; 17:631–646; DOI: 10.1038/s41423-019-0300-7.

Wu XX, Yue GG, Dong JR, Lam CW, Wong CK (correspondence Author), Qiu MH, Lau CB. Actein Inhibits the Proliferation and Adhesion of Human Breast Cancer Cells and Suppresses Migration in vivo. Frontiers in Pharmacology 2018; 9: 1466. doi: 10.3389/fphar.2018.01466.

Zhu J, Dong J, Ji L, Jiang P, Leung TF, Liu D, Ng LG, Tsang MSM, Jiao D, Lam CWK, Wong CK (Correspondence Author). Anti-allergic inflammatory activity of interleukin-37 is mediated by novel signaling cascades in human eosinophils. Frontiers in Immunology 2018; 9:1445. doi: 10.3389/fimmu.2018.01445.

Jiao D, Wong CK (equal 1st author, correspondence author), Qiu HN, Dong J, Cai Z, Chu M, Hon  KL, Tsang MSM, Lam CWK. NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation. Cell Mol Immunol 2016; 13: 535-550. 

Dong J, Wong CK (equal 1st author, correspondence author), Cai Z, Jiao D, Chu M and Lam CWK. Amelioration of allergic airway inflammation in mice by regulatory IL-35 through dampening inflammatory dendritic cells. Allergy 2015; 70: 921–932.

Li P, Hon SS, Tsang MS, Kan LL, Lai AY, Chan BC, Leung PC, Wong CK. Integrating 16S rRNA Sequencing, Microflora Metabolism, and Network Pharmacology to Investigate the Mechanism of SBL in Alleviating HDM-Induced Allergic Rhinitis. IJMS. 2024.

Kan LL, Chan BC, Yue GG, Li P, Hon SS, Huang D, Tsang MS, Lau CB, Leung PC, Wong CK. Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice. Chin J Integr Med. 2024;30:311-321. doi: 10.1007/s11655-023-3745-6.

Ling J, Chan BC, Tsang MS, Gao X, Leung PC, Lam CW, Hu JM, Wong CK. Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine. Front Med (Lausanne). 2022;8:815075. doi: 10.3389/fmed.2021.815075.

Li P, Tsang MS, Kan LL, Hou T, Hon SS, Chan BC, Chu IM, Lam CW, Leung PC, Wong CK. The Immuno-Modulatory Activities of Pentaherbs Formula on Ovalbumin-Induced Allergic Rhinitis Mice via the Activation of Th1 and Treg Cells and Inhibition of Th2 and Th17 Cells. Molecules. 2021;27:239. doi: 10.3390/molecules27010239.

Wu XX, Siu WS, Wat CL, Chan CL, Koon CM, Li X, Cheng W, Ma H, Tsang MSM, Lam CW, Leung PC, Lau CBS, Wong CK. Effects of topical application of a tri-herb formula on inflammatory dry-skin condition in mice with oxazolone-induced atopic dermatitis. Phytomedicine. 2021;91:153691. doi: 10.1016/j.phymed.2021.153691.

Kan LL, Liu D, Chan BC, Tsang MS, Hou T, Leung PC, Lam CW, Wong CK. The flavonoids of Sophora flavescens exerts anti-inflammatory activity via promoting autophagy of Bacillus Calmette-Guérin-stimulated macrophages. J Leukoc Biol. 2020;108:1615-1629. doi: 10.1002/JLB.3MA0720-682RR.

Tsang MS, Cheng SW, Zhu J, Atli K, Chan BC, Liu D, Chan HY, Sun X, Chu IM, Hon KL, Lam CW, Shaw PC, Leung PC, Wong CK. Anti-Inflammatory Activities of Pentaherbs formula and Its Influence on Gut Microbiota in Allergic Asthma. Molecules. 2018;23:2776. doi: 10.3390/molecules23112776.

Liu D, Chan BC, Cheng L, Tsang MS, Zhu J, Wong CW, Jiao D, Chan HY, Leung PC, Lam CW, Wong CK. Sophora flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages. Sci Rep. 2018;8:3903. doi: 10.1038/s41598-018-22286-w.