The goal of this project is to identify, acquire, and analyze novel quantitative metrics of human perception, cognition, behavior, performance which are otherwise qualitative in nature. This project involves development of audio-visual stimuli and multimodal imaging platform using computer vision, virtual reality, and state-of-the-art animation tool, conducting of IRB-approved human studies to collect multimodal and spatio-temporal data about human responses to stimuli, and quantitative differential analysis (both Statistical and AI) to answer human-centric research questions. Data-driven approach to understand human responses and behavior to target stimuli has tremendous value in the investigation for novel biomarker and therapeutic tools for behavioral disorders such as Autism Spectrum Disorders. This project is a collaborative effort of researchers from four institutions including Tennessee State University.