COVID-19 antibody responses in children and elderly

Age-dependent antibody signatures are observed in COVID-19 patients. SARS-CoV-2-specific IgA and IgG features were associated with increasing age, especially to both Spike 2 (S2) and NP, which could be a result of cross-reactivity driven by prior exposure to human Coronavirus antigens. 

Image extracted from Figure 6, Selva, K.J., et al., Systems serology detects functionally distinct coronavirus antibody features in children and elderly. Nat Commun, 2021. 12(1): p. 2037