Our research combines the design, synthesis and characterization of small organic fluorescent molecules followed by investigation of the light induced behavior and evaluation of their stimuli responsive functions. Our current research focuses on two aspects: Materials exhibiting aggregation induced emission and 2. Donor-Acceptor fluorescent molecules for providing real time visualization of the cellular world.
1. Antibacterial Fluorophores and Microbial Imaging
Antimicrobial resistance (AMR) and biofilm formation represent major challenges in the effective treatment of bacterial infections, often leading to reduced drug efficacy and persistent infections. Addressing these challenges requires tools that not only inhibit bacterial growth but also enable direct visualization of bacterial behavior and response to treatment. Our research focuses on the development of small-molecule fluorescent probes for bacterial imaging and antibacterial mechanism studies, enabling rapid staining of Gram-positive and Gram-negative bacteria as well as visualization of biofilm states. By integrating photophysical characterization with microbiological assays, this work investigates bacterial uptake, membrane interactions, biofilm inhibition, and resistance development, providing molecular-level insight into probe–bacteria interactions relevant to diagnostic and antimicrobial research.
2. Aggregation Induced Emission (AIE)
Aggregation-induced emission is an abnormal phenomenon that is observed with certain organic luminophores where in they show higher photoemission efficiencies in solid state than in the solution state. Our current focus is on the synthesis of several derivatives of cyanostilbenes and investigation of their light-induced behavior. Suitable substitution also yields excellent aggregation induced emission properties with the formation of self-assemblies and organogels.
3. Biomolecular Imaging and Sensing Applications
Our group is interested is preparing chromophores emitting in the red and NIR regions for investigation of biomolecular interactions, imaging of subcellular organelles such as mitochondria and plasma membrane or sensing of biomolecular analytes.
4. Cellular and Tissue Imaging for Biomedical Applications
Our group is interested is preparing chromophores emitting in the red and NIR regions for imaging cellular organelle, their stress, imbalances and advancement at tissues level as well.