Welcome to MIND Lab!
Molecular Intelligence in Neuroimmunology and Disease
Department of Chemistry, Purdue University
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đŸ’¡Chemistry | Artificial Intelligence | Neuroimmunology
đŸ’¡Chemistry | Artificial Intelligence | Neuroimmunology
We are a vibrant group of chemists, immunologists, neuroscientists and AI scientists focused on identifying the role of metabolism (lipids, metabolites) on the function and dysfunction of immune and glial cells for chronic neuroinflammatory diseases!Â
We are a vibrant group of chemists, immunologists, neuroscientists and AI scientists focused on identifying the role of metabolism (lipids, metabolites) on the function and dysfunction of immune and glial cells for chronic neuroinflammatory diseases!Â
MIND (Molecular Intelligence in Neuroimmunology and Disease) laboratory combines neuroscience, chemistry, immunology and artificial intelligence (AI) with basic science guided translational focus to improve human health in neurological diseases, such as neurodegeneration, aging and injury, guided by the overarching question: How do lipids and lipid accumulation modulate glial and immune cell function and modulate immune tolerance in the brain during neuroinflammation? Â We are an interdisciplinary team focused on uncovering and targeting lipid and metabolic mechanisms that drive glial and immune cell dysfunction in neuroinflammation. Our work has revealed how lipid accumulation pathways in glial cells contribute to neurodegeneration and aging, with a broader emphasis on lipid-based neuroimmune mechanisms and antigen presentation. To advance this mission, we develop cutting-edge single-cell lipidomics technologies, design targeted neuro-immune therapies, and integrate neuro-inspired artificial intelligence automation platforms to accelerate experimental validation and drug discovery in neuroimmunology. The MIND lab is at the forefront of developing technology and doing functional studies in human iPSC and mouse models along with generously donated postmortem human brain tissue samples to identify targets to modulate immune tolerance in the brain.
MIND (Molecular Intelligence in Neuroimmunology and Disease) laboratory combines neuroscience, chemistry, immunology and artificial intelligence (AI) with basic science guided translational focus to improve human health in neurological diseases, such as neurodegeneration, aging and injury, guided by the overarching question: How do lipids and lipid accumulation modulate glial and immune cell function and modulate immune tolerance in the brain during neuroinflammation? Â We are an interdisciplinary team focused on uncovering and targeting lipid and metabolic mechanisms that drive glial and immune cell dysfunction in neuroinflammation. Our work has revealed how lipid accumulation pathways in glial cells contribute to neurodegeneration and aging, with a broader emphasis on lipid-based neuroimmune mechanisms and antigen presentation. To advance this mission, we develop cutting-edge single-cell lipidomics technologies, design targeted neuro-immune therapies, and integrate neuro-inspired artificial intelligence automation platforms to accelerate experimental validation and drug discovery in neuroimmunology. The MIND lab is at the forefront of developing technology and doing functional studies in human iPSC and mouse models along with generously donated postmortem human brain tissue samples to identify targets to modulate immune tolerance in the brain.
How do immune and glial cells become dysfunctional and modulate immune tolerance in the brain during disease?
How do lipids mediate glial and immune cell function, lead to dysfunction and modulate immune tolerance in neurodegeneration?
How can we target lipid accumulation in specific immune and glial cells for neuroimmune therapy?
Cell Targeting Chimeras (CellTAC): Cell-specific targeting of small-molecule drugs to specific glial and immune cells to modulate neuroimmune function.
Neurosymbolic Foundation Models of Drug Discovery & Development by incorporating Artificial Intelligence and Agentic Framework for Contextual Engineering
Neurosymbolic Foundation Models of Drug Discovery & Development by incorporating Artificial Intelligence and Agentic Framework for Contextual Engineering
Develop High-Throughput Mass Spectrometry Instrumentation and integrate with Artificial Intelligence Frameworks for Deep- and Single-Cell Lipidomics for Neuroimmunology
Develop High-Throughput Mass Spectrometry Instrumentation and integrate with Artificial Intelligence Frameworks for Deep- and Single-Cell Lipidomics for Neuroimmunology
Logo credits: Smith Lab at the University of Notre Dame
Our commitment to diversity, equity, and inclusion.Â
Our commitment to diversity, equity, and inclusion.Â
We pledge to actively work towards fostering a diverse and inclusive environment for all our members irrespective of their race, color, age, religion, sexual orientation, gender, disability, or national origin. We celebrate and use our differences to better our science. Our goal is to provide our members a safe space to thrive and pursue their scientific curiosities to their fullest potential.
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