What we are interested in is

Research Interest

Effective tissue regeneration coupling with wound repair is critical for the restoration of tissue integrity and function, which rely on regenerative capacity of stem cells following tissue injury. My Research interests have been focused on addressing how stem cells sense the surroundings and integrate the environmental stimuli to subsequently determine their fate/plasticity and function in response to injury. Understanding how stem cells respond to varying physiological and pathological situation requires a close inspection of their local microenvironments (Niche). Tissue injury instigates an inflammatory response by modulating immune system in the wound sites. Beyond the ability to clear pathogens, inflammation subsequently involves tissue repair. My research aims to understand how inflammation and immune system coordinate the lung regeneration by regulating stem cell plasticity and remodelling their niches during injury repair. Further, our lab will elucidate how altered regeneration programme is associated with the initiation and progression of chronic lung diseases such as lung cancer and pulmonary fibrosis.

To answer these questions, our lab will make a use of a combination of in vivo mouse models with lineage-tracing techniques, ex vivo 3D organoid culture system of human and mouse lungs with genetic manipulation techniques, and bioinformatic approaches of multi-omic analysis at the single cell level (single cell RNA/ATAC-sequencing analysis).